A5003969156- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Intraocular Surgery and Lenses
- Nosocomial Infections in ICU
- Vibrio bacteria research studies
- Surgical site infection prevention
- Bacterial Identification and Susceptibility Testing
- Traumatic Ocular and Foreign Body Injuries
- Trauma Management and Diagnosis
- Cardiac, Anesthesia and Surgical Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Connexins and lens biology
- Glaucoma and retinal disorders
- Trauma and Emergency Care Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Immune Response and Inflammation
- Infections and bacterial resistance
- Patient Satisfaction in Healthcare
- Ocular Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- Pleural and Pulmonary Diseases
- Urinary Tract Infections Management
- Tuberculosis Research and Epidemiology
- Ophthalmology and Visual Impairment Studies
- Genomics and Phylogenetic Studies
All India Institute of Medical Sciences
2015-2024
Post Graduate Institute of Medical Education and Research
2019-2022
Lok Nayak Jai Prakash Narayan Hospital
2019-2021
All India Institute of Medical Sciences Bhopal
2020
Christie's
2020
All India Institute of Medical Sciences Raipur
2020
University of Delhi
2011
BackgroundHealth-care-associated infections (HAIs) cause significant morbidity and mortality globally, including in low-income middle-income countries (LMICs). Networks of hospitals implementing standardised HAI surveillance can provide valuable data on burden, identify monitor prevention gaps. Hospitals many LMICs use case definitions developed for higher-resourced settings, which require human resources laboratory imaging tests that are often not available.MethodsA network 26...
Recently, in India, there has been a shift from NDM to OXA48-like carbapenemases. OXA-181 and OXA-232 are the frequently produced variants of carbapenemases also known be carried on transposons such as Tn1999, Tn1999.2 it is associated with IS1R Tn1999. In no previous reports studying association mobile genetic elements (MGEs) The present study was aimed at determining backbone determine role MGEs its transfer investigate Inc plasmid type carrying blaOXA48-like.A total 49 carbapenem...
: Coronavirus disease 2019 (COVID-19) has so far affected over 41 million people globally. The limited supply of real-time reverse transcription-polymerase chain reaction (rRT-PCR) kits and reagents made meeting the rising demand for increased testing incompetent, worldwide. A highly sensitive specific antigen-based rapid diagnostic test (RDT) is need hour. objective this study was to evaluate performance a chromatographic immunoassay-based (index test) compared with clinical reference...
Purpose. Resistant Gram-negative bacterial (GNB) infections, apart from tremendously escalating the cost of treatment, are a cause for substantial morbidity and mortality among hospitalized patients. Such bacteria rapidly acquiring resistance to many antimicrobial agents, especially beta-lactams which most frequently prescribed antimicrobials in hospital community patient care settings, now also colistin; last-line drug treat infections with such bacteria. The greatest threat treatment is...
To investigate antimicrobial resistance mechanisms in a cluster of colistin-resistant Klebsiella pneumoniae.Antimicrobial susceptibility was tested by disk diffusion and broth microdilution. Whole-genome sequencing genome analysis were performed.The eight K. pneumoniae isolates belonged to three different clones (ST11, 14 231). The eptA arnT genes from lipid modification pathway had novel (R157S Q319R eptA) rare mutations (V39L, R152H, S260L A279G eptA). Several substitutions also identified...
Background: Preclinical studies have reported significant changes in the gut microbiome after traumatic brain injury (TBI). We hypothesized that TBI induces growth of Proteobacteria human gut. Our primary outcome was to study profile fecal and secondary identify colonization with colistin-resistant multidrug-resistant pathogens. Methods: Consecutive patients moderate-severe admitted neurotrauma-intensive care unit within 48 hours were enrolled into this observational study. Samples from...
Abstract BACKGROUND: The purpose of the study was to determine prevalence and characterize resistance profiles Escherichia coli isolated from various clinical specimens by phenotypic genotypic methods. MATERIALS AND METHODS: A total 196 consecutive, nonduplicate strains clinically significant E. were included in study. Identification antimicrobial susceptibility testing performed using Vitek-2 system (Biomerieux, France). Phenotypic detection extended spectrum beta-lactamase (ESBLs), Amp-C-β...
Abstract Background The emerging resistance to the last-resort antimicrobial colistin is being reported globally. Underestimation of burden and misinterpretation susceptibility test results, using suboptimal testing methods, may be causing unexplained treatment failures even mortality among critically ill patients. Thus, this study was conducted at an apex trauma centre assess performance Vitek®2 for testing. Methods A total 910 clinical isolates Gram-negative bacteria (GNB), including...
Bloodstream infections (BSIs) can lead to life-threatening sepsis and are globally associated with high morbidity mortality. Although BSIs require immediate antimicrobial treatment, their prevalence, etiology, susceptibilities differ from one country other. There is a dearth of such data India. Here, we report the 4-year etiologic on BSI in trauma patients admitted tertiary care referral hospital New Delhi, India.A retrospective study was conducted at center between January 2013 December...
The detailed epidemiological and molecular characterization of an outbreak Burkholderia cepacia at a neurotrauma intensive care unit level 1 trauma centre is described. stringent infection control interventions taken to successfully curb this are emphasized.The clinical microbiological data for those patients who had more than one blood culture that grew B. were reviewed. Bacterial identification antimicrobial susceptibility testing was done using automated Vitek 2 systems. Prospective...
Antimicrobial resistance particularly in Gram-negative bacilli is an increasing problem worldwide. Pseudomonas spp. one the most common bacteria associated with nosocomial infections and therefore, its trend of antimicrobial needs to be studied. The aim this study was evaluate rate changes pattern over a period five years (2012-2016) isolated from trauma patients attending tertiary care hospital north India. During study, total 2444 were various clinical sample. species P. aeruginosa (2331,...
The purpose of this study was to estimate the prevalence and characterize carbapenemase-producing Escherichia coli by various phenotypic antimicrobial susceptibility testing methods, its performance compared gold standard genotypic method. carbapenemase-resistant E. found be 65%. methods evaluated are cost-effective can used in resource-limited laboratories rule out carbapenem resistance.
Purpose: To evaluate the association of daily screen time and quality sleep with prevalence dry eye among college-going women. Methods: This study was a cross-sectional, comparative questionnaire-based 547 women in northern India. A 10-item Mini Sleep Questionnaire used to check sleep, Standard Patient Evaluation Eye Dryness (SPEED) scale examine Results: Multinomial logistic regression showed significant between spent ( P < 0.05) girls. Using Latent Class Analysis, two latent classes...
Introduction: Ventilator-associated pneumonia (VAP) remains one of the most common nosocomial infections in Intensive Care Unit. In face extremely high rates antimicrobial resistance, it is essential to gauge clinical significance isolation multidrug-resistant (MDR) pathogens from samples. This study details trend VAP and MDR respiratory samples at an Indian tertiary care hospital. Methods: The was conducted over a 5-year period. diagnosed on basis centres for disease control prevention...
Abstract Objective: Resistance to colistin, a last resort antibiotic, has emerged in India. We investigated colistin-resistant Klebsiella pneumoniae (ColR-KP) hospital India describe infections, characterize resistance of isolates, compare concordance detection methods, and identify transmission events. Design: Retrospective observational study. Methods: Case-patients were defined as individuals from whom ColR-KP was isolated clinical specimen between January 2016 October 2017. Isolates...
Antimicrobial resistance is an increasing problem worldwide especially among the surgical site infections (SSIs). SSI becoming more serious due to hospital-acquired infections/nosocomial infections, which further leads overuse of broad-spectrum antibiotics. To investigate antimicrobial patterns Gram-negative bacteria in in- and out-patients present study was designed.During 4 years (January 2013-December 2016), resistant pattern studied admitted patients who were followed up outpatients...
ABSTRACT Klebsiella pneumoniae is a nosocomial pathogen with clinical importance due to its increasing resistance carbapenems and colistin. Here, we report the genome sequences of eight colistin-resistant K. strains which might help in understanding molecular mechanism species. The sequence data indicate genomes ~5.2 5.4 Mb, along several plasmids.
Nosocomial infections caused by multidrug-resistant, Pseudomonas species have become a major clinical and public health concern. The aim of this study was to characterize phenotypic genotypic profile antimicrobial resistance (AMR) in spp. isolated from hospitalized patients.A total 126 consecutive, non-duplicate isolates various samples were included the over period two years. Identification sensitivity performed using automated culture system according Clinical Laboratory Standards...
Introduction: Antimicrobial-resistant HAI (Healthcare associated infection) are a global challenge due to their impact on patient outcome. Implementation of antimicrobial stewardship programmes (AMSP) is needed at institutional and national levels. Assessment core capacities for AMSP an important starting point initiate nationwide AMSP. We conducted assessment the in network Indian hospitals, which part Global Health Security Agenda-funded work capacity building AMR-HAIs. Subjects Methods:...
Device-associated infections (DAIs) are an important cause of excessive stay and mortality in ICUs. Trauma patients predisposed to acquire such due various factors. The prevalence HAIs is underreported from developing nations a lack systematic surveillance. This study reports the rates outcomes DAIs at dedicated Center trauma compares with previous pilot observation.The finding ongoing surveillance use indigenous software level-1 center India. Surveillance for ventilator-associated...
To evaluate the potential risk factors which increase incidence of post-trauma complications and mortality in pediatric population. A retrospective cohort study was conducted on patients below 18 years age with a fatal outcome who were admitted to an Indian level-1 trauma center between January 2013 December 2015. This analyzed determine demographics, injury mechanism, severity, microbiological profile, cause death. In total, 320 studied showed male preponderance (71.56%). The median 11...