A5068189608- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Medical Imaging Techniques and Applications
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- MRI in cancer diagnosis
- Gallbladder and Bile Duct Disorders
- Advanced MRI Techniques and Applications
- Renal cell carcinoma treatment
- Pancreatitis Pathology and Treatment
- Radiopharmaceutical Chemistry and Applications
- Pediatric Hepatobiliary Diseases and Treatments
- Advanced X-ray and CT Imaging
- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Radiation Dose and Imaging
Leipzig University
2019-2025
University Hospital Leipzig
2019-2025
University Medical Center
2023-2024
University of Groningen
2023
University Medical Center Groningen
2023
Charité - Universitätsmedizin Berlin
2013-2022
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2021-2022
European Organisation for Research and Treatment of Cancer
2022
Amsterdam University Medical Centers
2022
Humboldt-Universität zu Berlin
2010-2020
however, is covered in this chapter, since early recognition and treatment important for complication of carcinoid syndrome.Since highly proliferative carcinomas with a neuroendocrine phenotype but poor histological differentiation grade are extremely rare the jejuno-ileum, management such cases remains individual can currently not be considered standardised according to organ-oriented guidelines.For cases, reader referred previous guidelines [4] .This therefore, deals non-metastatic NEN...
The objective of this study was to evaluate the impact positron emission tomography (PET) using fluorine-18-fluorodeoxyglucose (FDG) for initial staging and therapy planning in pediatric sarcoma patients.In prospective multicenter study, 46 patients (females, n = 22; males, 24; age range, 1 18 years) with histologically proven (Ewing family tumors, 23; osteosarcoma, 11; rhabdomyosarcoma, 12) were examined conventional imaging modalities (CIMs), including ultrasound, computed (CT), magnetic...
Advanced pancreatic cancer (APC), in addition to its high mortality, accounts for the highest rates of venous thromboembolic events (VTEs). Enoxaparin, a low-molecular weight heparin, is effective prevention and treatment VTEs. Some small studies have indicated that this benefit might extend patients with cancer.Patients histologically proven APC were randomly assigned ambulant first-line chemotherapy prophylactic use enoxaparin or alone investigate probable reduction symptomatic VTEs impact...
Data regarding the diagnosis, management, and follow-up of carcinoid syndrome (CS) heart disease (CHD) were identified by searches MEDLINE database using specific terms in human studies: CS; CHD; screening; epidemiology; diagnosis; treatment; prognosis. The search results supplemented manual searching relevant journals, reference lists key articles other appropriate documents, expert opinion. All recommendations are offered on basis best available evidence, authors' experiences managing CS...
Abstract This ENETS guidance paper for well‐differentiated nonfunctioning pancreatic neuroendocrine tumours (NF‐Pan‐NET) has been developed by a multidisciplinary working group, and provides up‐to‐date practical advice on the management of these tumours. Using extensive experience centres treating patients with NF‐Pan‐NEN, authors this discuss 10 troublesome questions in everyday clinical practice. Our many years field are still being verified light results new clinical, which set ways...
Abstract Background Posthepatectomy liver failure (PHLF) contributes significantly to morbidity and mortality after surgery. Standardized assessment of preoperative function is crucial identify patients at risk. These European consensus guidelines provide guidance for patient assessment. Methods A modified Delphi approach was used achieve consensus. The expert panel consisted hepatobiliary surgeons, radiologists, nuclear medicine specialists, hepatologists. guideline process supervised by a...
To retrospectively compare the diagnostic accuracy of three cardiac magnetic resonance (MR) imaging approaches for detection histologic and immunohistologic criteria (reference standard) proved myocardial inflammation in patients clinically suspected having chronic myocarditis (CMC).Cardiac MR was performed 83 consecutive (55 male, 28 female; mean age, 44.8 years +/- 17.7 [standard deviation]) CMC, after written informed consent obtained according to guidelines local ethics committee, which...
Purpose In adult Hodgkin's lymphoma (HL) risk stratification after early therapy response assessment with [ 18 F]fluorodeoxyglucose (FDG) positron emission tomography (PET) seems to allow tailoring less toxicity for patients adequate metabolic response. This study delivers the first prospective data on potential of FDG-PET in pediatric HL. Patients and Methods was performed 40 HL before polychemotherapy (PET-1), two cycles (PET-2), completion (PET-3). Mean follow-up 46 months (range, 26 72...
<i>Aim:</i> Retrospective evaluation of the impact integrated positron emission tomography/computed tomography (PET/CT) using <sup>68</sup>Ga-DOTA(0)-Phe(1)-Tyr(3)-octreotide (<sup>68</sup>Ga-DOTATOC) on therapeutic management patients with neuroendocrine tumors (NET). <i>Methods:</i> The <sup>68</sup>Ga-DOTATOC-PET/CT data 66 (31 male, 35 female; age: 29–79, mean 56 years) known or suspected NET were included. Imaging (PET and...
Abstract Background This multicentre international randomized trial compared the impact of gadoxetic acid-enhanced magnetic resonance imaging (MRI), MRI with extracellular contrast medium (ECCM-MRI) and contrast-enhanced computed tomography (CE-CT) as a first-line method in patients suspected colorectal cancer liver metastases (CRCLM). Methods Between October 2008 September 2010, CRCLM were to one three modalities. The primary endpoint was proportion for whom further after initial required...
Patients with increased liver stiffness have a higher risk of developing cancer, however, the role fluid-solid tissue interactions and their contribution to tumor malignancy remains elusive. Tomoelastography is novel imaging method for mapping quantitatively solid-fluid properties soft tissues in vivo. It provides high resolution thus has clear clinical applications. In this work we used tomoelastography 77 participants, total 141 focal lesions different etiologies, investigate contributions...
Abstract The liver has the remarkable capacity to regenerate. In clinic, regeneration is induced by portal vein embolization, which redirects blood flow, resulting in hypertrophy locations with increased supply, and atrophy of embolized segments. Here, we apply single-cell single-nucleus transcriptomics on healthy, hypertrophied, atrophied patient-derived samples explore cell states regenerating liver. Our data unveils pervasive upregulation genes associated developmental processes, cellular...
The diagnostic value of neuroendocrine tumor (NET) imaging using PET with integrated CT is dependent on both components. This retrospective study assessed the single phases a triple-phase (early arterial, portal-venous inflow, and venous) protocol in comparison to (68)Ga-DOTATOC masked reading.(68)Ga-DOTATOC PET/CT examinations from 51 patients known or suspected NET were included. Two readers data each 3 for lesions independently (using 3-point score: 1 = benign, 2 indeterminate, malignant)...
Abstract Background Texture analysis derived from computed tomography (CT) can provide clinically relevant imaging biomarkers. Node-RADS is a recently proposed classification to categorize lymph nodes in radiological images. The present study sought investigate the diagnostic abilities of CT texture and discriminate benign malignant mediastinal patients with lung cancer. Methods Ninety-one ( n = 32 females, 35%) mean age 64.8 ± 10.8 years were included this retrospective study. was performed...
Abstract Background In advanced neuroendocrine tumors (NET), antiproliferative treatment options beyond somatostatin analogs remain limited. Temozolomide (TMZ) has shown efficacy in NET alone or combined with other drugs. Materials and Methods SONNET (NCT02231762) was an open, multicenter, prospective, phase II study to evaluate lanreotide autogel 120 mg (LAN) plus TMZ patients progressive advanced/metastatic grade 1/2 gastroenteropancreatic (GEP) of unknown primary. Patients could be...
Abstract Objective The Node-RADS classification was recently published as a system to better characterize lymph nodes in oncological imaging. present analysis investigated the diagnostic benefit of staging computed tomography (CT) images categorize and stage patients with colon cancer. Materials methods All were surgically resected histopathological analyzed. scored accordance by two experienced radiologists. Interreader variability assessed Cohen’s kappa analysis, discrimination performed...