A5001774464- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac electrophysiology and arrhythmias
- Cerebrovascular and Carotid Artery Diseases
- Climate Change and Health Impacts
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Lipoproteins and Cardiovascular Health
- Spectroscopy Techniques in Biomedical and Chemical Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Circadian rhythm and melatonin
- Photoacoustic and Ultrasonic Imaging
- Cardiac Arrest and Resuscitation
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Effects of Exercise
- Heart Failure Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Optical Imaging and Spectroscopy Techniques
- Blood properties and coagulation
Harvard University
2005-2025
Brigham and Women's Hospital
2004-2025
MedStar Washington Hospital Center
2019
Universitätsmedizin Göttingen
2019
Cardiovascular Research Foundation
2014-2018
Boston University
1999-2017
Massachusetts General Hospital
2000-2017
Spectrum Health
2013-2017
Wake Forest University
2017
Infrared Laboratories (United States)
2007-2016
To determine whether the onset of myocardial infarction occurs randomly throughout day, we analyzed time pain in 2999 patients admitted with infarction. A marked circadian rhythm frequency was detected, a peak from 6 a.m. to noon (P<0.01). In 703 patients, first elevation plasma creatine kinase MB (CK-MB) level could be used objectively. CK-MB—estimated timing confirmed existence rhythm, threefold increase at (9 a.m.) as compared trough (11 p.m.) periods. The not detected receiving...
Background —Elevated concentrations of ambient particulate air pollution have been associated with increased hospital admissions for cardiovascular disease. Whether high particles can trigger the onset acute myocardial infarction (MI), however, remains unknown. Methods and Results —We interviewed 772 patients MI in greater Boston area between January 1995 May 1996 as part Determinants Myocardial Infarction Onset Study. Hourly particle mass <2.5 μm (PM 2.5 ), carbon black, gaseous...
To determine whether sudden cardiac death exhibits a circadian rhythm similar to that recently demonstrated for nonfatal myocardial infarction, we analyzed the time of day as indicated by certificates 2203 individuals dying out hospital in Massachusetts 1983. The data reveal prominent variation death, with low incidence during night and an increased from 7 11 A.M. pattern is remarkably reported infarction episodes ischemia. finding frequency morning compatible hypotheses results ischemia or...
Background —Marijuana use in the age group prone to coronary artery disease is higher than it was past. Smoking marijuana known have hemodynamic consequences, including a dose-dependent increase heart rate, supine hypertension, and postural hypotension; however, whether can trigger onset of myocardial infarction unknown. Methods Results —In Determinants Myocardial Infarction Onset Study, we interviewed 3882 patients (1258 women) with acute an average 4 days after onset. We used...
Background Many anecdotes and several uncontrolled case series have suggested that emotionally stressful events, more specifically, anger, immediately precede appear to trigger the onset of acute myocardial infarction. However, controlled studies determine relative risk infarction after episodes anger not been reported. Methods Results We interviewed 1623 patients (501 women) an average 4 days The interview identified time, place, quality pain other symptoms, estimated usual frequency during...
Background —Cocaine has been implicated as a trigger of acute myocardial infarction in patients with and those without underlying coronary atherosclerosis. However, the magnitude increase risk immediately after cocaine use remains unknown. Methods Results —In Determinants Myocardial Infarction Onset Study, we interviewed 3946 (1282 women) an average 4 days onset. Data were collected on other potential triggers infarction. We compared reported hour preceding onset symptoms its expected...
We report clinical experience with the coronary vasodilator nifedipine in 127 patients symptoms of myocardial ischemia associated electrocardiographic or angiographic evidence, both, coronary-artery spasm. In majority conventional antianginal therapy including nitrates and beta-adrenergic blockers failed, one third at least episode ventricular tachycardia developed during an attack angina. Nifedipine (40 to 160 mg every 24 hours) significantly reduced mean weekly rate anginal attacks from 16...
Background— Percutaneous coronary intervention (PCI) is associated with periprocedural myocardial infarction (MI) in 3% to 15% of cases (depending on the definition used). In many cases, these MIs result from distal embolization lipid-core plaque (LCP) constituents. Prospective identification LCP catheter-based near-infrared spectroscopy (NIRS) may predict an increased risk MI and facilitate development preventive measures. Methods Results— The present study analyzed relationship between...