A5071453912- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Nutrition and Health in Aging
- Cancer Immunotherapy and Biomarkers
- Respiratory Support and Mechanisms
- Cancer Treatment and Pharmacology
- Cutaneous Melanoma Detection and Management
- Cell death mechanisms and regulation
- Inhalation and Respiratory Drug Delivery
- Colorectal Cancer Treatments and Studies
- Smoking Behavior and Cessation
- Clinical Nutrition and Gastroenterology
- Body Composition Measurement Techniques
- Renal and related cancers
- Antifungal resistance and susceptibility
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- BRCA gene mutations in cancer
- Acute Myeloid Leukemia Research
- Frailty in Older Adults
- Non-Invasive Vital Sign Monitoring
- Oral health in cancer treatment
- Lung Cancer Treatments and Mutations
- Family and Patient Care in Intensive Care Units
- Bacteriophages and microbial interactions
St. Vincent's University Hospital
2017-2021
Beaumont Hospital
2014-2021
University College Dublin
2020-2021
Tallaght University Hospital
2017-2018
University Hospital Galway
2015
Mercy University Hospital
2014
Bon Secours Hospital Cork
2011
University College Cork
2011
Ollscoil na Gaillimhe – University of Galway
2008-2010
McMaster University
1987
The crystal structure of the 93-K superconductor ${\mathrm{YBa}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7}$ has been elucidated from neutron powder diffraction data at 298 and 79.5 K. We confirm basic features perovskite-related found room temperature earlier x-ray studies small single crystals find, additionally, that ordering one oxygen atoms gives rise to square planar coordination for copper rather than disordered octahedral coordination. Within resolution our there is no apparent change...
Abstract New therapeutic approaches aim to eradicate tumours by expression of tumouricidal proteins in the tumour stroma. One such anti‐neoplastic protein is necrosis factor‐related apoptosis‐inducing ligand (TRAIL) because it induces apoptosis cancerous cells, but not non‐transformed cells. Stem cells can migrate to, survive and proliferate tumours. We examined suitability bone marrow‐derived adult mesenchymal stem (bmMSC), foetal‐MSC umbilical cord matrix (Wharton’s Jelly MSCs) as...
The p53 protein is a sequence-specific DNA-binding factor that regulates inflammatory genes such as CCL2/MCP-1 may play role in various diseases. A recent study has indicated the knockdown of human leads to strong negative regulation CCL2 induction. We are therefore interested how gene expression. In following study, our findings indicate UV-induced accumulation mouse macrophages significantly decreases LPS-induced production, and binds 5'UTR region (16-35). also found domain (p53pep170)...
Abstract Despite progress in the treatment of acute myelogenous leukaemia (AML) outcome often remains poor. Tumour necrosis factor related apoptosis‐inducing ligand (TRAIL) is a promising therapeutic agent many different types tumours, but AML cells are relatively insensitive to TRAIL‐induced apoptosis. Here we show that apoptosis predominantly mediated by death receptor 4 (DR4) and not DR5. Therefore, constructed variant TRAIL (rhTRAIL‐C3) strong inducer DR4‐mediated TRAIL‐C3 demonstrated...
The potential of immunoassays as high-throughput screening tools for the detection harmful substances in foods will only be realized when convenient methods are available production high affinity antibodies needed sensitive assay development. Recombinant offer advantages over traditional monoclonal terms ease production, much greater antibody repertoire selection, and versatility. We describe here development recombinant against common shellfish toxin, domoic acid (DA), utilizing sheep...
Asthma is a common condition and there remains subset of patients who are poorly controlled on maximal therapy. Bronchial thermoplasty (BT) bronchoscopic therapy using radiofrequency energy to reduce airway smooth muscle, which has been shown improve asthma control although further evidence regarding long-term efficacy safety required.We aimed demonstrate BT extended follow-up. Our initial experience with this group was previously reported in 2016, where were have significant improvement...
Abnormal and prolonged inflammatory reaction is seen in a wide variety of disorders, high level Tumor Necrosis Factor alpha (TNF-α) has been linked to these disorders. Therefore, modulation TNF-α expression important the regulation In our previous study, we have shown that transcription factor LPS-induced TNF (LITAF) significantly induces production. Furthermore, found p53 its synthetic peptide 162-motif specifically downregulate LITAF/TNF-α gene human cells vitro. Thus, present role...
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder occurring in response to Aspergillus fumigatus that can complicate the course of asthma and cystic fibrosis. Here we present case acute ABPA without central bronchiectasis, chronic active with severe relapsing bronchiectasis. All three were initially treated corticosteroids antifungal agents but had an incomplete response. These patients then anti-IgE therapy omalizumab before being switched anti-IL5R agent benralizumab....
The EvidenzerIRL instrument has been in use as an evidential breath analyser the application of drink driving laws Republic Ireland since 2011. result analysis is used evidence prosecutions before Courts per se offences under influence alcohol distinct from screening results at roadside. This study aims to assist doctors, lawyers and judges assessing drivers' failure provide valid specimens. Since introduction EvidenzerIRL, approximately 10% tests annually or refusal a successful specimen,...
In the enforcement of drink driving laws failing to provide a breath specimen for alcohol analysis at roadside when requested by Police Officer is an offence in many countries. Some drivers claim that lung disease prevented their ability be successful. This study aims investigate relationship between presence and successful using Dräger 6510 screening device. Sixty participants with nineteen control underwent pulmonary function tests were then tested Only one participant was unsuccessful...
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617 Background: The use of novel targeted therapies is becoming increasingly prevalent. This study aimed to determine how novel- have changed the profile dermatological toxicity in patients being treated for colorectal carcinoma. Methods: Retrospective analysis was performed a single institution all presenting over period 4 weeks. Participants were followed up remainder period. Patient charts reviewed previou incidences toxicity. Toxicity graded using Common Criteria version 3. Statistical...
e19659 Background: This study aimed to determine how increased use of novel targeted therapies (NTT) has changed the profile dermatological toxicity in oncology day units. Methods: Retrospective analysis was performed a single institution for all patients presenting over four week period. Participants were followed up remainder Patient charts reviewed incidences toxicity. Toxicity graded using CTCv3. Statistical SPSSv18. Results: A total 135 presented, 116 underwent final analysis. 59...
The Draeger 6510 and the EvidenzerIRL devices are currently in use Ireland for roadside screening evidential breath testing respectively. purpose of this study was to determine whether presence severity lung disease influences ability provide a sufficient specimen alcohol analysis using both devices. Subjects were recruited opportunistically when having pulmonary function tests clinical purposes. Of 61 adult subjects studied 21 had Chronic Obstructive Lung Disease (COPD), Interstitial (ILD)...
<h3>Introduction</h3> The Working Backs Programme (WBP) is designed for staff reporting back pain as a result of work or whose performance affected. It's comprehensive approach including medical assessment, provision information and education, designated physiotherapy ergonomic referral service pathway further investigations and/or review. effectiveness was evaluated by an initial audit in 2012 subsequent audits 2015 2016. <h3>Methods</h3> Data collected through questionnaires at...