A5029218574- Genetic Associations and Epidemiology
- Sleep and related disorders
- Sleep and Wakefulness Research
- Bioinformatics and Genomic Networks
- Obstructive Sleep Apnea Research
- Metabolomics and Mass Spectrometry Studies
- Genetics and Neurodevelopmental Disorders
- Circadian rhythm and melatonin
- Genetics, Bioinformatics, and Biomedical Research
- Tryptophan and brain disorders
- Sleep and Work-Related Fatigue
- Autism Spectrum Disorder Research
- Cardiovascular Disease and Adiposity
- Cognitive Abilities and Testing
- Mental Health Research Topics
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Attention Deficit Hyperactivity Disorder
- Health and Well-being Studies
- Organ Transplantation Techniques and Outcomes
- Inflammatory Bowel Disease
- Glioma Diagnosis and Treatment
- Healthcare professionals’ stress and burnout
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Clinical Reasoning and Diagnostic Skills
First Affiliated Hospital of Xi'an Jiaotong University
2010-2025
Zhongnan Hospital of Wuhan University
2016-2024
Wuhan University
2016-2024
Xi'an Jiaotong University
2018-2024
First Affiliated Hospital Zhejiang University
2023
Southwest Medical University
2020-2022
XinHua Hospital
2021-2022
Shanghai Jiao Tong University
2021-2022
Huazhong Agricultural University
2022
ORCID
2020
Abstract Psychiatric disorders are the leading cause of disability worldwide while pathogenesis remains unclear. Genome-wide association studies (GWASs) have made great achievements in detecting disease-related genetic variants. However, functional information on underlying biological processes is often lacking. Current reports propose use metabolic traits as intermediate phenotypes (the so-called genetically determined metabotypes or GDMs) to reveal mechanisms genetics human diseases. Here...
Childhood neurodevelopmental disorders, including autism spectrum disorder (ASD), attention-deficit hyperactivity (ADHD), and Tourette syndrome (TS), comprise a major cause of health-related disabilities in children. However, biomarkers towards pathogenesis or novel drug targets are still limited. Our study aims to provide comprehensive investigation the causal effects plasma proteome on ASD, ADHD, TS using two-sample Mendelian Randomization (MR) approach.Genetic associations with 2994...
Abstract Background Virtual simulation and face-to-face are effective for clinical judgment training. Rare studies have tried to improve ability by applying virtual together. This study aimed evaluate the effect of an integrated non-immersive high-fidelity program on enhancing nursing students’ understanding experiences combined simulation. Methods A sequential exploratory mixed-methods was conducted in a center university Central China. Third-year students ( n = 122) taking training ICUs...
Background There was little evidence about the role of objective sleep efficiency (SE) in incidence major cardiovascular disease (CVD) events. The purpose this study to investigate correlation between SE and CVD based on polysomnography. Methods Results A total 3810 participants from SHHS (Sleep Heart Health Study) were selected current study. assessed during an almost 11‐year follow‐up period. primary composite outcome adverse events, defined as mortality, congestive heart failure,...
Schizophrenia (SCZ) is associated with several immune dysfunctions, including elevated levels of pro-inflammatory cytokines. Microorganisms and their metabolites have been found to regulate the system, that intestinal microbiota significantly disturbed in schizophrenic patients. To systematically investigate aberrant gut-metabolome-immune network schizophrenia, we performed an integrative analysis microbiota, serum metabolome, inflammatory cytokines 63 SCZ patients 57 healthy controls using...
Background Previous studies found an association between self‐reported sleep duration and mortality. This study aimed to compare the effects of objective on all‐cause cardiovascular disease (CVD) Methods Results A total 2341 men 2686 women (aged 63.9±11.1 years) were selected from SHHS (Sleep Heart Health Study). Objective was acquired using in‐home polysomnography records, weekdays weekends based a habits questionnaire. The categorized as ≤4 hours, 4 5 6 7 8 >8 hours. Multivariable Cox...
It has been reported that schizophrenia (SCZ) and inflammatory bowel disease (IBD) are related. However, whether there is a bidirectional interaction between them remains unclear. The aim of this study was to conduct Mendelian randomization (MR) analysis elucidate the causal relationship SCZ IBD its subtypes, including Crohn's (CD) ulcerative colitis (UC). Single-nucleotide polymorphisms (SNPs) extracted from summary data genome-wide association studies were used as genetic instruments. MR...
Sex hormones are involved in schizophrenia pathogenesis; however, their direction and genetic overlap remain unknown. By leveraging summary statistics from large-scale genome-wide association studies, we quantified the shared architecture between four sex hormone traits. Linkage disequilibrium score regression bivariate causal mixture modeling strategies showed significant positive correlations hormone-binding globulin (SHBG), total testosterone, schizophrenia, while bioavailable...
Following a ban on antibiotic use in the feed industry, trials effects of various immunostimulants (prebiotics, probiotics, antimicrobial peptides [AMPs], and herbs) survival, growth, immunity, disease control farmed fish aquaculture are being rapidly conducted. The wide variety microbes with roles nutrition, metabolism, immunity intestine is primary factor affecting fermentability functionality dietary immunostimulants. For this reason, dynamic interactions between intestinal microbiome may...
5-Hydroxytryptophan (5-HTP) has positive clinical effects on various neuropsychiatric and metabiotic disorders, especially depression. Although it increases serotonin levels in the brain gastrointestinal tract, its pharmacology remains largely unknown. Our goal was to determine of 5-HTP mouse gut microbiome, which a close relationship with depression through "microbiota-gut-brain axis." We confirmed that depressive disorder restructures microbial community, efficiently improves symptoms...
Abstract Aims This study explores how perceived organizational support for strengths use influences nurses’ job performance, specifically examining the mediating effects of control beliefs about stress and optimism. Background Identifying factors that enhance performance is crucial in demanding field nursing. Previous research has highlighted positive impact on performance. Method Conducted between May October 2023, this involved 653 nurses from various hospital settings across three Chinese...
Macrocytic anemia is common in liver disease. However, its role hepatitis B virus (HBV)-related decompensated cirrhosis remains unknown. The aim of the present study was to determine association between macrocytic and severity impairment patients with HBV-related according Model for End Stage Liver Disease (MELD) score.A total 463 participants who fulfilled our criteria were enrolled this cross-sectional study. Patients classified into three groups types, diagnosed based on their mean...
The aim of this study was to investigate the association bedtime with prevalence diabetes mellitus (DM) based on a large community-based population.
Abstract Objective Sleep disturbances have been recognized as a risk factor for obesity. This study used polysomnography records to investigate associations between sleep fragmentation and Methods Objectively measured data recorded by in‐home polysomnography, including total arousal index (ArI‐total), ArI in rapid eye movement (REM) (ArI‐REM), non‐REM (ArI‐NREM), index, efficiency (SE), wake after onset (WASO), were based on the Heart Health Study (2,835 men 2,888 women with mean [SD] age of...
Objective: Sleep has a significant influence on the incidence of myocardial infarction (MI). The purpose this study was to investigate association between sleep timing including bedtime, wake-up time and midpoint, MI. Methods: A total 4,576 patients (2,065 men, 2,511 women; age 63.4 ± 11.0 years) were selected from Heart Health Study. timings weekdays weekends recorded or calculated based habits questionnaire completed by participants at baseline. Bedtime divided into 10:00 PM before, 10:01...
Antithyroid drug (ATD)-induced agranulocytosis is associated with human leukocyte antigen (HLA) and nearby genes in Southeast Asian European populations. The susceptibility of the Han population from northern China to ATD-induced has not been reported. We evaluated associations genetic variants at HLA-B HLA-DRB1 loci 32 candidate single nucleotide polymorphisms (SNPs) 29 patients 140 Graves' disease (GD) as controls. All subjects were descent China. HLA-B*27:05 (P = 1.10 × 10-4), HLA-B*38:02...
Sleeping habits have been reported to be associated with diabetes mellitus. This study aimed explore the relationship of sleep efficiency mellitus in individuals or without sleep-disordered breathing based on polysomnography records.We enrolled participants from Sleep Heart Health Study. Objective indicators characteristics including efficiency, latency, slow-wave sleep, wake after onset, and total arousal index were monitored via in-home polysomnography. was divided into grade 1 (≥85%), 2...
Objectives: The purpose of our study was to investigate the effect objective sleep characteristics on incidence depression. Methods participants (1,595 men and 1,780 women with 63.1 ± 10.7 years) were selected from Sleep Heart Health Study (SHHS) datasets. Depression defined as first occurrence between SHHS visit 1 2. Objective characteristics, including efficiency (SE), wake after onset (WASO), fragmentation index (SFI) arousal (ArI), monitored by polysomnography. Multivariable logistic...