A5045694865- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Surgical Simulation and Training
- Metastasis and carcinoma case studies
- Enhanced Recovery After Surgery
- Dietary Effects on Health
- Angiogenesis and VEGF in Cancer
- Anatomy and Medical Technology
- Lymphatic Disorders and Treatments
- Airway Management and Intubation Techniques
- Glioma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Vascular anomalies and interventions
- Inflammatory Biomarkers in Disease Prognosis
- Stoma care and complications
- Ovarian cancer diagnosis and treatment
- Thyroid and Parathyroid Surgery
- Obesity and Health Practices
- Gastrointestinal disorders and treatments
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
Krankenhaus Nordwest
2021-2025
University Hospital Frankfurt
2023
Goethe University Frankfurt
2023
Universitätsklinikum Erlangen
2019-2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019
This trial evaluates the addition of PD-L1 antibody atezolizumab (ATZ) to standard-of-care fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) as a perioperative treatment for patients with resectable esophagogastric adenocarcinoma (EGA).
Obesity has become a major health problem in the industrialized world. Immune regulation plays an important role adipose tissue homeostasis; however, initial events that shift balance from noninflammatory homeostatic environment toward inflammation leading to obesity are poorly understood. Here, we report for costimulatory molecule programmed death-ligand 1 (PD-L1) limitation of diet-induced obesity. Functional ablation PD-L1 on dendritic cells (DCs) using conditional knockout mice increased...
Three-dimensional (3-D) volume rendering has been shown to improve visualization in general surgery. Cinematic (CR), a novel 3-D technology for postprocessing of computed tomographaphy (CT) images, provides photorealistic images with the potential anatomic details.To determine value CR comprehension surgical anatomy.This preclinical, randomized, 2-sequence crossover study was conducted from February November 1, 2018, at University Hospital Erlangen, Germany. The 40 patient cases were...
Abstract Background The main reason for treatment failure after curative surgical resection of gastric cancer is intra-abdominal spread, with 40–50% peritoneal seeding as primary localization recurrence. Peritoneal relapse seen in 60–70% tumors diffuse type, compared to only 20–30% intestinal type. Hyperthermic IntraPEritoneal Chemoperfusion (HIPEC) an increasingly used therapy method patients metastases. preventive use HIPEC could represent elegant approach (pts) before macroscopic seeding,...
This multicenter, randomized phase II/III study evaluated the addition of vascular endothelial growth factor receptor-2 inhibitor ramucirumab to FLOT as perioperative treatment for resectable esophagogastric adenocarcinoma. Patients received either alone (Arm A) or combined with followed by monotherapy B). The primary endpoint II portion was pathological complete subtotal response (pCR/pSR) rate. Baseline characteristics were comparable between both arms a high rate tumors signet-ring cell...
Abstract Background Although addition of adjuvant chemotherapy is the current standard, prognosis pancreatic cancers still remains poor. The NEPAFOX trial evaluated perioperative treatment with FOLFIRINOX in resectable cancer. Patients and Methods This multicenter phase II randomized patients or borderline cancer without metastases into arm (A,) upfront surgery plus gemcitabine, (B,) FOLFIRINOX. primary endpoint was overall survival (OS). Results Owing to poor accrual, recruitment...
Background: Thoracic duct ligation (TDL) during esophagectomy has been proposed to reduce the risk of postoperative chylothorax. Because its role in immunoregulation, some authors argued that it had an unfavorable TDL effect on survival. The aim this study was analyze overall survival (OS). Methods: PubMed, MEDLINE, Scopus, and Web Science were searched through December 2023. primary outcome 5-year OS. restricted mean time difference (RMSTD), hazard ratios (HRs), 95% confidence intervals...
Introduction: Standard-of-care gastroesophageal reflux disease (GERD) procedures are associated with adverse events (AEs) (i.e., dysphagia, gas-bloating). RefluxStop has been developed to circumvent these outcomes. This study presents the results of 28 patients managed in Germany. Methods: Between July 2021 and November 2023, GERD underwent surgery, a novel laparoscopic antireflux procedure. Retrospective chart analysis patient-informed consent was conducted determine clinical outcomes, such...
We aimed to determine the impact of surgical experience and frequency practice on perioperative morbidity mortality in pancreatic surgery.1281 patients that underwent resections from 1993 2013 were retrospectively analyzed using logistic regression models. All cases stratified according surgeon's level experience, which was based number previously performed extent received supervision (novice: n < 20 / intensive; intermediate: = 21-90 decreasing; experienced surgeon: > 90 none). Additional...
Purpose: This study aims to explore the feasibility and implications of Ramadan fasting for patients who have undergone laparoscopic sleeve gastrectomy (LSG), assessing impacts on hydration, nutrient intake, weight management, gastrointestinal symptoms. Methods:A prospective online survey was conducted among 218 LSG 83 control individuals with obesity had not surgery.Participants were surveyed before after Ramadan, providing data practices, hunger satiety levels, fluid occurrence...
Portomesenteric vein thrombosis (PMVT) is a rare post-operative complication of bariatric procedures, occurring in between 0.3% and 1% cases. A structured questionnaire consisting 27 items was available online to members the International Federation for Surgery Obesity Metabolic Disorders (IFSO) investigate occurrence PMVT. total 89 surgeons from 61 countries participated. Twenty-six (29.21%) reported at least one case PMVT (46.15% males; 53.84% females). The surgery most associated with...
Abstract Background Gastroesophageal reflux disease (GERD) is a troublesome gastrointestinal ailment with significant prevalence worldwide. First-line treatment attempted proton pump inhibitor (PPI) therapy, but about 40% of patients experience irresponsiveness. Inadequate response, intolerance, or aversion to long-term therapy are indications for anti-reflux surgery. Fundoplication techniques, magnetic sphincter augmentation, and endoscopic techniques existing surgical options, often...
Abstract Background The most common gastrointestinal disorder globally is gastroesophageal reflux disease (GERD). Standard-of-care treatments for GERD are medical therapy, via proton pump inhibitors (PPIs), and traditional antireflux surgery (i.e., Nissen fundoplication). Unfortunately, PPI therapy associated with medication irresponsiveness in up to 40% of cases fundoplication results significant rates postoperative adverse events (AEs), such as dysphagia. Notably, patients large hiatal...
Abstract This article presents an alternative technique to the common Toupet fundoplication. It is a modern combination of standard procedure and additional fundophrenicopexie gastric wrap. In 1963 first described his fundoplication for reflux surgery. Over past years this has been modified expanded many times. We have learned that short vessels need be divided get wrap closer easier around esophagus. Furthermore, it likely necessary perform balanced hiatoplasty avoid slippage Our...
Abstract Post-thyroidectomy bleeding is a fortunately rare but potentially life-threatening complication that may increase postoperative morbidity and hospital stay. In this case series, we demonstrate the relation between measurement of neck circumference haemorrhage following thyroid surgery value in predicting post-thyroidectomy haemorrhage. Currently, there no simple reliable method available for early detection bleeding. Continuous pressure could be potential tool invasive, more data...
Introduction Axial hiatal hernias are a common incidental finding in endoscopical examinations, but reflux symptoms do not necessarily correspond to the presence of hernias. Diagnosing disease is difficult due leak existing distinct criteria, especially order evaluate surgical indication. Also preoperative measurement hernia necessary choose between options. Methods and analysis We planned semiblinded trial including questionnaire an oesophagogastroduodenoscopy afterwards. While endoscopy...
Anastomotic leak is a major cause of morbidity and mortality patients worldwide, it has remained stable over the last years. Routine construction protective ileostomy associated with stoma negatively affects patients' quality life. Developing another technique to minimize those drawbacks at least same clinical success can help anastomotic leak. We present novel "Hidden Ileostomy" as an alternative that achieve balance.Eight presented our department underwent rescue procedure for different...