A5102820098- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Cancer Immunotherapy and Biomarkers
- Aortic aneurysm repair treatments
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Social and Demographic Issues in Germany
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Appendicitis Diagnosis and Management
- Lung Cancer Diagnosis and Treatment
- Immune Response and Inflammation
- Cancer Genomics and Diagnostics
- Shoulder Injury and Treatment
- Sepsis Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Nerve Injury and Rehabilitation
- Shoulder and Clavicle Injuries
Universitätsklinikum Erlangen
2016-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Comprehensive Cancer Center Erlangen
2024
Queen Elizabeth Hospital Birmingham
2021-2022
Technische Universität Berlin
2016
Harvard University
1991-2016
Center for Systems Biology
2016
Massachusetts General Hospital
2016
University Hospital Carl Gustav Carus
2016
Helios Kliniken
2016
We aimed to determine the effect of hospital volume on in-hospital mortality, and failure rescue following major pancreatic resections using discharge data every inpatient case in Germany.Several studies have found strong volume-outcome relationships surgery, with high mortality low-volume facilities. However, their datasets were only based portions national populations. In addition, these did not assess according other crucial variables such as medical indications, postoperative...
We aimed to determine the unbiased mortality rates for pancreatic surgery procedures at national level through a comprehensive analysis of every inpatient case in Germany.Several studies have proclaimed general improvement perioperative outcomes following surgery. These results are challenged by recent analyses large US databases that found strong volume-outcome relationships, with high low-volume facilities.All cases procedure code Germany from 2009 2013 were identified nationwide...
Macrophages play an important role in structural cardiac remodeling and the transition to heart failure following myocardial infarction (MI). Previous research has focused on impact of blood-derived monocytes repair. Here we examined contribution resident cavity macrophages located pericardial space adjacent site injury. We found that disruption accelerated maladaptive post-MI remodeling. Gata6+ mouse fluid contributed reparative immune response. Following experimental MI, these invaded...
Sepsis is an often fatal condition that arises when the immune response to infection causes widespread systemic organ injury. A critical unmet need in combating sepsis lack of accurate early biomarkers produce actionable results busy clinical settings. Here, we report development a point-of-care platform for rapid detection. Termed IBS (integrated biosensor sepsis), our approach leverages (i) pathophysiological role cytokine interleukin-3 (IL-3) and (ii) hybrid magneto-electrochemical sensor...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide health threat. In prospective multicentric study, we identify IL-3 as an independent prognostic marker for the outcome during SARS-CoV-2 infections. Specifically, low plasma levels associated with increased severity, viral load, and mortality Patients severe COVID-19 exhibit also reduced circulating plasmacytoid dendritic cells (pDCs) IFNα IFNλ when compared to non-severe patients. mouse model of pulmonary...
High-risk human papillomaviruses (HPVs) are associated with carcinomas of the cervix and other genital tumors. The HPV oncoprotein E6 is essential for oncogenic transformation. We identify here hADA3, homologue yeast transcriptional coactivator yADA3, as a novel E6-interacting protein target E6-induced degradation. hADA3 binds selectively to high-risk proteins only immortalization-competent mutants. functions p53-mediated transactivation by stabilizing p53 protein. Notably, three...
Despite recent advances in activating immune cells to target tumors, the presence of some cells, such as tumor-associated macrophages (TAMs) or neutrophils (TANs), may promote rather than inhibit tumor growth. However, it remains unclear how antibody-dependent immunotherapies, cytotoxic checkpoint control antibodies, affect different TAM TAN populations, which abundantly express Fcγ receptors. In this study, we show that tissue environment determines cellular effector pathways are...
Three-dimensional (3-D) volume rendering has been shown to improve visualization in general surgery. Cinematic (CR), a novel 3-D technology for postprocessing of computed tomographaphy (CT) images, provides photorealistic images with the potential anatomic details.To determine value CR comprehension surgical anatomy.This preclinical, randomized, 2-sequence crossover study was conducted from February November 1, 2018, at University Hospital Erlangen, Germany. The 40 patient cases were...
The prognosis of pancreatic ductal adenocarcinoma (PDAC) is one the most dismal all cancers and median survival PDAC patients only 6-8 months after diagnosis. While decades research effort have been focused on early diagnosis understanding molecular mechanisms, few clinically useful markers universally applied. To improve treatment management PDAC, it equally relevant to identify prognostic factors for optimal therapeutic decision-making patient survival. Compelling evidence suggested...
Inflammatory bowel diseases (IBDs) are a global health issue with an increasing incidence. Although the pathogenesis of IBDs has been investigated intensively, etiology remains enigmatic. Here, we report that interleukin-3 (Il-3)-deficient mice more susceptible and exhibit increased intestinal inflammation during early stage experimental colitis. IL-3 is locally expressed in colon by cells harboring mesenchymal stem cell phenotype protects promoting recruitment splenic neutrophils high...
The poor prognosis of pancreatic ductal adenocarcinoma (PDAC) is largely due to several challenges, such as late diagnosis, early metastasis, limited response chemotherapy, aggressive tumor biology, and high rates recurrence. Therefore, the development a non-invasive effective method for detection PDAC crucial improving patient outcomes. Continued research exploration in this area are essential enhance methods ultimately improve individuals with PDAC. In study, we examined 37 exosomal...
Abstract The aim of the present study was to identify risk factors associated with postoperative morbidity and mortality in patients undergoing isolated left pancreatectomy those pancreatic resection as part a multivisceral resection. We performed retrospective analysis 296 adult who underwent elective from 2005 2022 at University Hospital Erlangen. Patient demographics, pre- intraoperative findings, along outcomes, were collected tested predictive for various short-term parameters. Isolated...
Pancreatic ductal adenocarcinoma (PDAC) is aggressive, with a 5-year survival rate of only 12.8%, and its increasing incidence in Western countries highlights the urgent need for better early-stage detection treatment methods. Early diagnosis significantly improves chances survival, but non-specific symptoms undetectable precursor lesions pose major challenge. To date, there are no reliable screening tools to detect PDAC at an early stage. Herpesvirus entry mediator (HVEM) has already been...
Summary Aims To investigate the clinical significance of determination IgA antibodies to tissue transglutaminase (tTG) for detection silent coeliac disease in patients with Type 1 diabetes mellitus. Methods A total 520 (median age 14.2 years, range 1–27) were tested tTG (IgA anti‐tTG, ELISA), endomysium (EmA, indirect immunofluoresence) and gliadin (IgA‐AGA, enzyme immunometric assay) after ruling out deficiency. Results The prevalence anti‐tTG among was 4.4% (23 520), that EmA IgA‐AGA 3.5%...
Abstract IL-22 is a recently discovered cytokine of the IL-10 family that binds to class II receptor composed IL-22R1 and IL-10R2c influences variety immune reactions. As has also been shown modulate cell cycle proliferation mediators such as ERK1/2 JNK, we studied role in proliferation, apoptosis, regulation EMT6 murine breast cancer cells vitro vivo. In this study, report express functional IL-22R indicated by RT-PCR studies, immunoblotting, STAT3 activation assays. Importantly, exposure...
Pancreatic cancer is the fourth leading cause for cancer-related death, and early diagnosis one key to improve survival rate of this disease. Molecular biomarkers are an important method diagnostic use in pancreatic cancer. We used data from three mRNA microarray datasets a microRNA dataset (GSE16515, GSE15471, GSE28735, GSE41372) identify potential genes. Differentially expressed genes (DEGs) microRNAs (DEMs) were identified. Functional, pathway enrichment, protein-protein interaction...