A5043625183- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Uterine Myomas and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Endometriosis Research and Treatment
- TGF-β signaling in diseases
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Economic and Financial Impacts of Cancer
- Cervical Cancer and HPV Research
- Cancer Research and Treatments
- Sarcoma Diagnosis and Treatment
- Kruppel-like factors research
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Ethics in Clinical Research
- Lung Cancer Treatments and Mutations
University of Alabama
2017-2025
University of Alabama at Birmingham
2016-2025
Sana Kliniken Duisburg
2025
O'Neal Comprehensive Cancer Center
2020-2024
Cancer Institute (WIA)
2023-2024
Cleveland Clinic
2023-2024
University Hospitals Seidman Cancer Center
2023-2024
Sylvester Comprehensive Cancer Center
2023
University of Colorado Denver
2023
University of Colorado Cancer Center
2023
Adenocarcinoma of the endometrium (also known as endometrial cancer, or more broadly uterine cancer carcinoma corpus) is most common malignancy female genital tract in United States. It estimated that 65,950 new cases will have occurred 2022, with 12,550 deaths resulting from disease. Endometrial includes pure endometrioid and carcinomas high-risk histology (including serous carcinoma, clear cell carcinosarcoma [also malignant mixed Müllerian tumor], undifferentiated/dedifferentiated...
Abstract Background Homologous recombination deficiency (HRD) is a phenotype that characterized by the inability of cell to effectively repair DNA double-strand breaks using homologous (HRR) pathway. Loss-of-function genes involved in this pathway can sensitize tumors poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors and platinum-based chemotherapy, which target destruction cancer cells working concert with HRD through synthetic lethality. However, identify patients these...
The NCCN Guidelines for Cervical Cancer provide recommendations all aspects of management cervical cancer, including the diagnostic workup, staging, pathology, and treatment. guidelines also include details on histopathologic classification cancer regarding features, molecular profiles, clinical outcomes. treatment landscape advanced is evolving constantly. These Insights a summary recent updates systemic therapy recurrent or metastatic disease.
We conducted an integrated population-based analysis of histologic subtype-specific cervical cancer incidence, survival, and incidence-based mortality by race ethnicity, with correction for hysterectomy prevalence.
Vulvar cancer is annually diagnosed in an estimated 6,470 individuals and the vast majority are histologically squamous cell carcinomas. accounts for 5% to 8% of gynecologic malignancies. Known risk factors vulvar include increasing age, infection with human papillomavirus, cigarette smoking, inflammatory conditions affecting vulva, immunodeficiency. Most neoplasias at early stages. Rarer histologies exist melanoma, extramammary Paget’s disease, Bartholin gland adenocarcinoma, verrucous...
Abstract The glycosyltransferase ST6Gal-I, which adds α2-6–linked sialic acids to substrate glycoproteins, has been implicated in carcinogenesis; however, the nature of its pathogenic role remains poorly understood. Here we show that ST6Gal-I is upregulated ovarian and pancreatic carcinomas, enriched metastatic tumors, associated with reduced patient survival. Notably, upregulation cancer cells conferred hallmark stem-like cell (CSC) characteristics. Modulating expression directly altered...
Ketogenic diets (KDs) are gaining attention as a potential adjuvant therapy for cancer, but data limited KDs’ effects on quality of life. We hypothesized that the KD would (1) improve mental and physical function, including energy levels, (2) reduce hunger, (3) diminish sweet starchy food cravings in women with ovarian or endometrial cancer. Participants were randomized to (70:25:5 from fat, protein, carbohydrate) American Cancer Society diet (ACS: high-fiber, lower-fat). Questionnaires...
Background Obesity is a major risk factor for renal cancer, yet our understanding of its effects on antitumor immunity and immunotherapy outcomes remains incomplete. Deciphering these associations critical, given the growing clinical use immune checkpoint inhibitors metastatic disease mounting evidence an obesity paradox in context cancer immunotherapies, wherein obese patients with have improved outcomes. Methods We investigated between host anti-programmed cell death (PD-1)-based both...
Next-generation sequencing and tumor testing to direct therapy in advanced/recurrent endometrial cancer are frequently used, but the impact of this approach is unclear. We sought confirm proportion patients with at least 1 actionable alteration whether use molecularly targeted was associated improved survival metastatic cancer. A multidisciplinary consortium formed study treatment therapies Tumor therapeutic decisions were physician's recommendations. The abstracted data included age, stage,...
Although the association between high surgical volume and improved outcomes from procedures is well described, mechanisms that underlie this are uncertain. There growing recognition high-volume hospitals may not necessarily have lower complication rates but rather be better at rescuing patients with complications. We examined role of complications, failure to rescue mortality based on hospital for ovarian cancer.The Nationwide Inpatient Sample was used identify women who underwent surgery...
Basal-like breast cancers (BLBC) are poorly differentiated and display aggressive clinical behavior. These tumors become resistant to cytotoxic agents, tumor relapse has been attributed the presence of cancer stem cells (CSC). One pathways involved in CSC regulation is Wnt/β-catenin signaling pathway. LRP6, a Wnt ligand receptor, one critical elements this pathway could potentially be an excellent therapeutic target. Niclosamide shown inhibit by causing degradation LRP6. TRA-8, monoclonal...