A5079746187- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Cardiac Arrest and Resuscitation
- Nosocomial Infections in ICU
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Hemodynamic Monitoring and Therapy
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Electrical and Bioimpedance Tomography
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Plant Physiology and Cultivation Studies
- Anesthesia and Neurotoxicity Research
- Blood transfusion and management
- Healthcare Decision-Making and Restraints
- Cardiac Ischemia and Reperfusion
- Horticultural and Viticultural Research
- Cardiac, Anesthesia and Surgical Outcomes
- Nitric Oxide and Endothelin Effects
Massachusetts General Hospital
2016-2025
Harvard University
2015-2025
Boston University
2006-2024
Pain and Rehabilitation Medicine
2013-2024
Università Cattolica del Sacro Cuore
2024
Agostino Gemelli University Polyclinic
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Chinese PLA General Hospital
2023
National Clinical Research
2023
Center for Pain and the Brain
2013-2022
Abstract Children and adolescents account for ~ 13% of total COVID-19 cases in the United States. However, little is known about nature illness children. The reopening schools underlines importance understanding epidemiology pediatric infections. We sought to assess clinical characteristics outcomes patients. conducted a retrospective cross-sectional analysis patients diagnosed with from healthcare organizations study (hospitalization, mechanical ventilation, critical care) were assessed...
Abstract Background Although tracheostomy is probably the most common surgical procedure performed on critically ill patients, it unknown when a tube can be safely removed. Methods We cross-sectional survey of physicians and respiratory therapists with expertise in management tracheostomized patients at 118 medical centers to characterize contemporary opinions about decannulation practice define factors that influence these practices. Results surveyed 309 clinicians, whom 225 responded...
No medical intervention has been identified that decreases acute kidney injury and improves renal outcome at 1 year after cardiac surgery.
Objective: The approach to applying positive end-expiratory pressure in morbidly obese patients is not well defined. These frequently require prolonged mechanical ventilation, increasing the risk for failed liberation from ventilatory support. We hypothesized that lung recruitment maneuvers and titration of were both necessary improve volumes elastic properties lungs, leading improved gas exchange. Design: Prospective, crossover, nonrandomized interventional study. Setting: Medical surgical...
Atelectasis develops in critically ill obese patients when undergoing mechanical ventilation due to increased pleural pressure. The current study aimed determine the relationship between transpulmonary pressure, lung mechanics, and morphology quantify benefits of a decremental positive end-expiratory pressure trial preceded by recruitment maneuver.Prospective, crossover, nonrandomized interventional study.Medical Surgical Intensive Care Units at Massachusetts General Hospital (Boston, MA)...
BACKGROUND: Rescue therapies to treat or prevent progression of coronavirus disease 2019 (COVID-19) hypoxic respiratory failure in pregnant patients are lacking. METHOD: To meeting criteria for severe critical COVID-19 with high-dose (160–200 ppm) nitric oxide by mask twice daily and report on their clinical response. EXPERIENCE: Six were admitted at Massachusetts General Hospital from April June 2020 received inhalational therapy. All tested positive acute syndrome 2 (SARS-CoV-2) infection....
Obese patients are characterized by normal chest-wall elastance and high pleural pressure have been excluded from trials assessing best strategies to set positive end-expiratory (PEEP) in acute respiratory distress syndrome (ARDS). The authors hypothesized that severely obese with ARDS present a degree of lung collapse, reversible titrated PEEP preceded recruitment maneuver.Severely were enrolled physiologic crossover study evaluating the effects three titration applied following order: (1)...
Inhaled nitric oxide (NO) is a selective pulmonary vasodilator. In-vitro studies report that NO donors can inhibit replication of SARS-CoV-2. This multicenter study evaluated the feasibility and effects high-dose inhaled in non-intubated spontaneously breathing patients with Coronavirus disease-2019 (COVID-19). an interventional to determine whether at 160 parts-per-million (ppm) for 30 min twice daily might be beneficial safe COVID-19 patients. Twenty-nine received total 217 intermittent...
The effects of high-dose inhaled nitric oxide on hypoxemia in coronavirus disease (COVID-19) acute respiratory failure are unknown.
Positive end-expiratory pressure (PEEP) can potentially modulate inspiratory effort (ΔPes), which is the major determinant of self-inflicted lung injury.
Objective: Continuous aspiration of subglottic secretions (CASS) is believed to lower the incidence ventilator-associated pneumonia. Animal studies establish safety and efficacy CASS have not been conducted. Design: Prospective randomized animal study. Setting: Animal-research facility at U.S. National Institutes Health. Subjects: Twenty-two sheep. Interventions: Sheep were into three groups. In group C (control), eight sheep kept prone, intubated with a standard endotracheal tube (ETT),...
Objective: To examine the longitudinal outcome of a cohort mechanically ventilated patients admitted to an acute care respiratory unit after critical illness. Design, Setting, and Patients: Prospective, observational study 210 consecutive acute, tertiary university hospital, who had illness with failure. The was powered develop multivariate regression models investigate relationship between patient characteristics a) liberation from mechanical ventilation b) survival. Interventions: None....
Transfusion of erythrocytes stored for prolonged periods is associated with increased mortality. Erythrocytes undergo hemolysis during storage and after transfusion. Plasma hemoglobin scavenges endogenous nitric oxide leading to systemic pulmonary vasoconstriction.We hypothesized that transfusion autologous blood 40 days would increase the artery pressure in volunteers endothelial dysfunction (impaired production oxide). We also tested whether breathing before could prevent pressure.Fourteen...
Limited data exist regarding ventilation in patients with class III obesity [body mass index (BMI) > 40 kg/m2] and acute respiratory distress syndrome (ARDS). The aim of the present study was to determine whether an individualized titration mechanical according cardiopulmonary physiology reduces mortality ARDS.In this retrospective study, we enrolled adults admitted ICU from 2012 2017 who had ARDS received for 48 h. Enrolled were divided two cohorts: one cohort (2012-2014) ventilator...