A5087220330- Archaeology and ancient environmental studies
- Renal cell carcinoma treatment
- Archaeology and Natural History
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Leprosy Research and Treatment
- Ureteral procedures and complications
- Historical and Cultural Archaeology Studies
- Urologic and reproductive health conditions
- Pediatric Urology and Nephrology Studies
- Renal and Vascular Pathologies
- Cancer Genomics and Diagnostics
- Organ Donation and Transplantation
- Cardiac Valve Diseases and Treatments
- Botany, Ecology, and Taxonomy Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Pleistocene-Era Hominins and Archaeology
- Cardiac Structural Anomalies and Repair
- Tuberculosis Research and Epidemiology
- Kidney Stones and Urolithiasis Treatments
- Immunodeficiency and Autoimmune Disorders
University of Pittsburgh
2020-2025
University of Iowa
2015-2024
University of Pittsburgh Medical Center
2019-2024
University of Iowa Hospitals and Clinics
2016-2024
Iowa City VA Health Care System
2024
University Hospitals of Cleveland
2024
Case Western Reserve University
2024
Saint Thomas Midtown Hospital
2024
Newcastle University
2022-2023
Osteoporosis Canada
2016-2023
Many factors influence the assembly of fibronectin into an insoluble fibrillar extracellular matrix. Previous work demonstrated that one component in serum promotes is lysophosphatidic acid (Zhang, Q., W.J. Checovich, D.M. Peters, R.M. Albrecht, and D.F. Mosher. 1994. J. Cell Biol. 127:1447–1459). Here we show C3 transferase, inhibitor low molecular weight GTP-binding protein Rho, blocks binding 70-kD NH2-terminal fragment to cells matrix induced by or acid. Microinjection recombinant,...
Cholesterol is eliminated from neurons by oxidization, which generates oxysterols. oxidation mediated the enzymes cholesterol 24-hydroxylase (CYP46A1) and 27-hydroxylase (CYP27A1). Immunocytochemical studies show that CYP46A1 CYP27A1 are expressed in some astrocytes normal brain, present oligodendrocytes. In Alzheimer's disease (AD), shows prominent expression around amyloid plaques, whereas decreases not apparent plaques but increases Although previous have examined effects of synthetic...
Abstract Due to problems with primary tumor cell culture, conventional cytogenetics has yielded little insightful information on chromosomal alterations in prostate cancer. The aim of this study was define the ability comparative genomic hybridization (CGH) detect and map genetic deletions tumors. A secondary apply multiple assays individual tumors as a means deciphering mechanisms CGH results were compared allelic imbalance measurements at 29 distinct loci chromosome 8 18 specimens (17...
Background Obesity is a major risk factor for renal cancer, yet our understanding of its effects on antitumor immunity and immunotherapy outcomes remains incomplete. Deciphering these associations critical, given the growing clinical use immune checkpoint inhibitors metastatic disease mounting evidence an obesity paradox in context cancer immunotherapies, wherein obese patients with have improved outcomes. Methods We investigated between host anti-programmed cell death (PD-1)-based both...
Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with activity that was using our genomics platform. We implemented rational design approach to identify potent and selective ACE2 inhibitors. To this end, picomolar inhibitors of were designed synthesized.
Journal Article Media Literacy Perspectives Get access James A. Brown 1Telecommunication and Film Department, University of Alabama, USA Search for other works by this author on: Oxford Academic Google Scholar Communication, Volume 48, Issue 1, March 1998, Pages 44–57, https://doi.org/10.1111/j.1460-2466.1998.tb02736.x Published: 07 February 2006
Unequaled in North America as a single source of prehistoric figurative and decorative art, the Craig burial mound was plundered by commercial diggers 1933. Hundreds fragile shell artifacts covered with engraved designs were quickly sold and, whole or fragmented, scattered public private collections across country. For past ten years, Dr. Philip Phillips, Honorary Curator Southeastern Archaeology at Harvard, has supervised massive project that involved making rubbings line drawings this...
Unexpected ruptures in material culture patterning present interpretive challenges for archaeological narratives of social change. The concept the event, as proposed by William Sewell Jr., offers a robust theoretical vocabulary understanding sudden appearance novel patterning. defines historical events sequences happenings or occurrences that transform structures creating durable between resources and their associated virtual schemas. Thus conceived, occur three phases: (1) sequence...
Abstract Formal analysis is employed to express symbolically the behavior associated with disposal of dead in archaeological contexts. Key diagrams are shown economically partitioning attribute space by a series variables coded on independently measured dimensions. The attention this paper explicate formal-structural relations among materials from Spiro, specialized Mississippian period site eastern Oklahoma, without resort analogies between cultural-historical configurations. power extended...
Parathyroid hormone and calcium were measured in plasma taken from pregnant women at term the umbilical veins of their infants birth. Three assays used to measure parathyroid hormone, a cytochemical bioassay bioactivity two immunoradiometric assays, one specific for amino terminus, other carboxy terminus molecule. Plasma was significantly higher than mothers. Maternal both slightly raised, but value normal; these findings supported view that late pregnancy is time mild physiological...
Existing anticancer strategies focused on disrupting integrin functions in tumor cells or tumor-involved endothelial have met limited success. An alternative strategy is to augment integrin-mediated pathways that suppress progression, but how integrins can signal restrain malignant behavior remains unclear. To address this issue, we generated an vivo model of prostate cancer metastasis via depletion α3β1 integrin, a correlation observed significant proportion cancers. Our data describe...
No AccessJournal of UrologyClinical Urology: Female Urology1 Apr 1999SUPRAMEATAL TRANSVAGINAL URETHROLYSIS STEVEN P. PETROU, JAMES A. BROWN, and JERRY G. BLAIVAS PETROUSTEVEN PETROU , BROWNJAMES BROWN BLAIVASJERRY View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)61655-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We describe assess a method urethrolysis using transvaginal...
Metanephric adenoma has recently been recognized as a unique renal tumor characterized by an unusual degree of cellular differentiation and maturation. We studied metanephric using metaphase analysis observed concomitant chromosome Y loss 7 17 gain. To determine if these chromosomal anomalies are consistently present in adenoma, we all 11 tumors the pathology tissue registry at our institution fluorescence situ hybridization (FISH).FISH, deoxyribonucleic acid probes for chromosomes 1, 7, 8,...