Colleen Reilly
A5010065681- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- BRCA gene mutations in cancer
- Genomics and Rare Diseases
- Cancer-related cognitive impairment studies
- CAR-T cell therapy research
- Single-cell and spatial transcriptomics
- Health, Environment, Cognitive Aging
- Cardiovascular Function and Risk Factors
- Diabetic Foot Ulcer Assessment and Management
- COVID-19 and healthcare impacts
- Sarcoma Diagnosis and Treatment
- Chronic Disease Management Strategies
- Genetics and Neurodevelopmental Disorders
- Electron Spin Resonance Studies
- Mitochondrial Function and Pathology
- Cancer survivorship and care
- Neuroblastoma Research and Treatments
- Biochemical and Molecular Research
- Acute Myeloid Leukemia Research
- Bioinformatics and Genomic Networks
- Genomics and Chromatin Dynamics
- Immune cells in cancer
- Complementary and Alternative Medicine Studies
- Folate and B Vitamins Research
St. Jude Children's Research Hospital
2021-2025
Weatherford College
2024
Disco (Germany)
2024
University of Tennessee Health Science Center
2021
University of Kansas
2017
University of Maryland, Baltimore
2014
Beaumont Hospital
2014
Portland Cement Association
1911
Retinoblastoma is a childhood cancer of the developing retina that initiates with biallelic inactivation RB1 gene. Children germline mutations in have high likelihood retinoblastoma and other malignancies later life. Genetically engineered mouse models share some similarities human but there are differences their cellular differentiation. To develop laboratory model formation, we make induced pluripotent stem cells (iPSCs) from 15 participants mutations. Each cell lines validated,...
SUMMARY Neuroblastoma is a pediatric cancer arising from the developing sympathoadrenal lineage with complex inter- and intra-tumoral heterogeneity. To chart this complexity, we generated comprehensive cell atlas of 55 neuroblastoma patient tumors, collected two institutions, spanning range clinical, genetic, histologic features. Our combines single-cell/nucleus RNA-seq (sc/scRNA-seq), bulk RNA-seq, whole exome sequencing, DNA methylation profiling, spatial transcriptomics, proteomic...
Abstract Childhood cancer survivorship studies generate comprehensive datasets comprising demographic, diagnosis, treatment, outcome, and genomic data from survivors. To broadly share this data, we created the St. Jude Survivorship Portal (https://survivorship.stjude.cloud), first portal for sharing, analyzing, visualizing pediatric data. More than 1,600 phenotypic variables 400 million genetic variants more 7,700 childhood survivors can be explored on free, open-access portal. Summary...
Abstract Medulloblastoma (MB) is one of the most malignant pediatric brain tumors. Molecularly, MB separates into four subgroups—WNT, SHH, Group 3 (G3), and 4 (G4)—each with unique clinical features genetic profiles. WNT tumors have best survival outcomes low metastatic potential, whereas G3 exhibit highest malignancy poorest outcomes. While SHH are highly distinct, G4 interrelated when grouped together, these referred to as G3/G4 These genetically complex, a constellation molecular...
The purpose of this study was to examine patterns and predictors complementary alternative medicine (CAM) among breast cancer patients. A review the existing survey literature on CAM use for conducted with a series eight focus groups (N = 67) further perspectives patients CAM. rates varied from 17 75%, mean 45%. Vitamins minerals herbs were most frequently cited categories. Users tended be younger, more educated, likely have used prior their diagnosis. Focus group data indicate that wide...
Malignant peripheral nerve sheath tumor (MPNST), a highly aggressive Schwann cell (SC)–derived soft tissue sarcoma, arises from benign neurofibroma (NF); however, the identity, heterogeneity and origins of populations remain elusive. Nestin + cells have been implicated as stem in MPNST; unexpectedly, single-cell profiling human NF MPNST their animal models reveal broad range nestin-expressing SC lineage dynamic acquisition discrete cancer states during malignant transformation. We uncover...
Abstract Survivors of childhood cancer are at risk for developing various adverse health conditions as adults that attributable to the and treatments they were exposed children. Cancer survivorship research relies on large-scale, longitudinal studies generate a wide range demographic, clinical, genetic data survivors. Nevertheless, absence portals has made it challenging broadly share data. We have created St. Jude Survivorship Portal (https://survivorship.stjude.cloud), first portal...
<p>Workflow for building custom groups</p>
<p>Association between ARID5B variants and ALL in African European ancestries</p>
<p>Ototoxicity of platinum-based chemotherapy in the CCSS cohort</p>
<p>Supplementary Notes</p>
<p>Exporting data for haplotype analysis</p>
<p>Workflow for building custom groups</p>
<p>User interface for genetic association analysis on the portal</p>
<p>Ototoxicity of platinum-based chemotherapy in the CCSS cohort</p>
<p>Association between ARID5B variants and ALL in African European ancestries</p>