A5085809154- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Ovarian cancer diagnosis and treatment
- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- Dermatological and COVID-19 studies
- Gastrointestinal disorders and treatments
- Esophageal Cancer Research and Treatment
- Hernia repair and management
- Pleural and Pulmonary Diseases
- Intestinal and Peritoneal Adhesions
- Uterine Myomas and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- Occupational and environmental lung diseases
- Esophageal and GI Pathology
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2002-2024
Freie Universität Berlin
2018-2024
Klinikum im Friedrichshain
2024
Texas Oncology
2024
Universität Ulm
1993-2023
MSB Medical School Berlin
2005-2022
University of Manchester
2021
Shadyside Hospital
2018
University of Pittsburgh Medical Center
2018
In patients with peritoneal metastasis (PM) from gastric cancer (GC), chemotherapy is the treatment of choice. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal (HIPEC) are still being debated. This randomized, controlled, open-label, multicenter phase III trial (EudraCT 2006-006088-22; ClinicalTrials.gov identifier: NCT02158988) explored impact on overall survival (OS) HIPEC after CRS.
Background— Infection of pancreatic necrosis has a major impact on clinical course, management, and outcome in acute pancreatitis. Currently, guided fine needle aspiration is the only means for an early accurate diagnosis infected necrosis. Procalcitonin (PCT), 116 amino acid propeptide calcitonin, interleukin 8 (IL-8), strong neutrophil activating cytokine, are markers severe inflammation sepsis. Aims— To analyse value PCT IL-8 as biochemical parameters predicting Patients methods— Fifty...
The risk factors predisposing to organ failure in patients with necrotizing pancreatitis remain unclear. relationship between the extent of pancreatic necrosis, presence infection and incidence was analysed.In a retrospective review, occurrence pulmonary insufficiency, renal shock, sepsis/sepsis-like syndrome (SLS) coagulopathy evaluated 273 pancreatitis, comparison made sterile or infected necrosis. Additionally, relation parenchymal necrosis investigated by classifying into three groups...
Magnetic fluid hyperthermia (MFH) is a new approach to deposit heat power in deep tissues by overcoming limitations of conventional treatments. After infiltration the target tissue with nanosized magnetic particles, an alternating field transformed into heat. The combination 100 kHz applicator and magnetofluid (MF), which both are designed for medical use, investigated respect its dosage recommendations clinical applicability. We found strength up 18 kA/m cylindrical treatment area 20 cm...
Abstract Background Early detection of infected pancreatic necrosis has a major impact on further management and outcome in acute pancreatitis. The aim this study was to evaluate the clinical value ultrasonographically guided fine-needle aspiration cytology (FNAC) patients with necrotizing pancreatitis over an 8-year period. Methods From January 1988 September 1996 193 (mean 2·0 (range 1–9) aspirations per patient) prospectively assessed FNACs were performed 98 proven by contrast-enhanced...
Enhanced recovery after surgery (ERAS) pathways have been shown to considerably reduce complications, length of stay and costs most surgical procedures by standardised application best evidence-based perioperative care. The aim was elaborate dedicated recommendations for cytoreductive (CRS) ± hyperthermic intraperitoneal chemotherapy (HIPEC) in a two-part series guidelines based on expert consensus. present part II the highlights postoperative management special considerations.The core group...
Trastuzumab is the only approved targeted drug for first-line treatment of human epidermal growth factor receptor 2-positive (HER2+) metastatic gastric cancer (mGC). However, not all patients respond and most eventually progress. The multicenter VARIANZ study aimed to investigate background response resistance trastuzumab in mGC.Patients receiving medical mGC were prospectively recruited 35 German sites followed up 48 months. HER2 status was assessed centrally by immunohistochemistry...
We investigated p53 and its downstream effectors p21WAF1/CIP1, BAX, hMSH2 as well the proliferation marker Ki-67 (mki-67/MIB-1) in patients undergoing preoperative radiochemotherapy for rectal carcinoma to identify prognostic predictive factors. The focus of this study was on dynamics these genetic markers a longitudinal study-that is, before after radiochemotherapy.Expression p53, Ki-67, by immunohistochemistry pre- posttherapeutic tumor samples 66 patients. Tumor DNA screened mutations...
Abstract Aim The aim of this official guideline published by the German Society Gynecology and Obstetrics (DGGG) coordinated with Urology (DGU) Reproductive Medicine (DGRM) is to provide consensus-based recommendations, obtained evaluating relevant literature, on counseling fertility preservation for prepubertal girls boys as well patients reproductive age. Statements recommendations women are presented below. or men not focus guideline. Methods This S2k was developed at suggestion...
Abstract Introduction Colorectal carcinomas represent the third most common cause of cancer-related deaths in Germany. Although incidence is significantly higher men compared with women and gender a well-established crucial factor for outcome other diseases, detailed comparisons colon cancer are lacking. Methods This retrospective population-based cohort study included all patients diagnosed Germany between 2000 2016 who were dataset colorectal from quality conference German Cancer Society....