A5017916044- HIV Research and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Acute Myeloid Leukemia Research
- HIV/AIDS drug development and treatment
- Retinoids in leukemia and cellular processes
- HIV/AIDS Research and Interventions
- Neuroscience and Neuropharmacology Research
- Erythrocyte Function and Pathophysiology
- Complement system in diseases
- T-cell and B-cell Immunology
- Biochemical Analysis and Sensing Techniques
- Platelet Disorders and Treatments
- vaccines and immunoinformatics approaches
- CNS Lymphoma Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Sphingolipid Metabolism and Signaling
- PI3K/AKT/mTOR signaling in cancer
- Ion Transport and Channel Regulation
- Circadian rhythm and melatonin
- Nicotinic Acetylcholine Receptors Study
- Physiological and biochemical adaptations
- Kruppel-like factors research
- Calcium signaling and nucleotide metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Cutaneous Melanoma Detection and Management
University of Auckland
2014-2024
Pennsylvania State University
2023
University of Notre Dame
2016
Jackson State University
2013
University of Mississippi Medical Center
2010-2012
Jackson Memorial Hospital
2010-2012
University of KwaZulu-Natal
2010-2011
State Street (United States)
2010
University of Pennsylvania
2007
Marine and freshwater zooplankton exhibit daily rhythmic patterns of behavior physiology which may be regulated directly by the light:dark (LD) cycle and/or a molecular circadian clock. One best-studied taxa, crustacean Daphnia, has 24 h diel vertical migration (DVM) whereby organism travels up down through water column daily. DVM plays critical role in resource tracking behavioral avoidance predators damaging ultraviolet radiation. However, there is little information at transcriptional...
Objectives: This study aimed to compile bioinformatic and experimental information for JAK2 missense variants previously reported in myeloproliferative neoplasms (MPN) determine if germline JAK2-I724T, recently found be common New Zealand Polynesians, associates with MPN.
Previous whole-exome sequencing has demonstrated that melanoma tumours harbour mutations in the GRIN2A gene. encodes regulatory GluN2A subunit of glutamate-gated N-methyl-D-aspartate receptor (NMDAR), involvement which remains undefined. Here, we sequenced coding exons 19 low-passage cell lines derived from patients with metastatic melanoma. Potential mutation impact was evaluated silico, including within crystal structure, and clinical correlations were sought. We found tumours, four (21%)...
Drug resistance poses a significant challenge for the successful application of highly active antiretroviral therapy (HAART) globally. Furthermore, emergence HIV-1 isolates that preferentially use CXCR4 as coreceptor cell entry, either consequence natural viral evolution or HAART use, may compromise efficacy CCR5 antagonists alternative antiviral therapy.We sequenced pol gene viruses from 45 individuals failing at least 6 months in Durban, South Africa, to determine prevalence and patterns...
HIV-1 drug resistance monitoring in resource-poor settings is crucial due to limited alternatives. Recent reports of the increased prevalence CXCR4 usage subtype C infections may have implications for CCR5 antagonists therapy. We investigated mutations and coreceptor utilization viruses from C-infected children. Fifty-one children with virological failure during highly active antiretroviral therapy (HAART) 43 HAART-naive were recruited. Drug genotyping assessment by phenotypic genotypic...
GluN1 is a mandatory component of N-methyl-D-aspartate receptors (NMDARs) best known for their roles in the brain, but with increasing evidence relevance peripheral tissues, including platelets. Certain anti-GluN1 antibodies reduce brain infarcts rodent models ischaemic stroke. There also that human autoantibodies neuronal damage stroke patients, underlying mechanism unclear. This study investigated whether anti-GluN1-mediated neuroprotection involves inhibition platelet function. Four...
HIV-1 CRF02_AG and subtype G (HIV-1G) account for most HIV infections in Nigeria, but their evolutionary trends have not been well documented. To better elucidate the dynamics of epidemic Nigeria we characterised gag env genes North-Central Nigerian isolates from pregnant women. Of 28 samples sequenced both genes, predominant clades were (39%) HIV-1G (32%). Higher predicted proportion CXCR4-tropic (X4) was noted compared to (p = 0.007, Fisher's exact test). Phylogenetic Bayesian analysis...
Abstract Background HIV-1 envelope diversity remains a significant challenge for the development of an efficacious vaccine. The evolutionary forces that shape are incompletely understood. subtype C in particular shows differences and unique characteristics compared to its B counterpart. Here we applied single genome sequencing strategy plasma derived virus from cohort therapy naïve chronically infected individuals order study diversity, divergence patterns across entire gp160 4 slow...
Abstract The release of calcium ions (Ca2+) from the endoplasmic reticulum (ER) and related store-operated entry (SOCE) regulate maturation normal megakaryocytes. N-methyl-D-aspartate (NMDA) receptor (NMDAR) provides an additional mechanism for Ca2+ influx in megakaryocytic cells, but its role remains unclear. We created a model NMDAR hypofunction Meg-01 cells using CRISPR-Cas9 mediated knockout GRIN1 gene, which encodes obligate, GluN1 subunit NMDAR. found that compared with unmodified...
N-methyl-d-aspartate receptors (NMDARs) contribute calcium influx in megakaryocytic cells but their roles remain unclear; both pro- and anti-differentiating effects have been shown different contexts.The aim of this study was to clarify NMDAR contribution differentiation normal leukemic cells.Meg-01, Set-2, K-562 cell lines were differentiated using phorbol-12-myristate-13-acetate (PMA, 10 nmol L-1) or valproic acid (VPA, 500 μmol L-1). Normal megakaryocytes grown from mouse marrow-derived...
Memorability denotes a stimulus-intrinsic property that results in stimuli being more likely to be remembered or forgotten. The effect is consistent across observers and can measured various such as faces scene images. Long-term memory (LTM) paradigms have been used measure memorability with studies demonstrating long-term effects via incidental intentional encoding mechanisms. current study expands the understanding of examines whether modulates ability unexpectedly report an image at short...
Current guidelines recommend that a rapid test be used to assist diagnosis of acute promyelocytic leukaemia (APL), but the choice an assay is discretionary. PML immunofluorescence (PML IF) identifies microparticulate pattern protein localisation, highly specific for APL. The aim this study was evaluate clinical utility IF in real-life setting based on retrospective records review all patients who had performed our centre between 2000 and 2017. Final analysis included 151 patients, 70 whom...
Ethnic differences in haematologic malignancies remain poorly elucidated, hence research this area is important.This was a retrospective study into potential ethnic disparity the presentation and outcomes of acute promyelocytic leukaemia (APL) between New Zealand (NZ) Polynesian European patients. Data were analysed for patients treated at Auckland City Hospital (ACH; n = 55) recorded Cancer Registry (NZCR; 173), both period 2000–2017.We found that ACH presented younger age than (P 0.005),...
Ischaemic brain damage induces autoimmune responses, including the production of autoantibodies with potential neuroprotective effects. Platelets share unexplained similarities neurons, and formation anti-platelet antibodies has been documented in neurological disorders. The aim this study was to investigate presence peripheral blood patients after ischaemic stroke determine any clinical correlations. Using a flow cytometry-based platelet immunofluorescence method, we detected...