A5029426622- Gut microbiota and health
- Probiotics and Fermented Foods
- Genomics and Phylogenetic Studies
- Nutrition, Genetics, and Disease
- Carbon Nanotubes in Composites
- Cystic Fibrosis Research Advances
- Mechanical and Optical Resonators
- Identification and Quantification in Food
- Bacteriophages and microbial interactions
- Tryptophan and brain disorders
- Tracheal and airway disorders
- Diet and metabolism studies
- Nutritional Studies and Diet
- Biosensors and Analytical Detection
- Microbial Community Ecology and Physiology
- Protein Hydrolysis and Bioactive Peptides
- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Meat and Animal Product Quality
- Epigenetics and DNA Methylation
- Fermentation and Sensory Analysis
- Pediatric health and respiratory diseases
- Cholesterol and Lipid Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Spectroscopy Techniques in Biomedical and Chemical Research
Trinity College Dublin
2024-2025
Le Bonheur Children's Hospital
2025
University of Tennessee Health Science Center
2025
St. James's Hospital
2025
APC Microbiome Institute
2016-2024
University College Cork
2016-2024
Harvard University
2005-2024
Teagasc - The Irish Agriculture and Food Development Authority
2016-2024
Harvard University Press
2024
Broad Institute
2023-2024
Kefir is a putatively health-promoting dairy beverage that produced when kefir grain, consisting of consortium microorganisms, added to milk initiate natural fermentation. Here, detailed analysis was carried out determine how the microbial population, gene content, and flavor three kefirs from distinct geographic locations change over course 24-h fermentations. Metagenomic sequencing revealed Lactobacillus kefiranofaciens dominant bacterial species in during early stages fermentations but...
Fermented foods are regaining popularity worldwide due in part to a greater appreciation of the health benefits these and associated microorganisms. Here, we use state-of-the-art approaches explore microbiomes 58 foods, identifying factors that drive microbial composition potential functional with populations. Food type, i.e., dairy-, sugar-, or brine-type fermented was primary driver composition, dairy found have lowest diversity and, notably, promoting attributes were more common than...
Abstract Background Mounting evidence suggests a role for the gut microbiota in modulating brain physiology and behaviour, through bi-directional communication, along gut-brain axis. As such, represents potential therapeutic target influencing centrally mediated events host behaviour. It is thus notable that fermented milk beverage kefir has recently been shown to modulate composition of mice. unclear whether kefirs have differential effects on microbiota-gut-brain axis they can behaviour...
ABSTRACT The rapid detection of pathogenic strains in food products is essential for the prevention disease outbreaks. It has already been demonstrated that whole-metagenome shotgun sequencing can be used to detect pathogens but, until recently, strain-level relied on assembly, which a computationally demanding process. Here we three short-read-alignment-based methods, i.e., MetaMLST, PanPhlAn, and StrainPhlAn, could accurately rapidly identify spinach metagenomes had intentionally spiked...
Fermented foods, in particular, surface-ripened cheese, represent a model to explain the metabolic interactions which regulate microbial succession complex environments. This study explains role of individual species heterogeneous environment, i.e., exterior cheese. Through whole-metagenome shotgun sequencing, it was possible investigate potential resident microorganisms and show how variations populations influence important aspects cheese ripening, especially flavor development. Overall,...
The use of shotgun metagenomics to analyse low-complexity microbial communities in foods has the potential be considerable fundamental and applied value. However, there is currently no consensus with respect choice species classification tool, platform, or sequencing depth. Here, we benchmarked performances three high-throughput short-read platforms, Illumina MiSeq, NextSeq 500, Ion Proton, for food microbiota. Briefly, sequenced six kefir DNA samples a mock community sample, latter...
Fungal β-glucans are major drivers of trained immunity which increases long-term protection against secondary infections. Heterogeneity in β-glucan source, structure, and solubility alters interaction with the phagocytic receptor Dectin-1 could impact strategies to improve humans. Using a panel diverse β-glucans, we describe ability specific yeast-derived whole-glucan particle (WGP) reprogram metabolism thereby drive human monocyte-derived macrophages
Autism spectrum disorder (ASD) is one of the most severe developmental disorders, affecting on average 1 in 150 children worldwide. There a great need for more effective strategies to improve quality life ASD subjects. The gut microbiome has emerged as potential therapeutic target ASD. A novel modulator microbiome, traditionally fermented milk drink kefir, recently been shown modulate microbiota and decrease repetitive behaviour, hallmarks ASD, mice. As such, we hypothesized that kefir could...
A comprehensive metagenomics-based investigation of the microorganisms present within milk kefir communities from across globe was carried out with a view to defining pan-metagenome, including details relating core and non-core components. Milk samples, generated by inoculating full fat, pasteurized cow's 64 grains sourced 25 different countries, were analyzed. We identified features, consistent pattern domination representatives species Lactobacillus helveticus or sub-species...
Background: From October 2022 to June 2023, there was a 4-fold increase in pediatric invasive group A streptococcus cases (iGAS) the Republic of Ireland. This project aimed better understand clinical characteristics and disease course iGAS children Ireland inform Public Health interventions messaging for carers, clinicians public. Methods: All notified under 16 years from 2023 inclusive were collated. case review every death hospitalization performed auspices National Incident Management...
Tunable Raman spectroscopy is used to measure the optical transition energies ${E}_{ii}$ of individual single wall carbon nanotubes. observed shift down in energy by as much 50 meV, from $\ensuremath{-}160$ 300 \ifmmode^\circ\else\textdegree\fi{}C, contrast with previous measurements performed on nanotubes alternate environments, which show upshifts and downshifts temperature. We determine that electron-phonon coupling explains our experimental observations suspended air, neglecting thermal...
Abstract Cystic Fibrosis (CF) and its treatment result in an altered gut microbiota composition compared to non-CF controls. However, the impact of this on functionality has not been extensively characterised. Our aim was conduct a proof-of-principle study investigate if measurable changes occur adult CF patients Metagenomic DNA extracted from faecal samples six controls shotgun metagenomic sequencing performed MiSeq platform. Metabolomic analysis using gas chromatography-mass spectrometry...