A5102881759- Gut microbiota and health
- Reproductive tract infections research
- Vitamin D Research Studies
- Celiac Disease Research and Management
- Preterm Birth and Chorioamnionitis
- Pelvic floor disorders treatments
- Vitamin C and Antioxidants Research
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Reproductive System and Pregnancy
- Clostridium difficile and Clostridium perfringens research
- Alzheimer's disease research and treatments
- Gynecological conditions and treatments
- Biochemical Analysis and Sensing Techniques
- Oral microbiology and periodontitis research
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Biosensors and Analytical Detection
- Glaucoma and retinal disorders
- Digestive system and related health
- Breastfeeding Practices and Influences
- Menstrual Health and Disorders
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Health Systems, Economic Evaluations, Quality of Life
All India Institute of Medical Sciences
2020-2025
All India Institute of Medical Sciences Raipur
2025
Bristol-Myers Squibb (United States)
2016-2024
Manipal Academy of Higher Education
2024
Kasturba Medical College, Manipal
2024
Hamad bin Khalifa University
2021-2023
Qatar Foundation
2021-2023
Baba Mastnath University
2023
University of Helsinki
2020-2022
Motilal Nehru National Institute of Technology
2022
Abstract Vitamin D deficiency affects approximately 80% of individuals in some countries and has been linked with gut dysbiosis inflammation. While the benefits vitamin supplementation on microbiota have studied patients chronic diseases, its effects otherwise healthy is unclear. Moreover, whether can explain marked inter-individual variation responsiveness to unknown. Here, we administered 80 D-deficient women, measuring serum 25(OH) levels blood characterizing their pre- post- using 16S...
The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification accurate biomarkers clinical outcome. In this cohort study, we performed comprehensive genomic analyses on fresh-frozen samples from 348 patients affected by primary colon cancer, encompassing RNA, whole-exome, deep T cell receptor and 16S bacterial rRNA gene sequencing tumor matched healthy tissue, complemented whole-genome for further microbiome characterization. A type 1 helper cell,...
Abstract Background The role of the human microbiome in health and disease has been studied various body sites. However, compared to gut microbiome, where most research focus is, salivary still bears a vast amount information that needs be revealed. This study aims characterize composition Qatari population, explore specific microbial signatures can associated with lifestyles different oral conditions. Materials methods We characterized 997 adults using high-throughput sequencing V1–V3...
Preterm birth (PTB) is the most common cause of neonatal morbidity and mortality worldwide. Approximately half PTBs linked with microbial etiologies, including pathologic changes to vaginal microbiota, which vary according ethnicity. Globally more than 50% occur in Asia, but studies microbiome its association pregnancy outcomes Asian women are lacking. This study aimed longitudinally analyzed cytokine environment 18 Karen Burman pregnant who delivered preterm 36 matched controls delivering...
: Coronavirus disease 2019 (COVID-19) has so far affected over 41 million people globally. The limited supply of real-time reverse transcription-polymerase chain reaction (rRT-PCR) kits and reagents made meeting the rising demand for increased testing incompetent, worldwide. A highly sensitive specific antigen-based rapid diagnostic test (RDT) is need hour. objective this study was to evaluate performance a chromatographic immunoassay-based (index test) compared with clinical reference...
Background. The composition of the microbiome in human body sites plays an important role health. vaginal environment is colonized by several species bacteria that have a major influence on reproductive advancement sequencing technologies has made assessment microbiota possible through microbial DNA extraction and sequencing. Therefore, it paramount importance to select sensitive reproducible method, facilitates isolation with sufficient quantity purity, from living environment. Here, we...
For years, the placenta was believed to be sterile, but recent studies reveal it hosts a unique microbiome. Despite these findings, significant questions remain about origins of placental microbiome and its effects on pregnancy fetal health. Some suggest may originate from vaginal tract, while others indicate that oral bacteria can enter maternal bloodstream seed placenta. However, research analyzing vaginal, oral, microbiomes within same cohort is lacking. Additionally, it's unclear whether...
Introduction:The presentation of liver disease in pregnancy is varied and ranges from asymptomatic elevation transaminases to fatal failure which causes significant morbidity even mortality. Aims Objectives:To analyse the association clinical biochemical parameters affecting maternal fetal outcome acute & injury pregnancy. Materials Methods-It was a prospective observational study conducted over one year involving 135 pregnant patients between19- 40-year-old with raised enzymes or...
Antimicrobial resistance (AMR) poses a global health threat, emphasizing the need for Point Prevalence Surveys (PPS) to understand antibiotic use and resistance. This study assesses patterns in tertiary care hospitals across India inform AMR interventions. cross-sectional survey was conducted over two weeks between May August 2023 eight Indian hospitals. The comprised parts: ward form, which captured details (name, specialty, bed count, use), patient documented demographics, antimicrobial...
Breast milk (BM) provides complete nutrition for infants the first six months of life and is essential development newborn's immature immune digestive systems. While BM was conventionally believed to be sterile, recent advanced high throughput technologies have unveiled presence diverse microbial communities in BM. These insights into microbiota mainly originated from uncomplicated pregnancies, possibly not reflecting circumstances mothers with pregnancy complications like preterm birth...
The binding of vincristine with DNA has been investigated using Fourier transform infrared spectroscopy. Various changes in the double helical structure after addition have examined. It is evident from results that vincristine-DNA interaction occurs through guanine and cytosine base pairs. External phosphate backbone also observed. Vincristine perturbs band at 1714 cm(-1), 1488 vibrations 1225 1086 cm(-1). UV-visible spectra complex show hypochromic bathochromic shifts, indicating...
Background. Vitamin D deficiency represents a major healthcare problem. status is influenced by genetic and environmental determinants. Several observational studies have evaluated the association of single-nucleotide polymorphisms (SNPs) in vitamin D-related genes levels. Nevertheless, little known about role these SNPs response to supplementation. We conducted an interventional study define between supplementation 100 self-reported healthy women Arab ancestry for majority. Methods. A total...
Coeliac disease (CD) and Type 1 diabetes mellitus (T1DM) are immune-mediated diseases. Emerging evidence suggests that dysbiosis in the gut microbiome plays a role pathogenesis of both diseases may also be associated with development neuropathy. The primary goal this cross-sectional pilot study was to identify whether there distinct microbiota alterations children CD (n = 19), T1DM 18) 9) compared healthy controls 12). Our second explore relationship between neuropathy (corneal nerve fiber...
Vitamin D inadequacy appears to be on the rise globally, and it has been linked an increased risk of osteoporosis, as well metabolic, cardiovascular, autoimmune diseases. concentrations are partially determined by genetic factors. Specific single nucleotide polymorphisms (SNPs) in genes involved vitamin transport, metabolism, or binding have found associated with its serum concentration, these SNPs differ among ethnicities. also suggested a regulator gut microbiota deficiency possible cause...