A5058609949- Blood transfusion and management
- Blood groups and transfusion
- Hemoglobin structure and function
- Blood donation and transfusion practices
- Erythrocyte Function and Pathophysiology
- Complement system in diseases
- Hemoglobinopathies and Related Disorders
- Glycosylation and Glycoproteins Research
- Neonatal Health and Biochemistry
- Platelet Disorders and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Carbohydrate Chemistry and Synthesis
- Erythropoietin and Anemia Treatment
- Cardiac Arrest and Resuscitation
- Renal Diseases and Glomerulopathies
- Hematopoietic Stem Cell Transplantation
- Drug Transport and Resistance Mechanisms
- Renal Transplantation Outcomes and Treatments
- Enzyme Catalysis and Immobilization
- Multiple Myeloma Research and Treatments
- Iron Metabolism and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Palliative Care and End-of-Life Issues
Massachusetts General Hospital
2010-2020
Harvard University
2009-2020
Center for Global Health
2017
Stony Brook Medicine
2017
Boston Children's Hospital
2017
National Blood Transfusion Service
2007-2016
Brigham and Women's Hospital
2006-2014
Queen's Medical Center
2012
Northwestern University
2012
Williams & Associates
2012
Some observational studies have reported that transfusion of red-cell units been stored for more than 2 to 3 weeks is associated with serious, even fatal, adverse events. Patients undergoing cardiac surgery may be especially vulnerable the effects transfusion.We conducted a randomized trial at multiple sites from 2010 2014. Participants 12 years age or older who were complex and likely undergo red cells randomly assigned receive leukocyte-reduced 10 days less (shorter-term storage group) 21...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-Imino-2-methoxyethyl 1-thioglycosides: new reagents for attaching sugars to proteinsYuan Chuan Lee, Christopher P. Stowell, and Mark J. KrantzCite this: Biochemistry 1976, 15, 18, 3956–3963Publication Date (Print):September 7, 1976Publication History Published online1 May 2002Published inissue 7 September 1976https://pubs.acs.org/doi/10.1021/bi00663a008https://doi.org/10.1021/bi00663a008research-articleACS PublicationsRequest reuse...
Although millions of transfusions are given annually worldwide, the effect red blood cell (RBC) unit storage duration on oxygen delivery is uncertain.To determine if longer-storage RBC units not inferior to shorter-storage for tissue oxygenation as measured by reduction in lactate levels and improvement cerebral saturation among children with severe anemia.Randomized noninferiority trial 290 (aged 6-60 months), most malaria or sickle disease, presenting February 2013 through May 2015 a...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAttachment of thioglycosides to proteins: enhancement liver membrane bindingMark J. Krantz, Neil A. Holtzman, Christopher P. Stowell, Yuan Chuan Lee, Jerry W. Weiner, and Hans H. LiuCite this: Biochemistry 1976, 15, 18, 3963–3968Publication Date (Print):September 7, 1976Publication History Published online1 May 2002Published inissue 7 September 1976https://doi.org/10.1021/bi00663a009RIGHTS & PERMISSIONSArticle Views203Altmetric-Citations128LEARN...
BACKGROUND : Recipient exposure to allogeneic donor WBCs results in transfusion complications for selected populations of recipients. Whether or not WBC reduction should be universally applied is highly controversial. STUDY DESIGN AND METHODS In a general hospital, randomized, controlled clinical trial conversion universal was conducted. Patients (11%) with established medical indications WBC‐reduced blood were eligible. All other patients who required assigned at random receive either...
Prospective, open-label, randomized, parallel-group study at 80 centers.To demonstrate there is no clinically important additional risk for deep vein thrombosis with perioperative use of epoetin alfa versus standard care in spine surgery without prophylactic anticoagulation.Trials orthopedic that demonstrated thrombovascular events included pharmacologic anticoagulation.Subjects received 600 U/kg subcutaneously once weekly starting 3 weeks before spinal plus blood conservation, or alone....
The Harvard TMA Research Collaborative is a multi-institutional registry-based effort to study thrombotic microangiopathies (TMA). Laboratory and clinical parameters were recorded for 254 cases of suspected autoimmune thrombocytopenic purpura (TTP). Patients with severe ADAMTS13 deficiency (activity ≤10%, N = 68) more likely be young, female without history cancer treatment or transplantation. While all patients diagnosed TTP, those frequently had disseminated intravascular coagulation,...
Cardiac surgery is the most common setting for massive transfusion in medically advanced countries. Studies of after injury suggest that ratios administered plasma and platelets (PLT) to red blood cells (RBCs) affect mortality. Data from Red Cell Storage Duration Study (RECESS), a large randomized trial effect RBC storage duration patients undergoing complex cardiac surgery, were analyzed retrospectively investigate association between component used massively transfused subsequent clinical...
Transfusion of erythrocytes stored for prolonged periods is associated with increased mortality. Erythrocytes undergo hemolysis during storage and after transfusion. Plasma hemoglobin scavenges endogenous nitric oxide leading to systemic pulmonary vasoconstriction.We hypothesized that transfusion autologous blood 40 days would increase the artery pressure in volunteers endothelial dysfunction (impaired production oxide). We also tested whether breathing before could prevent pressure.Fourteen...
ABSTRACT A multicenter, randomized, open-label, parallel-group study was conducted to compare the safety and efficacy of perioperative recombinant human erythropoietin (Epoetin alfa) with preoperative autologous donation (PAD) in total joint arthroplasty. 490 patients scheduled for (i.e., hip or knee) surgery having hemoglobin (Hb) levelss ≥ 11 ≤ 13 g/dL were randomized receive weekly doses subcutaneous Epoetin alfa on Days -21, -14, -7, day surgery, participate a PAD program. The mean...
The mannose- and N-acetylglucosamine-specific pathway for the clearance of mammalian glycoproteins has been characterized by using 125I-labelled neoglycoproteins, glycosidase-treated orosomucoid lysosomal glycosidases (beta-glucuronidase beta-N-acetylglucosaminidase) as probes. There are two components to this in vivo; one liver-dependent other extrahepatic or liver-independent. Cells that mediate latter component present spleen, bone elements reticuloendothelial system, but not kidney....
The binding of D-glucosyl-neoglycoproteins and D-galactose-terminated glycoproteins to the hepatic asialoglycoprotein receptor rabbit liver membranes were characterized compared. both types showed same dependence on calcium concentration, sensitivity neuraminidase, degree inhibition by various carbohydrate derivatives. These results, along with observation that bound D-glucosyl- D-galactosyl-terminated extent, indicated receptor. To confirm this hypothesis, receptors isolated from livers...
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatality reported to Food and Drug Administration. Donor screening may reduce TRALI risk. This study sought compare efficacy safety different risk-reduction strategies at a hospital-based donor center.Samples from 1053 donors who answered questions regarding pregnancy transfusion history were tested for HLA Class I II antibodies using flow cytometry-based assay. was compared with presence...
During extended storage, erythrocytes undergo functional changes. These changes reduce the viability of leading to release oxyhemoglobin, a potent scavenger nitric oxide. We hypothesized that transfusion ovine packed (PRBC) stored for prolonged periods would induce pulmonary vasoconstriction in lambs, and reduced vascular oxide concentrations increase this vasoconstrictor effect.We developed model autologous blood lambs (n = 36). Leukoreduced was either 2 days (fresh PRBC) or 40 (stored...
BACKGROUND Pathogen inactivation (PI) is a new approach to blood safety that may introduce additional costs. This study identifies costs could be eliminated, thereby mitigating the financial impact. STUDY DESIGN AND METHODS Cost information was obtained from five institutions on tests and procedures (e.g., irradiation) currently performed, eliminated. The impact of increased platelet (PLT) availability due fewer testing losses, earlier entry into inventory, outdates with 7‐day shelf life...