Davide Bedognetti
A5071591293- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Graphene and Nanomaterials Applications
- Melanoma and MAPK Pathways
- Single-cell and spatial transcriptomics
- Lymphoma Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Bioinformatics and Genomic Networks
- Monoclonal and Polyclonal Antibodies Research
- Neuroblastoma Research and Treatments
- Colorectal Cancer Treatments and Studies
- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- MXene and MAX Phase Materials
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Nutrition, Genetics, and Disease
- Radiomics and Machine Learning in Medical Imaging
Qatar Airways (Qatar)
2014-2025
University of Genoa
2010-2025
Ospedale Policlinico San Martino
2024-2025
Kite (United States)
2024-2025
Sidra Medical and Research Center
2014-2024
Hamad bin Khalifa University
2017-2024
The University of Queensland
2024
Westmead Institute for Medical Research
2024
University of Münster
2024
Qatar Foundation
2017-2023
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled TCGA. Across types, we identified six immune subtypes—wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant—characterized differences in macrophage or signatures, Th1:Th2 cell ratio, extent intratumoral heterogeneity, aneuploidy, neoantigen load, overall proliferation, expression immunomodulatory genes,...
Mounting evidence supports a role for the immune system in breast cancer outcomes. The ability to distinguish highly immunogenic tumors susceptible anti-tumor immunity from weakly or inherently immune-resistant would guide development of therapeutic strategies cancer. Genomic, transcriptomic and clinical data Cancer Genome Atlas (TCGA) Molecular Taxonomy Breast International Consortium (METABRIC) cohorts were used examine statistical associations between tumor mutational burden (TMB)...
Abstract In tumor-bearing mice, cyclic fasting or fasting-mimicking diets (FMD) enhance the activity of antineoplastic treatments by modulating systemic metabolism and boosting antitumor immunity. Here we conducted a clinical trial to investigate safety biological effects cyclic, five-day FMD in combination with standard therapies. 101 patients, was safe, feasible, resulted consistent decrease blood glucose growth factor concentration, thus recapitulating metabolic changes that mediate...
The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification accurate biomarkers clinical outcome. In this cohort study, we performed comprehensive genomic analyses on fresh-frozen samples from 348 patients affected by primary colon cancer, encompassing RNA, whole-exome, deep T cell receptor and 16S bacterial rRNA gene sequencing tumor matched healthy tissue, complemented whole-genome for further microbiome characterization. A type 1 helper cell,...
Abstract The phase 3 ZUMA-7 trial in second-line large B cell lymphoma demonstrated superiority of anti-CD19 CAR T therapy (axicabtagene ciloleucel (axi-cel)) over standard care (SOC; salvage chemotherapy followed by hematopoietic transplantation) ( NCT03391466 ). Here, we present a prespecified exploratory analysis examining the association between pretreatment tumor characteristics and efficacy axi-cel versus SOC. gene expression signature (GES) CD19 associated significantly with improved...
Cancer immunotherapy is revolutionizing the clinical management of several tumors, but has demonstrated limited activity in breast cancer. The development more effective treatments hindered by incomplete knowledge genetic determinant immune responsiveness. To fill this gap, we mined copy number alteration, somatic mutation, and expression data from Genome Atlas (TCGA). By using RNA-sequencing 1,004 cancers, defined distinct phenotypes characterized progressive transcripts previously...
Ultrasonography is a fundamental diagnostic imaging tool in everyday clinical practice. Here, we are unique describing the use of functionalized multiwalled carbon nanotubes (MWCNTs) as hyperechogenic material, suggesting their potential application ultrasound contrast agents. Initially, carried out thorough investigation to assess echogenic property vitro. We demonstrated long-lasting properties. also showed that signal MWCNTs higher than graphene oxide, pristine MWCNTs, and single-walled...
Adoptive therapy with tumour-infiltrating lymphocytes (TILs) induces durable complete responses (CR) in ∼20% of patients metastatic melanoma. The recruitment T cells through CXCR3/CCR5 chemokine ligands is critical for immune-mediated rejection. We postulated that polymorphisms and/or expression TILs and the their tumour influence migration to tumours regression. Tumour-infiltrating from 142 melanoma enrolled adoptive trials were genotyped CXCR3 rs2280964 CCR5-Δ32 deletion, which encodes a...
Abstract Understanding the biomolecular interactions between graphene and human immune cells is a prerequisite for its utilization as diagnostic or therapeutic tool. To characterize complex cells, we propose an integrative analytical pipeline encompassing evaluation of molecular cellular parameters. Herein, use single-cell mass cytometry to dissect effects oxide (GO) GO functionalized with amino groups (GONH 2 ) on 15 cell populations, interrogating 30 markers at level. Next, integration...