A5059865743- Respiratory Support and Mechanisms
- Trauma and Emergency Care Studies
- Neonatal Respiratory Health Research
- Cardiac Arrest and Resuscitation
- Ultrasound in Clinical Applications
- Emergency and Acute Care Studies
- Ultrasound and Hyperthermia Applications
- Trauma Management and Diagnosis
- Sepsis Diagnosis and Treatment
- Abdominal Trauma and Injuries
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer, Hypoxia, and Metabolism
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Disaster Response and Management
- Appendicitis Diagnosis and Management
- Nosocomial Infections in ICU
- Gallbladder and Bile Duct Disorders
- Airway Management and Intubation Techniques
- Pneumonia and Respiratory Infections
- Traumatic Brain Injury and Neurovascular Disturbances
- Microbial Inactivation Methods
- Congenital Diaphragmatic Hernia Studies
- Injury Epidemiology and Prevention
University of Michigan–Ann Arbor
2016-2025
Michigan Center for Translational Pathology
2023
Michigan Medicine
2010-2022
Collaborative Group (United States)
2022
Washington University in St. Louis
2020
American Association for the Surgery of Trauma
2012-2019
Indiana University – Purdue University Indianapolis
2019
North Memorial Health Care
2019
Regions Hospital
2019
Ann Arbor Center for Independent Living
2012-2019
Abstract Introduction Dental plaque biofilms are colonized by respiratory pathogens in mechanically-ventilated intensive care unit patients. Thus, improvements oral hygiene these patients may prevent ventilator-associated pneumonia. The goal of this study was to determine the minimum frequency (once or twice a day) for 0.12% chlorhexidine gluconate application necessary reduce colonization 175 intubated trauma unit. Methods A randomized, double-blind, placebo-controlled clinical trial tested...
Use of antibiotics for the treatment appendicitis is safe and has been found to be noninferior appendectomy based on self-reported health status at 30 days. Identifying patient characteristics associated with a greater likelihood within days in those who initiate could support more individualized decision-making.To assess factors undergoing initiating appendicitis.In this cohort study using data from Comparison Outcomes Antibiotic Drugs Appendectomy (CODA) randomized clinical trial, among...
<h3>Importance</h3> In the Comparison of Outcomes Antibiotic Drugs and Appendectomy (CODA) trial, which found antibiotics to be noninferior, approximately half participants randomized receive had outpatient management with hospital discharge within 24 hours. If is safe, it could increase convenience decrease health care use costs. <h3>Objective</h3> To assess safety acute appendicitis. <h3>Design, Setting, Participants</h3> This cohort study, a secondary analysis CODA included 776 adults...
Objective: To examine the outcomes of prolonged (≥14 days) extracorporeal membrane oxygenation (P-ECMO) for adult severe respiratory failure and to assess characteristics associated with survival. Background: The use ECMO treatment patients is overall survival rates 50% 70% median duration 10 days. No prior multi-institutional studies have examined P-ECMO failure. Methods: Data on all (≥18 years) who required from 1989 2013 were extracted Extracorporeal Life Support Organization...
For adults with appendicitis, several randomized clinical trials have demonstrated that antibiotics are an effective alternative to appendectomy. However, it remains unknown how the characteristics of patients in such compare those who select their treatment and whether outcomes differ.To participants Comparison Outcomes Antibiotic Drugs Appendectomy (CODA) trial (RCT) a parallel cohort study declined randomization self-selected treatment.The CODA was conducted 25 US medical centers....
Lung contusion affects 17%-25% of adult blunt trauma patients, and is the leading cause death from thoracic injury. A small animal model for isolated bilateral lung has not been developed. We induced in anesthetized rats by dropping a 0.3-kg weight onto precordial protective shield to direct impact force away heart toward lungs. injury was characterized as function chest energy (1.8-2.7 J) measurements arterial oxygenation, bronchoalveolar lavage (BAL) albumin cytology, pressure-volume...
Lung contusion is the leading cause of death from blunt thoracic trauma in adults, but its mechanistic pathophysiology remains unclear. This study uses a recently developed rat model to investigate evolution inflammation and injury isolated lung contusion. Bilateral with minimal cardiac was induced 54 anesthetized rats by dropping 0.3-kg hollow cylindrical weight onto precordial shield (impact energy, 2.45 Joules). Arterial oxygenation, pressure-volume (P-V) mechanics, histology, levels...
Enoxaparin is the only low molecular-weight heparin (LMWH) with documented efficacy for prevention of venous thromboemobolism (VTE) following trauma, and it currently considered treatment choice. Recent reports have suggested that pharmacokinetics (PK) pharmacodynamics LMWH products may be altered in critically ill patients.Two cohorts multiple trauma patients were enrolled this study: A (nonedematous) B (edematous, defined as presence peripheral edema an increase body weight > or =10 kg)....
The fate and distribution of isotopic manganese administered as a single carrier-free dose 200 muCi maleate-(54)Mn to 12 rhesus monkeys was studied at different time periods from the 6th hr 278th day. Whole-body activity measured, all body organs tissues parts central nervous system (CNS) were evaluated for specific activity, exponential analysis, relative retention. Exponential analysis revealed pattern discharge with fast slow component whole many viscera. All CNS and, lesser degree,...
Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury, is associated with reduced compliance and hypoxemia. Curcumin exhibits potent anti-inflammatory properties but has poor solubility rapid plasma clearance. To overcome these physiochemical limitations uncover full therapeutic potential curcumin in inflammation, this study we utilized a novel water-soluble formulation (CDC) delivered it directly into lungs C57BL/6 mice inoculated lethal dose Klebsiella...
Background: To examine the impact of an ongoing comprehensive performance improvement and patient safety (PIPS) program implemented in 2005 on mortality outcomes for trauma patients at established American College Surgeons (ACS)-verified Level I Trauma Center. Methods: The primary outcome measure was in-hospital mortality. Age, Injury Severity Score (ISS), intensive care unit admissions were used as stratifying variables to over a 5-year period (2004–2008). Institution rates compared with...
Recruitment of neutrophils and release reactive oxygen species are considered to be major pathogenic components driving acute lung injury (ALI). However, NADPH oxidase, the source in activated phagocytes, can paradoxically limit inflammation injury. We hypothesized that oxidase protects against ALI by limiting neutrophilic activating Nrf2, a transcriptional factor induces antioxidative cytoprotective pathways. Our objective was delineate roles Nrf2 modulating clinically relevant models...
Interfacility transfer of patients from Level III/IV to I/II (tertiary) trauma centers has been associated with improved outcomes. However, little data are available classifying the specific subsets that derive maximal benefit a tertiary center. Drawbacks include increased secondary overtriage. Here, we ask which injury patterns survival following interfacility transfer.
Background The primary objective of this study was to evaluate the effect specific direct and indirect factors that accounted, in trauma patients, for development acute respiratory distress syndrome (ARDS) mortality patients with ARDS. Methods We performed a retrospective cohort from National Trauma Data Bank. Multilevel mixed-effects logistic regression used ARDS as secondary outcome measures. compared versus without thoracic (direct) extrathoracic (indirect) risk factors, using patient...