A5065726740- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Ultrasound Imaging and Elastography
- Ultrasonics and Acoustic Wave Propagation
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urological Disorders and Treatments
- Photoacoustic and Ultrasonic Imaging
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Cardiovascular Function and Risk Factors
- Ultrasound and Hyperthermia Applications
- ECG Monitoring and Analysis
- Renal cell carcinoma treatment
- Hormonal and reproductive studies
- Advanced X-ray and CT Imaging
- Cardiac Imaging and Diagnostics
- Urinary Bladder and Prostate Research
- Non-Destructive Testing Techniques
- Flow Measurement and Analysis
- Geophysical Methods and Applications
- Medical Imaging Techniques and Applications
- Urologic and reproductive health conditions
- Advanced Fluorescence Microscopy Techniques
- Radiomics and Machine Learning in Medical Imaging
Washington University in St. Louis
1992-2025
Cleveland Clinic
2019-2024
Cerner (United States)
2023
Kidney Centre
2023
University of California, San Francisco
2018-2022
James A. Haley Veterans' Hospital
2021
University of Iowa
2015-2020
Cleveland Clinic Lerner College of Medicine
2019-2020
Royal Brisbane and Women's Hospital
2018-2019
University Heights Center
2019
Images produced in emission tomography with the expectation-maximization algorithm have been observed to become more noisy and large distortions near edges as iterations proceed images converge towards maximum-likelihood estimate. It is our conclusion that these artifacts are fundamental reconstructions based on estimation it has applied usually; they not due use of algorithm, which but one numerical approach for finding In this paper, we develop a mathematical suppressing both noise edge by...
Improvements in high speed electronics and scintillation-crystal technology now permit usable differential time-of-flight measurements to be made tomography systems that employ coincidence detection of the annihilation photons created with positron emitting radionuclides. A mathematical model for these new is developed this paper. Reconstruction algorithms their signal-to-noise ratio performance are given.
We have shown previously that the physical properties of myocardium in dogs can be characterized with quantitative ultrasonic integrated backscatter and interrogation tissue ultrasound delineate cardiac cycle-dependent changes normal disappear ischemia reappear reperfusion if functional integrity is restorable. To determine whether this approach applied to man, we implemented an automatic gain compensation continuous data acquisition system characterize detect real time. developed a...
We have shown previously that the physiologic, mechanical cardiac cycle is associated with a parallel, cycle-dependent variation of integrated backscatter (IB). However, mechanisms responsible are not known. The mathematical and physiological considerations explored in present study suggest relationship between myocardial contractile function reflects cyclic alterations myofibrillar elastic parameters, juxtaposition intracellular extracellular elements different intrinsic acoustic impedances...
We have recently shown that the cardiac cycle-dependent variation in myocardial ultrasonic integrated backscatter is blunted with regional ischemia dogs. To determine if global and intramural contractile performance can be quantified by backscatter, we analyzed responses after induction of increased decreased contractility five A developed analog data-acquisition system for measuring real time was used to sample radiofrequency signals gated from subepicardial or subendocardial regions....
We have shown recently that tissue characterization of myocardium with ultrasound reflects changes associated contractile function throughout the cardiac cycle. To determine whether ultrasonic can sensitively detect impact ischemic injury and reperfusion on properties heart, we studied time course change backscatter after 5, 20, 60 min coronary occlusion followed by in 15 dogs. The time-averaged integrated (IB) amplitude phase cyclic variation IB (phase relative to left ventricular pressure...
A custom designed system employing advanced communication techniques<R>1,2</R> and unique video displays<R>3</R> for computer-based patient monitoring (see Figure 1) has been built by the Washington University Biomedical Computer Laboratory in cooperation with Department of Surgery Barnes Hospital. Planning system, specifically hospital's four-bed Cardiothoracic Surgical Intensive Care Unit, began 1971, completed was installed March 1973.
No AccessJournal of UrologyAdult Urology1 May 2020Multi-Institution Evaluation Sequential Gemcitabine and Docetaxel as Rescue Therapy for Nonmuscle Invasive Bladder CancerThis article is commented on by the following:Editorial Comment Ryan L. Steinberg, Lewis J. Thomas, Nathan Brooks, Sarah Mott, Andrew Vitale, Trafford Crump, Mounica Y. Rao, Marcus Daniels, Jonathan Wang, Supriya Nagaraju, William C. DeWolf, Donald Lamm, Max Kates, M. Eric Hyndman, Ashish Kamat, Trinity Bivalacqua, Kenneth...
The aim of this paper is to report a method atherosclerotic plaque tissue characterisation based on pattern recognition and assess its accuracy under conditions potential clinical relevance.Excised saline infused human arteries were imaged using IVUS with RF acquisition. 40% the vessels re-imaged blood infusion. A database approximately 12000 image regions-of-interest (ROIs) histologically established types was used design algorithm predict type given ROI by comparing RF-spectrum against...
A controlled study of the effects pulmonary arterial, left auricular, pleural and intrapulmonary pressures on vascular resistance in live dogs was carried out. More than 350 pressure-flow curves were obtained from 10 dogs, using a vertical tube apparatus for perfusion lung with dog's own blood. The data permit quantitation changes resulting each four pressure parameters. In general, fell response to elevation either arterial or auricular pressures. Positive inflation invariably produced...
No AccessJournal of UrologyAdult Urology1 Mar 2020Large Single Institution Comparison Perioperative Outcomes and Complications Open Radical Cystectomy, Intracorporeal Robot-Assisted Cystectomy Robotic Extracorporeal ApproachThis article is commented on by the following:Editorial CommentEditorial Comment JJ H. Zhang, Kyle J. Ericson, Lewis Thomas, Jacob Knorr, Abhinav Khanna, Alice Crane, Ria Mittal, Anna Zampini, Michele Fascelli, Prithvi B. Murthy, Georges-Pascal Haber, Byron Lee ZhangJJ...
Background Obesity is a major risk factor for renal cancer, yet our understanding of its effects on antitumor immunity and immunotherapy outcomes remains incomplete. Deciphering these associations critical, given the growing clinical use immune checkpoint inhibitors metastatic disease mounting evidence an obesity paradox in context cancer immunotherapies, wherein obese patients with have improved outcomes. Methods We investigated between host anti-programmed cell death (PD-1)-based both...
Phased-array imaging, including complete dynamic focus, is explored for imaging using a circular aperture. Based on the constraints of catheter-based systems, an efficient synthetic aperture method has been developed single wire connection between array and external electronics. The employs highly sampled with element pitch small compared to acoustic wavelength. On any given firing array, however, large number channels are electrically connected both transmission reception. From firing, one...
The frame rate in medical ultrasound imaging may be increased significantly by reducing the number of transmit firings per image frame. Cooley et al. (1994) and Lockwood (1995) have described synthetic aperture systems where each is imaged using data obtained from a small elements fired succession. These "synthetic aperture" potential for very high rates, but they also suffer low SNR. Here, authors present method increasing SNR such spatially-encoded transmits. transmitted power having...
Bacillus Calmette-Guerin (BCG) is the most effective intravesical therapy for non-muscle invasive bladder cancer (NMIBC), but patients can fail or supply shortages develop. For BCG failures, radical cystectomy recommended. However, in who desire preservation are poor surgical candidates, alternative salvage therapies should be explored.To determine whether dual sequential gemcitabine and docetaxel treating NMIBC.We evaluated our initial experience with 45 treated between June 2009 May 2014....
The inverse problem involving the determination of a three-dimensional biological structure from images obtained by means optical-sectioning microscopy is ill posed. Although linear least-squares solution can be rapidly filtering, we show here that it unstable because inversion small eigenvalues microscope's point-spread-function operator. We have regularized application linear-precision-gauge formalism Joyce and Root [ J. Opt. Soc. Am. A1, 149 ( 1984)]. In our method being constrained to...
Pulmonary vascular resistance was studied as a function of both transpulmonary pressure and lung volume, using excised dog lungs inflated by lowering pleural perfused with fresh, heparinized blood. The absolute magnitude the pressures kept constant. Measurements were taken under static conditions. In all cases, found to be lowest at approximately half maximal volume showed progressive rise on either further inflation or deflation. Also, course vary significantly according history, especially...
Prostatic adenocarcinoma with cribriform morphology and/or intraductal carcinoma has higher recurrence and mortality rates after radiation surgery. While the prognostic impact of these features is well studied, concordance on biopsy prostatectomy only recently gained attention. Our primary objective was to evaluate diagnostic performance detect in paired specimens a large contemporary cohort.Patients who underwent prostate or had biopsies reviewed prior at tertiary hospital between November...
We tested the most complete optical model available for computational optical-sectioning microscopy and obtained four main results. First, we observed good agreement between experimental theoretical point-spread functions (PSF∙s) under a variety of imaging conditions. Second, using these PSF's, found that linear restoration method yielded reconstructed images well-defined phantom object (a 10-μm-diameter fluorescent bead) closely resembled theoretically determined, best-possible...
Abstract Background: Prostate cancer (PCa) progression has been shown to be influenced by the relationship of extracellular matrix (ECM) proteins within stroma, and immune tumor cells. However, current standard care for PCa patients does not take these factors into account. Previously, our team identified sets ECM glycans using matrix-assisted laser desorption/ionization (MALDI) imaging that were associated with PCa. We also found preliminary evidence MALDI can guide pathomic textural...
This paper presents a theoretical comparison of three generic sampled aperture ultrasonic imaging systems for nondestructive evaluation. The are categorized according to their source-receiver combination data acquisition: common-source, back-scatter, and full-array imaging. First, forward modeling is performed point source receiver. then used model the received set each categories. Subsequently, inversion algorithm category derived, performance evaluated in terms resolution, noise,...