A5018730000- Graphene and Nanomaterials Applications
- Carbon Nanotubes in Composites
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- Graphene research and applications
- Nanoparticles: synthesis and applications
- Advanced Nanomaterials in Catalysis
- Molecular Junctions and Nanostructures
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- Synthesis and Biological Evaluation
- Synthetic Organic Chemistry Methods
- Photoacoustic and Ultrasonic Imaging
- Luminescence and Fluorescent Materials
- Neuroscience and Neural Engineering
- Nutritional Studies and Diet
- Anesthesia and Neurotoxicity Research
- Fullerene Chemistry and Applications
- Nanotechnology research and applications
- Chemical Synthesis and Analysis
- RNA Interference and Gene Delivery
- Radiation Therapy and Dosimetry
- Asymmetric Synthesis and Catalysis
- Laser-Ablation Synthesis of Nanoparticles
Centre National de la Recherche Scientifique
2016-2025
Université de Strasbourg
2016-2025
Institut de Biologie Moléculaire et Cellulaire
2012-2024
Immunologie, Immunopathologie et Chimie Thérapeutique
2013-2024
University of Puerto Rico at Carolina
2020
Hôpitaux Universitaires de Strasbourg
2019
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2008-2017
University of York
2007-2009
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2003-2007
Institut de Biologie et Technologies
2007
Understanding human health risk associated with the rapidly emerging graphene‐based nanomaterials represents a great challenge because of diversity applications and wide range possible ways exposure to this type materials. Herein, biodegradation graphene oxide (GO) sheets is reported by using myeloperoxidase (hMPO) derived from neutrophils in presence low concentration hydrogen peroxide. The degradation capability enzyme on three different GO samples containing degree oxidation their...
In this study we compare the biodegradation of both single-walled (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) using two different oxidative conditions. particular, demonstrate that oxidized are highly degraded, although not to completeness when treated with horseradish peroxidase (HRP) in presence hydrogen peroxide.
Graphene oxide (GO) is an attractive nanomaterial for many applications. Controlling the functionalization of GO essential design graphene-based conjugates with novel properties. But, chemical composition has not been fully elucidated yet. Due to high reactivity oxygenated moieties, mainly epoxy, hydroxyl and carboxyl groups, several derivatization reactions may occur concomitantly. The amine derivatives exploited in literature conjugates, through amidation. However, this study we...
Despite numerous applications, the cellular-clearance mechanism of multiwalled carbon nanotubes (MWCNTs) has not been clearly established yet. Previous in vitro studies showed ability oxidative enzymes to induce nanotube degradation. Interestingly, these have common capacity produce reactive oxygen species (ROS). Here, we combined material and life science approaches for revealing an intracellular way taken by macrophages degrade nanotubes. We report situ monitoring ROS-mediated MWCNT...
Ultrasonography is a fundamental diagnostic imaging tool in everyday clinical practice. Here, we are unique describing the use of functionalized multiwalled carbon nanotubes (MWCNTs) as hyperechogenic material, suggesting their potential application ultrasound contrast agents. Initially, carried out thorough investigation to assess echogenic property vitro. We demonstrated long-lasting properties. also showed that signal MWCNTs higher than graphene oxide, pristine MWCNTs, and single-walled...
Abstract Understanding the biomolecular interactions between graphene and human immune cells is a prerequisite for its utilization as diagnostic or therapeutic tool. To characterize complex cells, we propose an integrative analytical pipeline encompassing evaluation of molecular cellular parameters. Herein, use single-cell mass cytometry to dissect effects oxide (GO) GO functionalized with amino groups (GONH 2 ) on 15 cell populations, interrogating 30 markers at level. Next, integration...
The design of graphene-based materials for biomedical purposes is great interest. Graphene oxide (GO) sheets represent the most widespread type graphene in biological investigations. In this work, thin GO were synthesized and further chemically functionalized with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), a stable radiometal chelating agent, by an epoxide opening reaction. We report tissue distribution labeled radioactive indium (
Nanocomposites combining multiple functionalities in one single nano-object hold great promise for biomedical applications. In this work, carbon nanotubes (CNTs) were filled with ferrite nanoparticles (NPs) to develop the magnetic manipulation of and their theranostic The challenges both filling CNTs a high amount NPs functionalization form biocompatible water suspensions. We propose here process using as nanoreactors high-yield situ growth into inner cavity. At first, formed inside by...
Graphene oxide (GO) is one of the most studied nanomaterials in many fields, including biomedical field. Most developed for drug delivery and phototherapies are based on noncovalent approaches that lead to an unspecific release physisorbed molecules complex biological environments. Therefore, preparing covalently functionalized GO using straightforward versatile methods highly valuable. Phototherapies, photothermal therapy (PTT) photodynamic (PDT), have shown great potential as effective...
A mild and efficient method for the functionalization of SWNTs by cycloaddition azomethine ylides derived from trialkylamine-N-oxides is described. Selective reaction semiconducting carbon nanotubes was achieved preorganizing starting N-oxides on nanotube surface prior to generating reactive ylides. Separation met-SWNTs functionalized sem-SWNTs successfully accomplished inducing solubilization in presence lignoceric acid.
As first described in the 1980s, core food intake model allows a precise assessment of dietary nutrient and exposure to contaminants insofar as it reflects eating habits target population covers most important foods terms consumption, selected contaminant contribution. This has been used set up sampling strategy second French Total Diet Study (TDS) with aim obtaining realistic panorama intakes for whole population, useful quantitative risk assessment. Data on consumption trends from...
Hexagonal boron nitride (hBN) nanosheets are emerging as promising 2D materials for different types of applications. However, biodegradation hBN is poorly explored owing to their high chemical inertness and strong oxidation resistance. The assessment oxidation/biodegradation important in developing biomedical tools. Herein, we report the first study on biodegradability comparing enzymatic catalysis two peroxidases, horseradish peroxidase (HRP) human myeloperoxidase (MPO), with photo-Fenton...
Understanding how two-dimensional (2D) nanomaterials interact with the biological milieu is fundamental for their development toward biomedical applications. When thin, individualized graphene oxide (GO) sheets were administered intravenously in mice, extensive urinary excretion was observed, indicating rapid transit across glomerular filtration barrier (GFB). A detailed analysis of kidney function, histopathology, and ultrastructure performed, along vitro responses two highly specialized...
Tumor stiffening, stemming from aberrant production and organization of extracellular matrix (ECM), has been considered a predictive marker tumor malignancy, non-invasively assessed by ultrasound shear wave elastography (SWE). Being more than passive marker, stiffening restricts the delivery diagnostic therapeutic agents to per se could modulate cellular mechano-signaling, tissue inflammation progression. Current strategies modify are based on ECM-targeting chemical but also showed...
Abstract In the context of designing novel amino acid nanostructures, capacity tyrosine alone to form well‐ordered structures under different conditions was explored. It observed that Tyr can self‐assemble into well‐defined morphologies when deposited onto surfaces for transmission electron microscopy, atomic force and scanning microscopy. The influence various parameters modulate self‐assembly process, including concentration acid, aging time, solvent, studied. Different supramolecular...