A5016405661- Proteoglycans and glycosaminoglycans research
- Bladder and Urothelial Cancer Treatments
- Urinary Bladder and Prostate Research
- Glycosylation and Glycoproteins Research
- Polysaccharides and Plant Cell Walls
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Urinary Tract Infections Management
- Cancer Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Cancer Cells and Metastasis
- Molecular Biology Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Estrogen and related hormone effects
- Gene expression and cancer classification
- Colorectal Cancer Screening and Detection
- Advanced Proteomics Techniques and Applications
- Photodynamic Therapy Research Studies
- Urinary and Genital Oncology Studies
- Blood Coagulation and Thrombosis Mechanisms
- Polysaccharides Composition and Applications
- Epigenetics and DNA Methylation
University of Oklahoma Health Sciences Center
2011-2021
Guy's and St Thomas' NHS Foundation Trust
2021
OU Health
2007-2018
University of Oklahoma
1990-2018
Smith College
2018
Syracuse University
2018
University of Memphis
2018
Texas A&M University
2018
Louisiana State University Health Sciences Center New Orleans
2018
John Wiley & Sons (United States)
2018
No AccessJournal of Urology1 Jan 1990Bladder Surface Glycosaminoglycans: An Epithelial Permeability Barrier L. Parsons, D. Boychuk, S. Jones, R. Hurst, and H. Callahan ParsonsL. Parsons , BoychukD. Boychuk JonesS. Jones HurstR. Hurst CallahanH. View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39897-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Sulfated polysaccharide's ability modulate the movement small...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Apr 2004ABNORMAL EXPRESSION OF MOLECULAR MARKERS FOR BLADDER IMPERMEABILITY AND DIFFERENTIATION IN THE UROTHELIUM PATIENTS WITH INTERSTITIAL CYSTITIS GENNADY SLOBODOV, MICHAEL FELONEY, CHRISTOPHER GRAN, KIMBERLY D. KYKER, ROBERT E. HURST, and DANIEL J. CULKIN SLOBODOVGENNADY SLOBODOV More articles by this author , FELONEYMICHAEL FELONEY GRANCHRISTOPHER GRAN KYKERKIMBERLY KYKER HURSTROBERT HURST CULKINDANIEL View All Author...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jun 2002A Comparison Multiple Urine Markers for Interstitial Cystitis DEBORAH R. ERICKSON, SHARON X. XIE, VEER P. BHAVANANDAN, MARCIA A. WHEELER, ROBERT E. HURST, LAWRENCE M. DEMERS, LESLIE KUSHNER, and SUSAN K. KEAY ERICKSONDEBORAH ERICKSON , XIESHARON XIE BHAVANANDANVEER BHAVANANDAN WHEELERMARCIA WHEELER HURSTROBERT HURST DEMERSLAWRENCE DEMERS KUSHNERLESLIE KUSHNER KEAYSUSAN View All Author...
No AccessJournal of UrologyInvestigative urology1 Feb 2008Abnormal Expression Differentiation Related Proteins and Proteoglycan Core in the Urothelium Patients With Interstitial Cystitisis companion ofFollowup Cystitis Responsive to Treatment Intravesical Bacillus Calmette-Guerin or Placebo Paul J. Hauser, Mikhail G. Dozmorov, Barbara L. Bane, Gennady Slobodov, Daniel Culkin, Robert E. Hurst HauserPaul Hauser Department Urology, College Medicine, Oklahoma University Health Sciences Center,...
No AccessJournal of Urology1 Aug 1987Functional and Structural Characteristics the Glycosaminoglycans Bladder Luminal Surface Robert E. Hurst, Steven W. Rhodes, Philip B. Adamson, C. Lowell Parsons, Johnny Roy HurstRobert Hurst , RhodesSteven Rhodes AdamsonPhilip Adamson ParsonsC. Parsons RoyJohnny View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)43180-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The...
Human prostate cancer LNCaP and PC-3 cell lines have been extensively used to study progression develop therapeutic agents. Although cells are generally assumed represent early late stages of cancer, respectively, there is limited information regarding gene expression patterns between these two its relationship cancer.Comprehensive analysis was performed. Total RNA isolated from cultured hybridized Illumina human BeadChips representing 24,526 transcripts. Bioinformatics applied identify line...
Most cancer patients die with metastatic disease, thus, good models that recapitulate the natural process of metastasis including a dormancy period micrometastatic cells would be beneficial in developing treatment strategies. Herein we report model balances time to complete experiments reasonable period, which can used better study progression. The basis for is 4T1 triple negative syngeneic breast without resection primary tumor. A cell titration from 500 15,000 GFP tagged implanted into fat...
Phenotypic biochemical markers of oncogenesis and differentiation were mapped in bladder biopsies to investigate changes that occur tumorigenesis identify for increased cancer risk. Touch preparations from biopsy specimens 30 patients obtained tumors, the adjacent epithelium, random distant epithelium. Markers, including DNA ploidy, epidermal growth factor receptor (EGFR), oncoproteins, quantified individual cells by using quantitative fluorescence image analysis. Cluster analysis revealed...
Bladder cancer has a 60%-70% recurrence rate most likely due to any residual tumour left behind after transurethral resection (TUR). Failure completely resect the can lead and progression into higher grade tumours with metastatic potential. We present here novel therapy treat superficial potential decrease recurrence. The is heat-based approach in which bladder specific single-walled carbon nanotubes (SWCNTs) are delivered intravesically at very low dose (0.1 mg SWCNT per kg body weight)...
Chemical modification of naturally derived glycosaminoglycans (GAGs) expands their potential utility for applications in soft tissue repair and regenerative medicine. Here we report the preparation a novel crosslinked chondroitin sulfate (~200 to 2000 kilodaltons) that is both soluble aqueous solution microfilterable. We refer these materials as “SuperGAGs.” One can further conjugate with diverse capture agents modify polymer properties add new capabilities. A representative material...
Background: Cancer screening with highly sensitive, specific biomarkers that reflect molecular phenotypic alterations is an attractive strategy for cancer control. We examined whether biomarker profiles could be used risk assessment and detection in a cohort of Chinese workers occupationally exposed to benzidine at bladder cancer. Methods: The consisted 1788 373 nonexposed workers, followed from 1991 through 1997. assayed urothelial cells voided urine samples DNA ploidy (expressed as the...
Curcumin, a potential chemopreventive agent, was found to inhibit cancer cells in S/G2M phases of the cell cycle, when radiation is more effective. The purpose current study investigate whether curcumin can sensitize squamous carcinoma (SCC) ionizing effects irradiation.Curcumin (3.5 microM) added for 48 hours an SCC line prior irradiation. Cell growth (counts) and colony-formation (colonogenic assay) were examined after radiation.Incubation with only (3.75 did not decrease number or ability...
No AccessJournal of Urology1 Jan 1993Urinary Glycosaminoglycan Excretion as a Laboratory Marker in the Diagnosis Interstitial Cystitisis companion ofReply by AuthorsEditorial Comment Robert E. Hurst, C. Lowell Parsons, Johnny B. Roy, and James L. Young HurstRobert Hurst More articles this author , ParsonsC. Parsons RoyJohnny Roy YoungJames View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)35990-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...
To better understand how heparin structure affects its activity the relationships between functional domains for inhibitor binding and charge density were investigated to determine these affect heparin-mediated thrombin inhibition by two different heparin-dependent protease inhibitors, antithrombin (AT) cofactor II (HC II). A series of heparins, fractionated systematically density, was further on agarose isolate more homogeneous subfractions that either inactive or highly active with respect...
Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR1C enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in localized advanced prostate adenocarcinoma, associated with cancer (PCa) aggressiveness. Here we propose a novel pathological function tumor angiogenesis its potential role promoting PCa progression.To recapitulate elevated expression cancerous PC-3 cell line was stably transfected an...
The definition of interstitial cystitis (IC) has evolved over the years from being a well-defined entity characterized by diagnostic lesion (Hunner's ulcer) in urothelium to clinical diagnosis exclusion (painful bladder syndrome (PBS). Although etiology is unknown, central theme been an association with increased permeability bladder. This article reviews evidence for important symptoms IC/PBS and treating disorder. Recent work showing cross-communication among visceral organs also reviewed...
Background. The detection of potentially highly curable low-grade bladder cancers by noninvasive techniques remains an unsolved problem. Conventional cytology detects such tumors with 50% sensitivity, and addition DNA measurements to only improves sensitivity incrementally. Tumor-associated antigens offer additional diagnostic marker. Methods. In this study, the M344 antibody against a tumor-associated antigen expressed mainly tumor cells was tested for its specificity, alone in combination...
No AccessJournal of Urology1 Nov 1994Identification Proteoglycans Present at High Density on Bovine and Human Bladder Luminal Surface Robert E. Hurst, Zebrowski HurstRobert Hurst , ZebrowskiRobert View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)32495-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The proteoglycans the bladder luminal surface that have been implicated in producing impermeability...
The pathogenesis of interstitial cystitis currently is unknown. A possible etiology that the transitional epithelium defective, leading to molecular leaks initiate disease complex. An important surface defense mechanism glycosaminoglycans or polysaccharides line bladder and act as a nonspecific antiadherence factor blocking access bacteria, microcrystals, proteins ions underlying cells. We examined excretion urinary macromolecular uronic acid in normal individuals those with cystitis. total...