A5022679280- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Lanthanide and Transition Metal Complexes
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Photoacoustic and Ultrasonic Imaging
- Cerebrovascular and Carotid Artery Diseases
- Atomic and Subatomic Physics Research
- Radiation Dose and Imaging
- Ultrasound and Hyperthermia Applications
- Lysosomal Storage Disorders Research
- Pancreatic and Hepatic Oncology Research
- Peripheral Artery Disease Management
- Shoulder Injury and Treatment
- Liver Disease Diagnosis and Treatment
- Powder Metallurgy Techniques and Materials
- Infrared Thermography in Medicine
- Electron Spin Resonance Studies
- Medical Imaging Techniques and Applications
- Advanced Sensor Technologies Research
- Trypanosoma species research and implications
- Skin Protection and Aging
- Cardiomyopathy and Myosin Studies
Bayer (Germany)
2022-2023
University of Wisconsin–Madison
2017-2022
Charité - Universitätsmedizin Berlin
2009-2020
Humboldt-Universität zu Berlin
2010
Heidelberg University
1971
Objectives The aim of this study was to determine the relaxation properties ferumoxytol, an off-label alternative gadolinium-based contrast agents, under physiological conditions at 1.5 T and 3.0 T. Materials Methods Ferumoxytol diluted in gradually increasing concentrations (0.26–4.2 mM) saline, human plasma, whole blood. Magnetic resonance relaxometry performed 37°C Longitudinal transverse rate constants (R1, R2, R2*) were measured as a function ferumoxytol concentration, relaxivities (r1,...
To evaluate the diagnostic performance of susceptibility-weighted imaging (SWI) and standard shoulder joint magnetic resonance (MR) sequences in comparison to that conventional radiography for identification calcifications rotator cuff patients with calcific tendonitis.The institutional review board approved this prospective study. Written informed consent was obtained from all subjects. Fifty-four clinically suspected having tendonitis were included. On radiographs (the reference), 27 had...
To demonstrate non-inferiority of iobitridol 350 for coronary CT angiography (CTA) compared to higher iodine content contrast media regarding rate patients evaluable the presence artery stenoses. In this multicentre trial, 452 were randomized receive 350, iopromide 370 or iomeprol 400 and underwent CTA using systems with 64-detector rows more. Two core lab readers assessed 18 segments per patient image quality (score 0 = non diagnostic 4 excellent quality), vascular attenuation, signal noise...
Determine the impact of microscopic spatial distribution iron on relaxometry and susceptibility-based estimates concentration.Monte Carlo simulations in vitro experiments erythrocytes were used to create different distributions iron. Measuring with intact erythrocyte cells created a heterogeneous iron, whereas lysing was homogeneous Multi-echo spin echo spoiled gradient acquisitions then estimate relaxation parameters ( R2 R2* ) susceptibility.Simulations demonstrate that measurements depend...
Purpose To evaluate the feasibility of ferumoxytol (FE)‐enhanced UTE‐MRA for depiction pulmonary vascular and nonvascular structures. Methods Twenty healthy volunteers underwent contrast‐enhanced MRA at 3 T during 2 visits, separated by least 4 weeks. Visit 1: The started with a conventional multiphase 3D 1 ‐weighted breath‐held spoiled gradient‐echo before after injection 0.1 mmol/kg gadobenate dimeglumine (GD). Subsequently, free‐breathing GD‐UTE‐MRA was acquired as series flip angles...
Background Anderson-Fabry disease (AFD) is an X-linked lysosomal enzyme disorder associated with intracellular accumulation of sphingolipids, which shorten myocardial T1 relaxation times. Myocardial affection, however, varies between different segments. Purpose To evaluate the specific segmental distribution and degree affection in AFD patients. Material Methods Twenty-five patients AFD, 14 hypertrophic cardiomyopathy (HCM), 21 controls were included. A Modified Look-Locker Inversion...
To compare cost offsets and contributing factors (false-negative rates confirmatory imaging requirements, potentially leading to longer waiting times for diagnosis) as well long-term effectiveness associated with the diagnostic treatment pathways colorectal cancer liver metastases (CRCLM) in US, Japan, China according initial modality used. Gadoxetate disodium (ethoxylbenzyl-diethylenetriaminepentaacetic acid)-enhanced magnetic resonance (EOB-MRI) was compared multidetector computed...
Purpose Cerebral perfusion is commonly assessed clinically with dynamic susceptibility contrast MRI using a bolus injection of gadolinium‐based agents, resulting in semi‐quantitative values cerebral blood volume (CBV). Steady‐state imaging ferumoxytol allows estimation CBV the potential for higher precision and accuracy. Prior studies have focused on signal disrupting effects, but also has high signal‐enhancing T 1 relaxivity. The purpose this study was to investigate compare , goal...
Objectives The signal enhancement (SE) and kinetics of gadolinium-based contrast agents (GBCAs) in T1-weighted magnetic resonance (MR) images depend on the relaxivity GBCA its pharmacokinetic profile. This vivo study systematically compared SE (technical efficacy) 3 macrocyclic GBCAs gadobutrol, gadoteridol, gadoterate meglumine various body regions. Materials Methods A total 15 healthy male white New Zealand rabbits were randomly divided into groups (n = 5/group). injected intravenously...
To compare relative costs associated with the diagnostic pathways for hepatocellular carcinoma (HCC) in US and China according to initial imaging modality used. Gadoxetate disodium (ethoxylbenzyl-diethylenetriaminepentaacetic acid)-enhanced magnetic resonance (EOB-MRI) was compared contrast-enhanced multidetector computed tomography (MDCT), extracellular contrast media enhanced-MRI (ECCM-MRI) ultrasound (CEUS).Decision tree models were developed simulate clinical pathway, based on local...