A5027386555- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Radiation Dose and Imaging
- Advanced NMR Techniques and Applications
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Ultrasound in Clinical Applications
- Advanced Neuroimaging Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Quantum, superfluid, helium dynamics
- Congenital Diaphragmatic Hernia Studies
- Ion channel regulation and function
- Ultrasound and Hyperthermia Applications
- Hemoglobinopathies and Related Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lanthanide and Transition Metal Complexes
- Hepatocellular Carcinoma Treatment and Prognosis
- Acute Ischemic Stroke Management
- Cystic Fibrosis Research Advances
- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
University of Wisconsin–Madison
2015-2024
Wisconsin Institutes for Discovery
2018-2021
Madison County Public Schools
2017
Vertex Pharmaceuticals (United States)
2017
University of Iowa
2016
University of Southern California
2016
Pediatrics and Genetics
2014
Wisconsin Division of Public Health
2013
Highland Community College - Illinois
2012
Stanford University
2007
BACKGROUND. The link between mucus plugs and airflow obstruction has not been established in chronic severe asthma, the role of eosinophils their products plug formation is unknown.
Purpose To optimize 3D radial ultrashort echo time MRI for high resolution whole‐lung imaging. Methods was implemented on a 3T scanner to investigate the effects of: (1) limited field‐of‐view excitation, (2) variable density readouts, and (3) oversampling. Improvements in noise performance spatial were assessed through simulation phantom studies. Their lung airway visualization five healthy male human subjects (mean age 32 years) compared qualitatively blinded ordinal scoring by two...
MscL is a channel that opens large pore in the Escherichia coli cytoplasmic membrane response to mechanical stress. Previously, we highly enriched protein by using patch clamp as functional assay and cloned corresponding gene. The predicted contains largely hydrophobic core spanning two-thirds of molecule more hydrophilic carboxyl terminal tail. Because had no homology characterized proteins, it was impossible predict regions simple inspection. Here, mutagenesis, have searched for...
Abstract Geometric distortions and poor image resolution are well known shortcomings of single‐shot echo‐planar imaging (ss‐EPI). Yet, due to the motion immunity ss‐EPI, it remains most common sequence for diffusion‐weighted (DWI). Moreover, both navigated DW interleaved EPI (iEPI) parallel (PI) methods, such as sensitivity encoding (SENSE) generalized autocalibrating acquisitions (GRAPPA), can improve quality in EPI. In this work, DW‐EPI accelerated by PI is proposed a self‐calibrated...
To investigate the utility of a free-breathing ultrashort echo time (UTE) sequence for evaluation small pulmonary nodules in oncology patients by using hybrid positron emission tomography (PET)/magnetic resonance (MR) imaging system and to compare nodule detection rate between UTE conventional three-dimensional gradient-recalled-echo (GRE) technique.In this HIPAA-compliant, institutional review board-approved prospective study, 82 were identified eight with extrathoracic malignancies....
The structural gene for diphtheria toxin, tox, has been modified at its Sph I site by the introduction of an oligonucleotide linker encoding a unique Pst restriction endonuclease and synthetic alpha-melanocyte-stimulating hormone (alpha-MSH). resulting fusion directs expression toxin-related alpha-MSH hybrid protein in which toxin receptor-binding domain replaced with sequences. chimeric partially purified from periplasmic extracts recombinant Escherichia coli K-12 found to be selectively...
Purpose To determine the effectiveness of MR angiography for pulmonary embolism (MRA‐PE) in symptomatic patients. Materials and Methods We retrospectively reviewed all patients whom were evaluated possible (PE) using MRA‐PE. A 3‐month 1‐year from MRA‐PE electronic medical record (EMR) review was performed. Evidence venous thromboembolism (VTE) (or death PE) within year follow‐up outcome surrogate this study. Results There 190 exams performed with 97.4% (185/190) diagnostic quality. 148 (120...
Purpose To achieve motion robust high resolution 3D free‐breathing pulmonary MRI utilizing a novel dynamic image navigator derived directly from imaging data. Methods Five‐minute scans were acquired with ultrashort echo time (UTE) sequence 1.25 mm isotropic resolution. From this data, self‐navigating images reconstructed under locally low rank (LLR) constraints and used for compensation one of two methods: soft‐gating technique to penalize the respiratory induced data inconsistency,...
The purpose of this work was to use 3D radial ultrashort echo time (UTE) MRI perform whole‐lung oxygen‐enhanced (OE) imaging in humans. Eight healthy human subjects underwent two UTE acquisitions ( T E = 0.08 ms): one while breathing 21% O 2 and the other 100% . Scans were each performed over 5 min free breathing, using prospective respiratory gating. For comparison purposes, conventional 2.1 ms) images acquired simultaneously during acquisition a " outward‐inward" k ‐space trajectory....
Background A previous study demonstrated the feasibility of using 3D radial ultrashort echo time (UTE) oxygen‐enhanced MRI (UTE OE‐MRI) for functional imaging healthy human lungs. The repeatability quantitative measures from UTE OE‐MRI needs to be established prior its application in clinical research. Purpose To evaluate obstructive patterns asthma and cystic fibrosis (CF) with isotropic spatial resolution full chest coverage. Study Type Volunteer patient repeatability. Population Eighteen...
Abstract Purpose: To evaluate the signal to noise ratio (SNR) and contrast (CNR) performance of 0.05 mmol/kg gadoxetic acid 0.1 gadobenate dimeglumine for dynamic hepatobiliary phase imaging. In addition, flip angles (FA) that maximize relative contrast‐to‐noise imaging were determined. Materials Methods: A cross‐over study in 10 volunteers was performed using each agent. Imaging at 3 Tesla (T) with a 32‐channel phased‐array coil breathheld 3D spoiled gradient echo sequences SNR CNR...
Abstract Purpose: To determine optimal delay times and flip angles for T1‐weighted hepatobiliary imaging at 1.5 Tesla (T) with gadoxetic acid to demonstrate the feasibility of using a high‐resolution navigated optimized pulse sequence evaluate biliary disease. Materials Methods: Eight healthy volunteers were scanned 1.5T three‐dimensional (3D)‐SPGR following administration 0.05 mmol/kg acid. Navigator‐gating enabled acquisition high spatial resolution (1.2 × 1.4 1.8 mm 3 , interpolated 0.7...
Purpose To investigate the utility of hyperpolarized He-3 MRI for detecting regional lung ventilated volume (VV) changes in response to exercise challenge and leukotriene inhibitor montelukast, human subjects with induced bronchoconstriction (EIB) were recruited. This condition is described by airway constriction following leading reduced forced expiratory 1 second (FEV1) coinciding ventilation defects on MRI. Materials Methods Thirteen EIB underwent spirometry at baseline, postexercise,...
Background Airway mucus plugs in asthma are associated with exacerbation frequency, increased eosinophilia, and reduced lung function. The relationship between spatially overlapping ventilation abnormalities observed at hyperpolarized gas MRI has not been assessed quantitatively. Purpose To assess regional associations CT scored by individual bronchopulmonary segment corresponding measurements of segmental defect percentage (VDP) helium 3 (3He) MRI. Materials Methods In this secondary...
Abstract The γ chain compositions of the fetal hemoglobins 2453 newborn babies from East Asian countries (1350 babies), Italy, Yugoslavia, Bulgaria, and Georgia (417 Caucasian 686 black were determined by high pressure liquid chromatography. Unusual results for a limited number confirmed chemical analyses, evaluated further family studies. Statistical analyses indicated gene frequencies A T in Italian (f = 0.237), Yugoslavian Bulgarian 0.238), white 0.224), lower frequency Japan 0.178),...
To quantitatively evaluate interday, interreader, and intersite agreement of readers hyperpolarized helium 3 (HPHe) MR images in patients with exercise-induced bronchoconstriction.This HIPAA-compliant, institutional review board approved study included 13 bronchoconstriction. On two separate days, HPHe imaging the lungs was performed at baseline, immediately after a 10-minute exercise challenge (postchallenge), 45 minutes (recovery). Patients were imaged sites, six site A seven B. Images...
Abstract Purpose: To investigate the value of gadoxetic acid‐enhanced three‐dimensional T1‐weighted MR cholangiography (T1w‐MRC) in comparison to T2‐weighted cholangiopancreaticography (T2w‐MRCP) patients with primary sclerosing cholangitis (PSC). Materials and Methods: Thirty‐four exams 29 (46.0 ± 16.1 years; 19 men, 10 women) scanned within a 14‐month period were retrospectively included. Two abdominal radiologists independently evaluated image quality regarding contrast, degradation due...