A5003715754- Cancer-related molecular mechanisms research
- Diabetes and associated disorders
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- RNA modifications and cancer
- Hepatitis C virus research
- Virology and Viral Diseases
- Diabetes Management and Research
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Gene expression and cancer classification
- Ferroptosis and cancer prognosis
- Diet and metabolism studies
- Childhood Cancer Survivors' Quality of Life
- Metabolomics and Mass Spectrometry Studies
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Respiratory viral infections research
- Birth, Development, and Health
- Cancer, Hypoxia, and Metabolism
- Immune responses and vaccinations
- COVID-19 Clinical Research Studies
- Hepatitis Viruses Studies and Epidemiology
Fudan University
2016-2025
St. Jude Children's Research Hospital
2022-2025
Hangzhou Medical College
2018-2025
Zhejiang Provincial People's Hospital
2018-2025
Yangzhou University
2022-2025
Third Hospital of Hebei Medical University
2022-2025
Hebei Medical University
2022-2025
Zhongshan Hospital
2016-2025
Beijing Center for Disease Prevention and Control
2017-2025
Yunnan Agricultural University
2025
The basic reproduction number of an infectious agent is the average infections one case can generate over course period, in a naïve, uninfected population. It well-known that estimation this may vary due to several methodological issues, including different assumptions and choice parameters, utilized models, used datasets period. With spreading novel coronavirus (2019-nCoV) infection, has been found vary, reflecting dynamics transmission outbreak as well reporting rate. Due significant...
Abstract Background Mango is one of the world’s most important tropical fruits. It belongs to family Anacardiaceae, which includes several other economically species, notably cashew, sumac and pistachio from genera. Many species in this produce family-specific urushiols related phenols, can induce contact dermatitis. Results We generate a chromosome-scale genome assembly mango, providing reference for Anacardiaceae family. Our results indicate occurrence recent whole-genome duplication (WGD)...
Abstract ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein. It exists as a free molecule, intracellularly and extracellularly, conjugated to target proteins. Studies in mice have demonstrated role for Isg15 antiviral immunity. By contrast, human was shown critical immune functions, but not Namely, extracellular crucial IFN-γ-dependent antimycobacterial immunity, while intracellular USP18-mediated downregulation of IFN-α/β signalling. Here we describe -deficient patients who...
Following acute infection, individuals COVID-19 may still shed SARS-CoV-2 RNA. However, limited information is available regarding the active shedding period or whether infectious virus also shed. Here, we monitored clinical characteristics and virological features of 38 patients with (long-term carriers) who recovered from disease, but viral RNA for over 3 months. The median carrying history long-term carriers was 92 days after first admission, longest 118 days. Negative-positive...
The aim of this study was to evaluate the long-term effects lithium treatment on neonatal hypoxic-ischemic brain injury, inflammation, and neural stem/progenitor cell (NSPC) proliferation survival. Nine-day-old male rats were subjected unilateral hypoxia–ischemia (HI) 2 mmol/kg chloride injected intraperitoneally immediately after insult. Additional injections, 1 mmol/kg, administered at 24-hour intervals for 7 days. Animals killed 6, 24, 72 hours, or weeks HI. Lithium reduced total tissue...
Normalization of RNA-Seq data has proven essential to ensure accurate inferences and replication findings. Hence, various normalization methods have been proposed for technical artifacts that can be present in high-throughput sequencing transcriptomic studies. In this study, we set out compare the widely used library size (UQ, TMM, RLE) across sample (SVA, RUV, PCA) using publicly available from The Cancer Genome Atlas (TCGA) cervical cancer study. Additionally, an extensive simulation study...
Abstract Maternal dietary patterns and macronutrients intake have been shown to affect the development of gestational diabetes mellitus (GDM), but findings are inconsistent. We aimed identify maternal examine their associations with GDM risk, evaluate contributions these associations. included 2755 Chinese pregnant women from Tongji Child Health Cohort. Dietary intakes were assessed using a validated semi-quantitative FFQ 2 weeks before diagnosis GDM. ( n 248) was diagnosed based on results...
Brucellosis has extensive clinical spectrum, clinicians have insufficient understanding of the disease, and misdiagnosis rate is still high. By collecting analyzing characteristics patients with brucellosis in Heilongjiang Province to provide guidance reference for make timely diagnosis treatment.The demographic epidemiological characteristics, features, complications, laboratory findings were retrospectively evaluated 850 admitted Department Infectious Diseases First Affiliated Hospital...
Schizophrenia (SCZ) is associated with several immune dysfunctions, including elevated levels of pro-inflammatory cytokines. Microorganisms and their metabolites have been found to regulate the system, that intestinal microbiota significantly disturbed in schizophrenic patients. To systematically investigate aberrant gut-metabolome-immune network schizophrenia, we performed an integrative analysis microbiota, serum metabolome, inflammatory cytokines 63 SCZ patients 57 healthy controls using...
Children at increased genetic risk for type 1 diabetes (T1D) after environmental exposures may develop pancreatic islet autoantibodies (IA) a very young age. Metabolic profile changes over time imply responses to and signal development of the first IA. Our present research in The Environmental Determinants Diabetes Young (TEDDY) study aimed identify metabolome-wide signals preceding IA against GAD (GADA-first) or insulin (IAA-first). We profiled metabolomes by mass spectrometry from...
Breast cancer patients with high proportion of stem cells (BCSCs) have unfavorable clinical outcomes. MicroRNAs (miRNAs) regulate key features BCSCs. We hypothesized that a biology-driven model based on BCSC-associated miRNAs could predict prognosis for the most common subtype, hormone receptor (HR)-positive, HER2-negative breast patients.After screening candidate literature review and pilot study, we built miRNA-based classifier using LASSO Cox regression method in training group (n=202)...
The association between iron supplementation and gestational diabetes mellitus (GDM) is still inconclusive, this has not been extensively studied in relation to plasma ferritin the early second trimester. We aimed prospectively examine independent combined associations of concentrations supplement use with GDM. 2117 women from Tongji Maternal Child Health Cohort Wuhan, China. Plasma around 16 weeks' gestation was measured by ELISA kits information on collected questionnaires. GDM diagnosed a...
INTRODUCTION: The Environmental Determinants of Diabetes in the Young study follows an HLA risk selected birth cohort for celiac disease (CD) development using a uniform protocol. Children under investigation come from 6 different regions within Europe and United States. Our aim was to identify regional differences CD autoimmunity cumulative incidence children born between 2004 2010. METHODS: (n = 6,628) with DQ2.5 and/or DQ8.1 were enrolled prospectively Georgia, Washington, Colorado,...
Abstract Alcohol consumption during pregnancy can result in a range of adverse postnatal outcomes among exposed children. However, identifying at-risk children is challenging given the difficulty to confirm prenatal alcohol exposure and lack early diagnostic tools. Placental surveys present an important opportunity uncover biomarkers identify those at risk. Here, we report first transcriptome-wide evaluation comprehensively evaluate human placental pathways altered by fetal exposure. In...
BackgroundThe reported coverage rates of first and second doses measles containing vaccine (MCV) are almost 95% in China, while cases constantly being reported. This study evaluated the coverage, timeliness, barriers to immunization MCV1 MCV2 children aged from 8–48 months. MethodsWe assessed 718 months, which 499 18–48 months September 2011. Face face interviews were administered with children's mothers estimate rate, its timeliness uptake. ResultsThe 76.9% for 44.7% average. Only 47.5%...