A5029835500- Systemic Lupus Erythematosus Research
- Reproductive Biology and Fertility
- Rheumatoid Arthritis Research and Therapies
- Gene expression and cancer classification
- Cancer Genomics and Diagnostics
- Bioinformatics and Genomic Networks
- Cytokine Signaling Pathways and Interactions
- Molecular Biology Techniques and Applications
- Nutrition, Genetics, and Disease
- BRCA gene mutations in cancer
- Ovarian function and disorders
- Bladder and Urothelial Cancer Treatments
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Autoimmune and Inflammatory Disorders Research
- Pancreatic and Hepatic Oncology Research
- Monoclonal and Polyclonal Antibodies Research
- Ovarian cancer diagnosis and treatment
- Proteoglycans and glycosaminoglycans research
- Fatty Acid Research and Health
- Neuroendocrine Tumor Research Advances
- Immunodeficiency and Autoimmune Disorders
- Microscopic Colitis
- Cancer Treatment and Pharmacology
- Lipoproteins and Cardiovascular Health
Massey University
2024-2025
University of Auckland
2013-2024
Maurice Wilkins Centre
2017-2022
Beijing Obstetrics and Gynecology Hospital
2022
Oklahoma Medical Research Foundation
2004-2013
Statistical Research (United States)
2013
University of Oklahoma Health Sciences Center
2008
Seattle Reproductive Medicine
2006
Oklahoma City University
2006
Novartis (Switzerland)
2004
BACKGROUNDThe primary determinant of reproductive age in women is the number ovarian non-growing (primordial, intermediate and primary) follicles (NGFs). To better characterize decline NGF associated with aging, we have employed modern stereology techniques to determine from birth menopause.
Mounting evidence supports a role for the immune system in breast cancer outcomes. The ability to distinguish highly immunogenic tumors susceptible anti-tumor immunity from weakly or inherently immune-resistant would guide development of therapeutic strategies cancer. Genomic, transcriptomic and clinical data Cancer Genome Atlas (TCGA) Molecular Taxonomy Breast International Consortium (METABRIC) cohorts were used examine statistical associations between tumor mutational burden (TMB)...
Background Disease activity measurement is a key component of rheumatoid arthritis (RA) management. Biomarkers that capture the complex and heterogeneous biology RA have potential to complement clinical disease assessment. Objectives To develop multi-biomarker (MBDA) test for arthritis. Methods Candidate serum protein biomarkers were selected from extensive literature screens, bioinformatics databases, mRNA expression microarray data. Quantitative assays identified optimized measuring...
Objectives . Serum cytokines play an important role in the pathogenesis of psoriatic arthritis (PsA) by initiating and perpetuating various cellular humoral autoimmune processes. The aim this study was to describe a broad spectrum T- B-cell cytokines, growth factors chemokines patients with PsA healthy individuals. Methods A novel protein array system, denoted as multiplex cytokine assay utilized measure simultaneously levels 23 circulating Additionally, correlational clustering discriminant...
Serum cytokines play an important role in the pathogenesis of myositis by initiating and perpetuating various cellular humoral autoimmune processes. The aim present study was to describe a broad spectrum T- B-cell cytokines, growth factors chemokines patients with idiopathic inflammatory myopathies (IIMs) healthy individuals.A protein array system, denoted as multiplex cytokine assay utilized measure simultaneously levels 24 circulating including activating factor (BAFF) proliferation...
Serum rheumatoid factor (RF) and other heterophilic antibodies potentially interfere with antibody-based immunoassays by nonspecifically binding detection reagents. The purpose of this study was to assess whether these factors confound multiplex-based immunoassays, which are used increasing frequency measure cytokine chemokine analytes in patients arthritis (RA).We performed multiplex using different platforms analyte concentrations RA patient samples. Samples were depleted RF column-based...
Evofosfamide (TH-302) is a clinical-stage hypoxia-activated prodrug of DNA-crosslinking nitrogen mustard that has potential utility for human papillomavirus (HPV) negative head and neck squamous cell carcinoma (HNSCC), in which tumor hypoxia limits treatment outcome. We report the preclinical efficacy, target engagement, preliminary predictive biomarkers initial clinical activity evofosfamide HPV-negative HNSCC. was assessed 22 genomically characterized lines 7 line–derived xenograft (CDX),...
Pancreatic neuroendocrine tumors (pNETs) are uncommon cancers arising from pancreatic islet cells. Here we report the analysis of gene mutation, copy number, and RNA expression 57 sporadic well-differentiated pNETs. pNET genomes dominated by aneuploidy, leading to concordant changes in at level whole chromosomes chromosome segments. We observed two distinct patterns somatic aneuploidy that associated with tumor pathology patient prognosis. Approximately 26% patients this series had pNETs...
<title>Abstract</title> Accurate prediction of breast cancer-specific survival is crucial for guiding personalized treatment decisions and improving patient outcomes. This study evaluated the performance machine learning approaches (Random Survival Forest, RSF Generalized Boosted Model, GBM) alongside traditional Cox proportional hazards models predicting in 21,574 women diagnosed with stage I-IV cancer New Zealand between 2000-2019. Performance comparisons using time-dependent Area Under...
Background Breast cancer prognosis changes over time in complex ways depending on individual risk factors. This study aimed to analyze how breast outcomes New Zealand women change and identify features associated with specific survival locoregional recurrence across different receptor subtypes. Methods A retrospective cohort was conducted using data from Te Rēhita Mate Ūtaetae (Breast Cancer Foundation National Register) 21,574 diagnosed invasive between 2000-2019. We applied k-medians...
Abstract Objective The cells of the immune system originate from bone marrow, where many them also mature. This study was undertaken to examine gene expression in marrow patients with systemic lupus erythematosus (SLE), order better understand aberrant response this disease. Methods Bone mononuclear (BMMCs) 20 SLE (11 active disease and 9 inactive disease) peripheral blood (PBMCs) 27 (16 11 were studied; BMMCs PBMCs 7 healthy individuals 3 osteoarthritis studied as controls. Samples analyzed...
Abstract Objective We have previously reported a defect in neutrophil activation children with polyarticular juvenile idiopathic arthritis (JIA). The current study was undertaken to determine whether gene expression abnormalities persist JIA remission and use systems biology analysis elucidate pathologic pathways JIA. Methods performed profiling on neutrophils from Children were grouped according disease status. studied 14 active who taking medication, 8 clinical of medication (CRM status),...
Abstract Objective The development of biomarkers to predict response therapy in polyarticular juvenile idiopathic arthritis (JIA) is an important issue pediatric rheumatology. A critical step this process determining whether there biologic meaning clinically derived terms such as “active disease” and “remission.” aim study was use a systems biology approach address question. Methods We performed gene transcriptional profiling on children who fulfilled the criteria for specific disease states...
Intravesical Bacillus Calmette-Guerin (BCG) is an effective treatment for bladder superficial carcinoma and it being tested in interstitial cystitis patients, but its precise mechanism of action remains poorly understood. It not clear whether BCG induces the release a unique set cytokines apart from pro-inflammatory effects. Therefore, we quantified inflammatory responses alterations urinary cytokine protein induced by intravesical compared results to non-specific stimuli (LPS TNF-α). We...
Recent findings indicate that VEGF receptors and coreceptors (neuropilins; NRP) are expressed on nonendothelial cells in human bladder urothelium, one cancer cell line (J82), the mouse urothelium. In addition, VEGFR1, VEGFR2, NRP1, NRP2 expressions were upregulated animal models of chronic inflammation induced by four weekly instillations protease-activated (PAR)-activating peptides or bacillus Calmette-Guérin (BCG) into bladder. Here, we used BCG as a model for to further investigate...
While rheumatoid arthritis (RA) is considered a prototypical autoimmune disease, the specific roles of B-cells in RA pathogenesis not fully delineated.We performed microarray expression profiling peripheral blood from patients and controls. Data were analysed using differential gene analysis 'gene networking' (characterizing clusters functionally inter-relelated genes) to identify both regulatory genes pathways which they participate. Results confirmed by quantitative real-time polymerase...
The first goal of this study was to measure the oxidative stress (OS) and relate it lipoprotein variables in 35 renal patients before dialysis (CKD), 37 on hemodialysis (HD) 63 healthy subjects. method for OS based ratio cholesteryl esters (CE) containing C18/C16 fatty acids (R2) measured by gas chromatography (GC) which is a simple, direct, rapid reliable procedure. second investigate identify triacylglycerol peak GC, referred as TG48 (48 represents sum three carbon chain lengths) markedly...
Abstract Background The extracellular matrix has a major effect upon the malignant properties of bladder cancer cells both in vitro 3-dimensional culture and vivo . Comparing gene expression several lines grown under permissive suppressive conditions growth on cancer-derived normal-derived basement membrane gels respectively plastic conventional tissue provides model system for investigating interaction malignancy matrix. Understanding how affects phenotype may provide important clues to...