A5066723560- Complement system in diseases
- Chromatin Remodeling and Cancer
- Monoclonal and Polyclonal Antibodies Research
- Mechanisms of cancer metastasis
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Cancer Mechanisms and Therapy
- Protein Degradation and Inhibitors
- Blood Coagulation and Thrombosis Mechanisms
- Multiple Myeloma Research and Treatments
- Genomics and Chromatin Dynamics
- Ferroptosis and cancer prognosis
- Platelet Disorders and Treatments
- Cancer Genomics and Diagnostics
- RNA regulation and disease
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Connexins and lens biology
- interferon and immune responses
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Corneal Surgery and Treatments
- HER2/EGFR in Cancer Research
- Diet and metabolism studies
- Cancer therapeutics and mechanisms
- Caveolin-1 and cellular processes
Biocon (India)
2025
Rutgers Cancer Institute of New Jersey
2017-2023
Johnson University
2019-2023
Rutgers, The State University of New Jersey
2017-2023
AbbVie (United States)
2018-2021
Institute of Chemical Technology
2021
University of Colorado Anschutz Medical Campus
2014-2020
University of Toledo
2013-2017
University of Colorado Denver
2009-2017
Fukushima Medical University
2016
Mounting evidence supports a role for the immune system in breast cancer outcomes. The ability to distinguish highly immunogenic tumors susceptible anti-tumor immunity from weakly or inherently immune-resistant would guide development of therapeutic strategies cancer. Genomic, transcriptomic and clinical data Cancer Genome Atlas (TCGA) Molecular Taxonomy Breast International Consortium (METABRIC) cohorts were used examine statistical associations between tumor mutational burden (TMB)...
Interactions between the microbiota and distal gut are important for maintenance of a healthy intestinal barrier; dysbiosis microbial communities has emerged as likely contributor to diseases that arise at level mucosa. Intraepithelial lymphocytes (IELs) positioned within epithelial barrier, in small intestine they function maintain homeostasis. We hypothesized colon IELs promote barrier through expression cytokines response interactions with commensal bacteria. Profiling bacterial 16S...
Citrullination of joint proteins by the protein arginine deiminase (PAD) family enzymes is recognized increasingly as a key process in pathogenesis rheumatoid arthritis. This present study was undertaken to explore efficacy novel PAD4-selective inhibitor, GSK199, murine collagen-induced arthritis model Mice were dosed daily from time collagen immunization with GSK199. Efficacy assessed against wide range end-points, including clinical disease scores, histology and immunohistochemistry, serum...
The complement system is a key component of innate immunity implicated in the neutralization and clearance invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle promising magnetic resonance imaging (MRI) contrast agent. However, dextran SPIO has been associated with significant number complement-related side effects patients some agents have discontinued from clinical use (e.g., Feridex™). In order to improve safety these materials, mechanisms activation by...
Mutations in SOX10 cause neurocristopathies which display varying degrees of hypopigmentation. Using a sensitized mutagenesis screen, we identified Smarca4 as modifier gene that exacerbates the phenotypic severity Sox10 haplo-insufficient mice. Conditional deletion expressing cells resulted reduced numbers cranial and ventral trunk melanoblasts. To define requirement for -encoded BRG1 subunit SWI/SNF chromatin remodeling complex, employed vitro models melanocyte differentiation induction...
Nimesulide, a non-steroidal anti-inflammatory drug, was incorporated into multilamellar liposomes to improve its performance on topical administration. The drug loaded onto employing thin film hydration technique. Various process and formulation variables were investigated obtain the liposomal products of desired quality. Liposomes monitored for percent entrapment, after separating unentrapped by mini column centrifugation, vesicular properties (such as size distribution profile,...
Abstract Rheumatoid arthritis (RA) is an inflammatory autoimmune joint disease in which the complement system plays important role. Of several components of complement, current evidence points to C5 as most inducer inflammation. Several groups generated Abs or small interfering RNAs (siRNAs) molecule inhibitors against and C5aR1 (CD88) that have showed some efficacy RA animal models. However, none these candidate therapeutics has moved from bench bedside. In this study, we test collagen...
SOX10 is a Sry-related high mobility (HMG)-box transcriptional regulator that promotes differentiation of neural crest precursors into Schwann cells, oligodendrocytes, and melanocytes. Myelin, formed by cells in the peripheral nervous system, essential for propagation nerve impulses. SWI/SNF complexes are ATP dependent chromatin remodeling enzymes critical cellular differentiation. It was recently demonstrated BRG1 subunit activates expression also interacts with to activate OCT6 KROX20, two...
Abstract Dual bromodomain BET inhibitors that bind with similar affinities to the first and second bromodomains across BRD2, BRD3, BRD4, BRDT have displayed modest activity as monotherapy in clinical trials. Thrombocytopenia, closely followed by symptoms characteristic of gastrointestinal toxicity, presented dose-limiting adverse events may prevented escalation higher dose levels required for more robust efficacy. ABBV-744 is a highly selective inhibitor four family proteins. In contrast...
Abstract Chromosome 11q13-14 amplification is a defining feature of high-risk hormone receptor-positive (HR+) breast cancer; however, the mechanism(s) by which this amplicon contributes to tumorigenesis remains unclear. In current study, proteogenomic analyses >3000 tumors from TCGA, METABRIC and CPTAC studies demonstrated that carnitine palmitoyltransferase 1A (CPT1A), localized amplicon, overexpressed at mRNA protein level in aggressive luminal tumors, strongly associated with...
Previous studies using mannose-binding lectin (MBL) and complement C4-deficient mice have suggested that the pathway (LP) is not required for development of inflammatory arthritis in collagen Ab-induced (CAIA) model. MBL, ficolins collectin-11 are key LP pattern recognition molecules associate with three serine proteases-MASP-1, MASP-2, MASP-3-and two MBL-associated proteins designated sMAP protein 44kDA (MAp44). Recent shown MAp44, an alternatively spliced product MASP-1/3 gene, a...
Aim: Lung carcinoma is the most common malignancy and leading cause of cancer deaths worldwide. Although clinical factors including age, performance status stage influence likelihood benefit from tolerability chemotherapy, genetic profile individual patients may be an independent predictor response toxicity. The present study aimed to identify pharmacogenetic markers associated with toxicity in advanced non-small cell lung (NSCLC) treated primarily carboplatin paclitaxel. Materials &...
Aldehyde dehydrogenase 1A1 (ALDH1A1) and ALDH3A1 are corneal crystallins. They protect inner ocular tissues from ultraviolet radiation (UVR)-induced oxidative damage through catalytic non-catalytic mechanisms. Additionally, has been postulated to play a regulatory role in the epithelium based on several studies that report an inverse association between expression cell proliferation. The underlying molecular mechanisms physiological significance of such remain poorly understood. In current...
Abstract Inhibition of the HER2/ERBB2 receptor is a keystone to treating HER2-positive malignancies, particularly breast cancer, but significant fraction (HER2+) cancers recur or fail respond. Anti-HER2 monoclonal antibodies, like trastuzumab pertuzumab, and ATP active site inhibitors lapatinib, commonly lack durability because adaptive changes in tumor leading resistance. HER2+ cell line responses inhibition with lapatinib were analyzed by RNAseq ChIPseq characterize transcriptional...
Factor H (fH) is an endogenous negative regulator of the alternative pathway (AP) that binds polyanions as well complement activation fragments C3b and C3d. The AP both necessary sufficient to develop collagen Ab-induced arthritis (CAIA) in mice; mechanisms whereby normal control overcome injury develops are unknown. Although primarily a soluble circulating protein, fH can also bind tissues manner dependent on carboxyl-terminal domain containing short consensus repeats 19 20. We examined...
BackgroundDespite toxic side effects and limited durable response, the current standard-of-care treatment for high grade serous ovarian cancer (HGSOC) remains platinum/taxane-based chemotherapy. Given that overall prognosis has not improved drastically over past several decades, there is a critical need to understand underlying mechanisms lead tumour development progression.MethodsWe utilized an integrative proteogenomic analysis of HGSOC tumours applying poor gene expression signature (PPS)...
Abstract The complement system is involved in mediation of joint damage rheumatoid arthritis, with evidence suggesting activation both the classical and alternative pathway (AP). AP necessary sufficient to mediate collagen Ab–induced an experimental animal model immune complex–induced disease. mice dependent on MASP-1/3 cleavage pro–factor D (pro-FD) into mature factor (FD). objectives current study were determine cells synthesizing pro-FD synovial tissue. Collagen arthritis was studied...