A5058992644- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Urticaria and Related Conditions
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Respiratory Support and Mechanisms
- Autoimmune Bullous Skin Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Voice and Speech Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- COVID-19 Clinical Research Studies
- Healthcare Systems and Technology
- Sleep and related disorders
- Chronic Disease Management Strategies
- Pulmonary Hypertension Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- IgG4-Related and Inflammatory Diseases
- Venous Thromboembolism Diagnosis and Management
- Autoimmune and Inflammatory Disorders
St. Vincent's University Hospital
2018-2024
University College Dublin
2018-2024
University of Wisconsin–Madison
2021
University of California, San Francisco
2015-2018
Cardiovascular Institute Hospital
2018
University of California System
2016
Pulmonary and Critical Care Associates
2015
Botsford Hospital
2014
Beaumont Hospital, Dearborn
2014
Beaumont Hospital
2010-2011
BACKGROUND. The link between mucus plugs and airflow obstruction has not been established in chronic severe asthma, the role of eosinophils their products plug formation is unknown.
A thiol-modified carbohydrate compound treats pathologic mucus gel formation in inflamed airways.
Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are implicated in multiple inflammatory diseases. NETs mediate inflammasome activation IL-1β secretion from monocytes cause airway epithelial cell injury, but the role of eDNA, NETs, asthma is uncertain.
Neutrophil cytoplasts promote T H 17 inflammation.
Cross-sectional analysis of mucus plugs in computed tomography (CT) lung scans the Severe Asthma Research Program (SARP)-3 showed a high plug phenotype.
Definition of abbreviation: n/a = not available.Asthma was diagnosed by either methacholine hyperresponsiveness or bronchodilator responsiveness.*Age, body mass index, and spirometry data are presented as mean 6 SD.† Sputum cell count is the median (range).
Rationale: The relative roles of mucus plugs and emphysema in mechanisms airflow limitation hypoxemia smokers with chronic obstructive pulmonary disease (COPD) are uncertain.Objectives: To relate image-based measures to obstruction oxygenation patients COPD.Methods: We analyzed computed tomographic (CT) lung images function participants the Subpopulations Intermediate Outcome Measures COPD Study. Radiologists scored on CT images, imaging software automatically quantified percentage....
Rationale: Loss of the peripheral pulmonary vasculature, termed vascular pruning, is associated with disease severity in patients chronic obstructive disease.Objectives: To determine if pruning asthma and exacerbations.Methods: We measured total blood vessel volume (TBV) vessels less than 5 mm2 cross-sectional area (BV5) 10 (BV10) on noncontrast computed tomographic scans participants from Severe Asthma Research Program. Lower values BV5 to TBV ratio (BV5/TBV) BV10 (BV10/TBV) represented...
Abstract By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives formation pathologic mucus which leads to airway plugging. Here we investigate molecular role and clinical significance intelectin-1 (ITLN-1) development asthma. Through analyses human epithelial cells find that ITLN1 gene expression is highly induced by interleukin-13 (IL-13) a subset metaplastic MUC5AC + secretory cells, ITLN-1 protein secreted component IL-13-induced...
Background Airway mucus plugs in asthma are associated with exacerbation frequency, increased eosinophilia, and reduced lung function. The relationship between spatially overlapping ventilation abnormalities observed at hyperpolarized gas MRI has not been assessed quantitatively. Purpose To assess regional associations CT scored by individual bronchopulmonary segment corresponding measurements of segmental defect percentage (VDP) helium 3 (3He) MRI. Materials Methods In this secondary...
Density thresholds in computed tomography (CT) lung scans quantify air trapping (AT) at the whole-lung level but are not informative for AT specific bronchopulmonary segments.
Extrapulmonary manifestations of asthma, including fatty infiltration in tissues, may reflect systemic inflammation and influence lung function disease severity.
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder occurring in response to Aspergillus fumigatus that can complicate the course of asthma and cystic fibrosis. Here we present case acute ABPA without central bronchiectasis, chronic active with severe relapsing bronchiectasis. All three were initially treated corticosteroids antifungal agents but had an incomplete response. These patients then anti-IgE therapy omalizumab before being switched anti-IL5R agent benralizumab....
<h3>Introduction</h3> Mucus hypersecretion resulting from type 2 cytokines (e.g., interleukin [IL]-13) drives intermittent airway obstruction and remodeling. Dupilumab blocks the shared receptor component for IL-4/IL-13, improved lung function, reduces rates of severe exacerbations in patients (≥12 years) with moderate-to-severe asthma up to 3 years, or years children (6–11 years). The VESTIGE study (NCT04400318) assessed dupilumab's impact on mucus plugging, volume, inflammation, related...