A5055571290- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Cardiac Imaging and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced X-ray and CT Imaging
- Liver Disease Diagnosis and Treatment
- Radiation Dose and Imaging
- Lanthanide and Transition Metal Complexes
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Spondyloarthritis Studies and Treatments
- Orthopaedic implants and arthroplasty
- Bone health and osteoporosis research
- Cardiovascular Function and Risk Factors
- Prostate Cancer Treatment and Research
- Liver Disease and Transplantation
- Diet and metabolism studies
- Hepatitis B Virus Studies
- Gout, Hyperuricemia, Uric Acid
- Cerebrovascular and Carotid Artery Diseases
- Atomic and Subatomic Physics Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Neuroimaging Techniques and Applications
- Atrial Fibrillation Management and Outcomes
University of Potsdam
2019-2025
German Agency for Quality in Medicine
2023-2024
University Hospital of Bern
2018
University of Bern
2018
Charité - Universitätsmedizin Berlin
2007-2017
Klinikum Ernst von Bergmann
2015-2017
Siemens (Germany)
2006-2014
Statistisches Bundesamt
2014
Robert Koch Institute
2011
Siemens Healthcare (Germany)
2009
To evaluate the safety and efficacy of gadoxetic acid disodium-enhanced magnetic resonance (MR) imaging for detection focal liver lesions, with results histopathologic examination and/or intraoperative ultrasonography used as a standard reference.One hundred sixty-nine patients who were known to have or suspected having lesions scheduled surgery included in this study. Results 131 could be analysis. MR was performed before immediately 20 minutes after bolus injection 0.025 mmol/kg...
PURPOSE: To detect hepatocyte-selective enhancement of focal lesions with gadoxetic acid at magnetic resonance (MR) imaging and to correlate in phases histopathologic findings arterial portal venous biphasic computed tomographic (CT) findings. MATERIALS AND METHODS: Study was supported by local ethics committee; all patients gave written informed consent. In 19 men 14 women recruited three clinical studies, correlation CT scans 41 (13 primary malignant lesions, 21 metastases, adenomas, cases...
Abstract The aim of this prospective study was to obtain the first human safety and magnetic resonance (MR) imaging results with a new formulation superparamagnetic iron oxide (SPIO) (SHU 555 A). SPIO tested at four doses, from 5 40 μmol/kg. Laboratory tests clinical measurements were done in 32 healthy volunteers for up 3 weeks after administration. MR 1.5 T performed before 8 hours 14 days fast intravenous injection (500 μmol Fe/min) (six subjects per dose). Results phase I demonstrate...
Objective: In our multi center trial we compared the potentials of biphasic contrast-enhanced computed tomography (CT) and a novel tissue-specific magnetic resonance imaging (MRI) contrast agent gadoxetic acid disodium in liver lesion characterization. Methods: A total 176 patients with 252 lesions were analyzed. There 104 malignant 148 benign lesions. High-field strength (1.0 T or 1.5 T) MR systems T1-and T2-weighted sequences used without fat suppression. After injection, dynamic...
To prospectively investigate the incremental value of multiparametric magnetic resonance (MR) imaging compared with standard T2-weighted for biopsy planning.The study was approved by institutional review board; informed consent obtained. Consecutive patients underwent supplemented 1.5-T MR imaging, consisting hydrogen 1 ((1)H) spectroscopy, diffusion-weighted (DW) and contrast material-enhanced imaging. Quantitative parameters were calculated: (choline plus creatine)-to-citrate ratio,...
The objective of our study was to prospectively evaluate quantitatively and qualitatively the enhancement patterns cirrhotic liver tissue hepatocellular carcinoma (HCC) after administration hepatocyte-specific contrast agent gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) on dynamic MRI determine time point maximum liver-to-lesion contrast.Twenty-five patients with HCC in cirrhosis underwent 1.5-T MRI. T2-weighted turbo spin-echo T1-weighted 3D gradient-echo...
Abstract Background This multicentre international randomized trial compared the impact of gadoxetic acid-enhanced magnetic resonance imaging (MRI), MRI with extracellular contrast medium (ECCM-MRI) and contrast-enhanced computed tomography (CE-CT) as a first-line method in patients suspected colorectal cancer liver metastases (CRCLM). Methods Between October 2008 September 2010, CRCLM were to one three modalities. The primary endpoint was proportion for whom further after initial required...
Heart failure (HF) is an imminent global health problem. Yet established screening algorithms for asymptomatic pre-HF, allowing early and effective preventive interventions, are largely lacking. The HERZCHECK trial, conducted in structurally underserved rural regions of North-Eastern Germany, aims to close this gap by evaluating the feasibility, diagnostic efficacy, cost-effectiveness a fully mobile, telemedically-supervised approach, combining cardiac magnetic resonance imaging (CMR)...
Liver-specific MRI is a fast-growing field, with technological and protocol advancements providing more robust imaging allowing greater depth of information per examination. This article reports the evidence for, expert thinking on, current challenges in liver-specific MRI, as discussed at 7th International Forum for Liver which was held Shanghai, China, October 2013.Topics included role gadoxetic acid-enhanced differentiation focal nodular hyperplasia from hepatocellular adenoma small...
Abstract Purpose: To compare enhancement of liver parenchyma in MR imaging after injection hepatocyte‐specific contrast media. Materials and Methods: Patients (n = 295) with known/suspected focal lesions randomly received 0.025 mmol gadoxetic acid/kg body weight or 0.05 gadobenate dimeglumine/kg by means bolus injection. was performed before immediately injection, the delayed phase at approved time points (20 min acid 40 dimeglumine). The relative for overall population a cirrhotic subgroup...
Purpose The purpose of this study was to evaluate the magnetic resonance prostate imaging reporting and data system (PI-RADS) for detection cancer by results (MRI)–guided biopsy as a reference standard. Patients Methods In 55 patients who had undergone MRI-guided prostate, we retrospectively matched every core with corresponding lesion in previously acquired endorectal multiparametric MRI including T2-weighted (T2WI), diffusion-weighted (DWI), dynamic contrast-enhanced (DCE-MRI) at 1.5 T....
Recent studies have demonstrated a superior diagnostic accuracy of cardiovascular magnetic resonance (CMR) for the detection coronary artery disease (CAD). We aimed to determine comparative cost-effectiveness CMR versus single-photon emission computed tomography (SPECT). Based on Bayes' theorem, mathematical model was developed compare and utility with SPECT in patients suspected CAD. Invasive angiography served as standard reference. Effectiveness defined accurate CAD, number...
Objectives: To evaluate gadofosveset trisodium for first-pass magnetic resonance angiography (MRA) in the setting of whole-body MRA (WB-MRA). Materials and Methods: Forty patients were examined using either 10 mL (n = 20) or 30 gadopentetate dimeglumine 20), followed by arterial-phase imaging 4 consecutive anatomic regions. Signal intensity was measured 2 vessels per region. Relative contrast values (RC) calculated. Arterial contrast, venous overlay, image quality rated radiologists. The...
This article reviews topics discussed during the Fifth International Forum for Liver MRI (with a focus on gadoxetic acid-enhanced MRI), which was held in Munich, Germany, September 2011.Growing evidence shows that has high sensitivity and specificity diagnosing liver tumors. Hepatobiliary phase imaging adds new information characterization of borderline lesions. However, there is need to develop standardized criteria interpretation patients with cirrhosis or other risk factors hepatocellular...
To evaluate whether magnetic resonance imaging (MRI) is effective as computed tomography (CT) in determining morphologic and functional pulmonary changes patients with cystic fibrosis (CF) association multiple clinical parameters.Institutional review board approval patient written informed consent were obtained. In this prospective study, 30 CF (17 men 13 women; mean (SD) age, 30.2 (9.2) years; range, 19-52 years) included. Chest CT was acquired by unenhanced low-dose technique for purposes....
The aim of the study was to compare radiation exposure and image quality between dedicated computed tomography (CT) protocols for preoperative total hip arthroplasty (THA) planning.Three with automated tube current modulation using 64-slice (n = 177) 128-slice CT scanners without 129) voltage preselection 84) were compared.All 390 CTs sufficient THA planning. Mean DLP 235.0 mGy*cm (effective dose 2.8 mSv). Lowest (2.5 mSv) seen algorithm's selection 100 kV (90.5% patients) 120 kV. noise in...
The hypothesis for this prospective study was that T1-weighted respiratory triggered high spatial resolution images of the liver acquired during uptake phase a hepatobiliary contrast medium are technically feasible and provide significantly improved image quality compared with breath-hold images.An inversion recovery-prepared spoiled gradient echo sequence developed can be obtained triggering. This in 20 patients total 41 focal lesions axial coronal sequences. All 3 sequences were after...