A5011083095- Trauma and Emergency Care Studies
- Trauma Management and Diagnosis
- Autopsy Techniques and Outcomes
- Emergency and Acute Care Studies
- Restraint-Related Deaths
- Injury Epidemiology and Prevention
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Aortic Disease and Treatment Approaches
- Suicide and Self-Harm Studies
- COVID-19 Clinical Research Studies
- Automotive and Human Injury Biomechanics
- Elasticity and Material Modeling
- Palliative Care and End-of-Life Issues
- Forensic Anthropology and Bioarchaeology Studies
- SARS-CoV-2 and COVID-19 Research
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Aortic aneurysm repair treatments
- Cardiac Arrest and Resuscitation
- Neuroscience and Neuropharmacology Research
- Total Knee Arthroplasty Outcomes
- COVID-19 diagnosis using AI
- Traumatic Brain Injury Research
- Forensic Toxicology and Drug Analysis
All India Institute of Medical Sciences
2015-2024
Fortis Escorts Heart Institute
2024
Lok Nayak Jai Prakash Narayan Hospital
2023
All India Institute of Medical Sciences Bhopal
2007-2021
All India Institute of Medical Sciences Raipur
2007-2021
Marymount University
2009
Abstract Angiotensin-converting enzyme 2 (ACE2) is a key host protein by which severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters and multiplies within cells. The level of ACE2 expression in the lung hypothesised to correlate with an increased risk infection complications COrona VIrus Disease 2019 (COVID-19). To test this hypothesis, we compared status immunohistochemistry (IHC) post-mortem samples patients who died COVID-19 obtained from non-COVID-19 for other indications....
Abstract In depth studies of fatal vehicular accidents provide valuable data for implementing effective emergency services to reduce the trauma related mortality and strengthening legal measures in peak hours accidents. We aimed study, pattern injuries especially traumatic brain occurring Postmortem reports clinical records victims road traffic accident autopsied during period 2001–2005 at Department Forensic Medicine Toxicology, All India Institute Medical Sciences, New Delhi, were analyzed...
Device-associated infections constitute the majority of health care-associated (HAIs) in ICUs. Trauma patients are predisposed to acquire such due various trauma-related factors. The prevalence HAIs is underreported from developing nations a lack systematic surveillance. This study reports impact an intensive surveillance on rates and outcome device-associated trauma country compares with previous pilot observation.The was conducted at level-1 centre India. Surveillance for...
ABSTRACT Purpose: Bloodstream infections (BSIs) are one of the major life-threatening in hospitals. They responsible for prolonged hospital stays, high healthcare costs, and significant mortality. The epidemiology BSIs varies between hospitals necessitating analysis local trends. Few studies available on trauma patients, who predisposed due to presence multiple invasive devices. Materials Methods: A prospective surveillance all was done at a level 1 center from April, 2011 March, 2012. All...
Toll-like receptor 3 (TLR3) is a pathogen recognition molecule associated with viral infection double-stranded RNA (dsRNA) as its ligand. We evaluated the role of TLR3 in bacterial pneumonia using Klebsiella pneumoniae (KP). WT and TLR3-/- mice were subjected to lethal model KP. Alveolar macrophage polarization, bactericidal activity, phagocytic capacity compared. RNA-sequencing was performed on alveolar macrophages from mice. Adoptive transfers KP for survival. Expression postmortem human...
OBJECT Mapping of the fascicular anatomy brachial plexus could provide nerve surgeon with knowledge orientation in spinal nerves plexus. This might improve surgical outcome grafting injuries by anastomosing related fascicles and avoiding possible axonal misrouting. The objective this study was to map topography METHODS entire right-sided 25 adult male cadavers dissected, including all 5 (C5-T1), from approximately mm distal their exit intervertebral foramina, proximal 1 cm branches. All were...
Detection and quantification of drugs from various biological matrices are immense importance in forensic toxicological analysis. Despite the reported methods, development a new method for detection is still an active area research. However, every matrix has its own limitation, which further encourage toxicologists to develop methods explore analysis drugs. In this study, electrospray ionization‐liquid chromatograph‐tandem mass spectrometry (ESI‐LC‐MS/MS) developed validated simultaneous...
Blood stream infection (BSI)/bacteremia is a potentially life threatening and are associated with high crude mortality. Coagulase negative Staphylococcus (CONS) aureus the most commonly isolated gram positive bacteria from blood culture samples. While S. known pathogen causing BSIs, CONS considered to be common contaminants of culture. Of late many studies have challenged this traditional viewpoint. The aim study was determine epidemiology significance bacteremia, their resistance patterns...
Glutamate receptor-mediated enhanced excitatory neurotransmission is typically associated with mesial temporal lobe epilepsy hippocampal sclerosis (MTLE-HS). Kynurenic acid and quinolinic are two important tryptophan-kynurenine pathway metabolites that modulate glutamate receptor activity. This study was designed to test the hypothesis alteration in metabolism of hippocampus patients MTLE-HS contributes abnormal glutamatergic transmission.Levels were determined using HPLC LC-MS/MS samples...
Abstract Aim Different deposition patterns and grading systems used to define identify DAI remain discordant date these are a challenge in clinical practice. Our main objective was study the post-mortem axonal changes develop system on basis of histopathological immunoreactive β-amyloid precursor protein (β-APP) observations severe TBI cases. Methods Prospective with 35 decedents sTBI (GCS score ≤ 8) conducted samples were collected from three different sites–corpus callosum, thalamus brain...
Previous research has reported mixed findings on the effect of menstrual cycle suicidal behavior. The contribution menstruation to completed suicide is also controversial, though studies are very limited and have not been carefully designed. To explore relationship, 217 autopsies suicides were performed, matched a control group at All India Institute Medical Sciences in New Delhi. results show that 54.46% people who died by menstruating (results excluded pregnancies), compared 6.75% group....
Organ retrieval from brain dead patients is getting an increased attention as the waiting list for organ recipients far exceeds donor pool. In our country, despite a large population number of donors undergoing donation very less (2% in study).The present study was undertaken to address issues related and share experience same.A retrospective case record analysis over 5 years September 2007 August 2012 performed fulfilling death criterion per Transplantation Human Organs Tissue (Amendment)...
To evaluate the impact of death-to-preservation time (DPT) on effective utilisation donor corneas. In a prospective observational study conducted at our tertiary eye centre, donated corneas received over 15-month period from November 2011 to January 2013 were evaluated. Donor age, refrigeration (done or not), DPT, endothelial cell density (ECD), corneal grading, clinical and surgical outcome after graft transplantation noted. analyse different DPT cornea transplantation, primary measures...
Purpose: To evaluate the diagnostic utility of ante-mortem tracheal aspirates for diagnosis ventilator-associated pneumonia (VAP). Trauma victims represent an otherwise healthy population, who are on multiple invasive life-support devices, which predispose them to severe infections like VAP. The VAP is challenging, due difficulty in obtaining a representative sample from lungs. We studied by comparing its results with post-mortem lung cultures. Materials and Methods: A total 106 fatal trauma...
ABSTRACT Background: There is an alarming rate of morbidity and mortality observed in the trauma victims who suffer spinal cord injuries (SCI). Such patients are admitted immediately stay for longer periods time thus at risk acquiring nosocomial infections. Aims: The aim this study to analyze primary cause SCI patients. Design: Retrospective study. Materials Methods: We conducted a retrospective 4 year analysis postmortem data 341 died after sustaining tertiary care apex center India....