A5103577203- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Mycobacterium research and diagnosis
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Genetics, Aging, and Longevity in Model Organisms
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Protein Kinase Regulation and GTPase Signaling
- Cervical Cancer and HPV Research
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Vasculitis and related conditions
- Viral-associated cancers and disorders
- Glycosylation and Glycoproteins Research
- Protease and Inhibitor Mechanisms
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Liver Disease and Transplantation
Federal Ministry of Health
2021-2024
Ahfad University for Women
2018-2024
Weill Cornell Medical College in Qatar
2012-2022
University of Gezira
2017
Hamad Medical Corporation
2012-2016
Brown University
2012-2013
Genomics (United Kingdom)
2013
National Institutes of Health
2012
Massachusetts General Hospital
2005-2007
Harvard University
2005-2007
The propensity to develop atherosclerosis varies markedly among different sites in the human vasculature. To determine a possible cause for such differences susceptibility, proteomics-based approach was used assess extracellular proteoglycan core protein composition of intimal hyperplasia from both atherosclerosis-prone internal carotid artery and atherosclerosis-resistant thoracic artery. these preatherosclerotic lesions found be more complex than previously appreciated with up eight...
Abstract Although the linkage between germline mutations of BRCA1 and hereditary breast/ovarian cancers is well established, recent evidence suggests that altered expression wild-type might contribute to sporadic forms breast cancer. The cancer gene trinucleotide-repeat-containing 9 (TNRC9; TOX3) has been associated with disease susceptibility but its function undetermined. Here, we report TNRC9 often amplified overexpressed in cancer, particularly advanced Gene amplification was reduced...
Breast cancer is the most common malignancy accounting for 25% of all cancers in females. In Africa, breast prevalence and mortality are steadily increasing. Knowledge hormone receptors human epidermal growth factor receptor-2 (HER-2) expressions vital management plans decision making. There wide regional variation proportion these biomarkers, especially African countries. Hormone positivity indigenous American women considered to be low triple negative a dominant phenotype. paucity data...
Abstract Breast cancer largely dominates the global burden statistics; however, there are striking disparities in mortality rates across countries. While socioeconomic factors contribute to population-based differences mortality, they do not fully explain disparity among women of African ancestry (AA) and Arab (ArA) compared European (EA). In this study, we sought identify molecular that could provide insight into biology ancestry-associated clinical outcomes. We applied a unique approach...
Cervical cancer is the fourth most common in women worldwide with highest incidence reported Eastern Africa 2012. The primary goal of this study was to expression p16INK4a squamous cell carcinoma (SCC) cervix by immunohistochemistry (IHC) and determine relation clinico-pathological parameters. This further explored correlation immunostaining another proliferation marker, Ki-67 if human papillomavirus (HPV) IHC can be used as a marker for detection virus high-grade dysplasia.A total 90...
Giant cell arteritis (GCA) affecting the cranial arteries is a disease of unknown cause that causes blindness, stroke, and other morbidity. Its sudden onset segmental distribution are suggestive diseases involve viral reactivation, known to be innervated by ganglia harbor herpes simplex virus (HSV). We used high-sensitivity polymerase chain reaction assay test for HSV DNA in specimens from 39 consecutive temporal artery biopsies performed suspected GCA. was detected 21 (88%) 24...
Abstract In a cross-sectional survey in Omdurman, Sudan, during March–April 2021, we estimated that 54.6% of the population had detectable severe acute respiratory syndrome coronavirus 2 antibodies. Overall death rates among those >50 years age increased 74% over first disease pandemic year.
Abstract Background Advances in our understanding of the tumor microenvironment have radically changed cancer field, highlighting emerging need for biomarkers an active, favorable immune phenotype to aid treatment stratification and clinical prognostication. Numerous immune-related gene signatures been defined; however, their prognostic value is often limited one or few types. Moreover, area non-coding RNA as remains largely unexplored although number biological roles are rapidly expanding....
<ns4:p>The increased application of high-throughput approaches in translational research has expanded the number publicly available data repositories. Gathering additional valuable information contained datasets represents a crucial opportunity biomedical field. To facilitate and stimulate utilization these datasets, we have recently developed an interactive browsing visualization web application, Gene Expression Browser (GXB). In this note, describe curated compendium 13 public on human...
ABSTRACT This report presents the first genomes from positive cases of cholera in Sudan. Genomic analysis 10 Vibrio cholerae isolates, profiled as serogroup O1, reveals evidence antimicrobial resistance genes and a 139-kb IncC plasmid with 99.74% identity to multidrug-resistant pCNRVC190243 previously reported Yemen Lebanon.
The increased application of high-throughput approaches in translational research has expanded the number publicly available data repositories. Gathering additional valuable information contained datasets represents a crucial opportunity biomedical field. To facilitate and stimulate utilization these datasets, we have recently developed an interactive browsing visualization web application, Gene Expression Browser (GXB). In this note, describe curated compendium 13 public on human breast...
Purpose The objective of this study was to compare tumor characteristics, biomarkers, and surrogate subtypes breast cancer between Sudanese German women. Methods Tumor characteristics immunohistochemistry markers (estrogen receptor [ER], progesterone [PR], human epidermal growth factor 2 [HER2]) were collected from the routine assessment consecutive patients with invasive diagnosed 2010 2015 (Gezira University Pathology Laboratory, Gezira, Sudan) 1999 2013 (Breast Centre,...
Vitamin D deficiency is a worldwide concern. The aim of the current study was to determine vitamin level and its contributing factors in Sudanese women.In this cross-sectional study, 251 women attending Family Health Centers Khartoum, Sudan were interviewed. Following exclusion confounding factors, samples from 190 analzsed. Serum 25 hydroxyvitamin "25(OH) D" quantified using competitive electrochemiluminescence immunoassay.Participants' age ranged 18 85 years with mean (±SD) 40.2 (±14.06)...
Breast Cancer in the Middle East and North Africa region (MENA) occurs a younger age group of patients is more aggressive than Europe America. Little known about presence immune infiltration clinico-pathologic correlates from MENA region. Immune most solid tumors carries prognostic role. Adaptive cells cytotoxic T-cells, particular, play positive role undergoing treatment for breast cancer. Therefore, our preliminary study was aimed to identify quantify tumor infiltrating lymphocytes (TILs)...
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