A5025308944- Gut microbiota and health
- Reproductive tract infections research
- Genetic Associations and Epidemiology
- Genomics and Rare Diseases
- Legionella and Acanthamoeba research
- Inflammatory Bowel Disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Reproductive System and Pregnancy
- Clostridium difficile and Clostridium perfringens research
- Pregnancy and preeclampsia studies
- Vibrio bacteria research studies
- Vitamin D Research Studies
- Preterm Birth and Chorioamnionitis
- Oral microbiology and periodontitis research
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Antibiotic Resistance in Bacteria
- Microscopic Colitis
- Infant Nutrition and Health
- Heme Oxygenase-1 and Carbon Monoxide
- Celiac Disease Research and Management
- Immune Response and Inflammation
- Diet and metabolism studies
- Salivary Gland Disorders and Functions
- Vitamin C and Antioxidants Research
Qatar Airways (Qatar)
2015-2024
Hamad bin Khalifa University
2022
Sidra Medical and Research Center
2015-2020
National Institute of Allergy and Infectious Diseases
2013-2015
National Institutes of Health
2010-2015
University of Louisville
2008-2013
Molina Center for Energy and the Environment
2008
University of Louisville Hospital
2008
American University of Beirut
2005
Abstract Vitamin D deficiency affects approximately 80% of individuals in some countries and has been linked with gut dysbiosis inflammation. While the benefits vitamin supplementation on microbiota have studied patients chronic diseases, its effects otherwise healthy is unclear. Moreover, whether can explain marked inter-individual variation responsiveness to unknown. Here, we administered 80 D-deficient women, measuring serum 25(OH) levels blood characterizing their pre- post- using 16S...
The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification accurate biomarkers clinical outcome. In this cohort study, we performed comprehensive genomic analyses on fresh-frozen samples from 348 patients affected by primary colon cancer, encompassing RNA, whole-exome, deep T cell receptor and 16S bacterial rRNA gene sequencing tumor matched healthy tissue, complemented whole-genome for further microbiome characterization. A type 1 helper cell,...
Owing to limited drug testing possibilities in pregnant population, the development of computational algorithms is crucial predict fate drugs placental barrier; it could serve as an alternative animal testing. The ability a molecule effectively cross barrier and reach fetus determines drug's toxicological effects on fetus. In this regard, our study aims permeability molecules across barrier. Based publicly available datasets, several machine learning models are comprehensively analysed...
The ability of Legionella pneumophila to proliferate within various protozoa in the aquatic environment and macrophages indicates a remarkable evolution microbial exploitation evolutionarily conserved eukaryotic processes. Ankyrin B (AnkB) L. is non-canonical F-box-containing protein, only known Dot/Icm-translocated effector essential for intra-vacuolar proliferation both protozoan hosts. We show that F-box domain AnkB 9L10P residues are intracellular bacterial rapid acquisition...
Chlamydia trachomatis attachment to cells induces the secretion of elementary body–associated protein TARP (Translocated Actin Recruiting Protein). crosses plasma membrane where it is immediately phosphorylated at tyrosine residues by unknown host kinases. The Rac GTPase also activated, resulting in WAVE2 and Arp2/3-dependent recruitment actin sites chlamydia attachment. We show that participates directly chlamydial invasion activating Rac-dependent signaling cascade recruit actin. functions...
The Dot/Icm type IV secretion system of Legionella pneumophila translocates numerous bacterial effectors into the host cell and is essential for proliferation within macrophages protozoa. We have recently shown that L. strain AA100/130b harbours 11 genes encoding eukaryotic-like ankyrin (Ank) proteins, a family proteins involved in various eukaryotic cellular processes. In contrast to most Dot/Icm-exported substrates, which little or no detectable role intracellular proliferation, mutation...
Genome sequencing of large biobanks from under-represented ancestries provides a valuable resource for the interrogation Mendelian disease burden at world population level, complementing small-scale familial studies. Here, we interrogate 6045 whole genomes Qatar-a Middle Eastern with high consanguinity and understudied mutational burden-enrolled national Biobank phenotyped 58 clinically-relevant quantitative traits. We examine curated set 2648 genes 20 panels, annotating known novel...
Summary Legionella pneumophila is a ubiquitous organism in the aquatic environment where it capable of invasion and intracellular proliferation within various protozoan species also causing pneumonia humans. In silico analysis showed that three sequenced L. genomes each contained common multigene family 11 ankyrin ( ank ) genes encoding proteins with ∼30–35 amino acid tandem Ankyrin repeats are involved protein–protein interactions eukaryotic cells. To examine whether tropism hosts, we have...
Abstract Background The role of the human microbiome in health and disease has been studied various body sites. However, compared to gut microbiome, where most research focus is, salivary still bears a vast amount information that needs be revealed. This study aims characterize composition Qatari population, explore specific microbial signatures can associated with lifestyles different oral conditions. Materials methods We characterized 997 adults using high-throughput sequencing V1–V3...
Abstract Clinical laboratory tests play a pivotal role in medical decision making, but little is known about their genetic variability between populations. We report genome-wide association study with 45 clinically relevant traits from the population of Qatar using whole genome sequencing approach discovery set 6218 individuals and replication 7768 subjects. Trait heritability more similar Qatari European populations ( r = 0.81) than Africans 0.44). identify 281 distinct...
Preterm birth (PTB) is the most common cause of neonatal morbidity and mortality worldwide. Approximately half PTBs linked with microbial etiologies, including pathologic changes to vaginal microbiota, which vary according ethnicity. Globally more than 50% occur in Asia, but studies microbiome its association pregnancy outcomes Asian women are lacking. This study aimed longitudinally analyzed cytokine environment 18 Karen Burman pregnant who delivered preterm 36 matched controls delivering...