A5061224769- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Developmental Biology and Gene Regulation
- Wastewater Treatment and Reuse
- Insect Utilization and Effects
- Insect and Arachnid Ecology and Behavior
- Constructed Wetlands for Wastewater Treatment
- Hydrogen Storage and Materials
- Cancer Cells and Metastasis
- Autophagy in Disease and Therapy
- Environmental Impact and Sustainability
- Phosphorus and nutrient management
- Cholesterol and Lipid Metabolism
- Fuel Cells and Related Materials
- Advancements in Solid Oxide Fuel Cells
- Circadian rhythm and melatonin
- Preterm Birth and Chorioamnionitis
- Estrogen and related hormone effects
- TGF-β signaling in diseases
- Aquatic Ecosystems and Biodiversity
- FOXO transcription factor regulation
- Surgical Simulation and Training
- Kruppel-like factors research
- Intraocular Surgery and Lenses
- Silk-based biomaterials and applications
Huazhong University of Science and Technology
2020-2024
Chongqing Medical University
2020-2024
Army Medical University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Shanghai Institute of Computing Technology
2024
Nanjing Institute of Geography and Limnology
2020-2023
Chinese Academy of Sciences
2007-2023
Nanjing University of Information Science and Technology
2023
University of Chinese Academy of Sciences
2007-2022
Second Hospital of Shanxi Medical University
2022
Drosophila intestinal stem cells (ISCs) generate enterocytes (ECs) and enteroendocrine (ee) cells. Previous work suggests that different levels of the Notch ligand Delta (Dl) in ISCs unidirectionally activate daughters to control multipotency. However, mechanisms driving outcomes remain unknown. We found during ee cell formation, marker Prospero localizes basal side dividing ISCs. After asymmetric division, daughter acts as a source Dl induces low activity ISC maintain identity....
Although much is known about injury-induced signals that increase rates of Drosophila melanogaster midgut intestinal stem cell (ISC) proliferation, it largely unknown how ISC activity returns to quiescence after injury. In this paper, we show the bone morphogenetic protein (BMP) signaling pathway has dual functions during homeostasis. Constitutive BMP activation in middle mediated regional specification by promoting copper differentiation. anterior and posterior midgut, acted autonomously...
The Drosophila ovary is an excellent system with which to study germline stem cell (GSC) biology. Two or three female GSCs are maintained in a structure called niche at the anterior tip of ovary. somatic cells surrounding include terminal filament cells, cap and escort cells. Mounting evidence has demonstrated that BMP-like morphogens immediate upstream signals promote GSC fate by preventing expression Bam, key differentiation factor. In contrast their morphogenic long-range action imaginal...
Abstract Amino acid availability is monitored by animals to adapt their nutritional environment. Beyond gustatory receptors and systemic amino sensors, enteroendocrine cells (EECs) are believed directly percept dietary acids secrete regulatory peptides. However, the cellular machinery underlying acid-sensing EECs how EEC-derived hormones modulate feeding behavior remain elusive. Here, developing tools specifically manipulate EECs, we find that Drosophila neuropeptide F (NPF) from mated...
Epithelial-repair-dependent mucosal healing (MH) is associated with a more favorable prognosis for patients inflammatory bowel disease (IBD). MH accomplished via repair and regeneration of the intestinal epithelium. However, mechanism underlying ill defined. We found striking upregulation peroxisomes in injured crypts IBD patients. By increasing peroxisome levels Drosophila midguts, we that elevation enhanced RAB7-dependent late endosome maturation, which then promoted stem and/or...
Hepatocellular carcinoma (HCC) is one of the most malignant tumors and fourth leading cause cancer-related death worldwide. Sorafenib currently acknowledged as a standard therapy for advanced HCC. However, acquired resistance substantially limits clinical efficacy sorafenib. Therefore, further investigations associated risk factors are highly warranted.We analysed group 78 HCC patients who received sorafenib treatment after liver resection surgery. The expression SCAP its correlation with in...
Apical-basal polarity and cell-fate determinants are crucial for the cell fate control of stem numbers. However, their interplay leading to a precise number remains unclear. Drosophila pupal intestinal cells (pISCs) asymmetrically divide, generating one apical ISC progenitor basal Prospero (Pros)+ enteroendocrine mother (EMC), followed by symmetric divisions each daughter before adulthood, providing an ideal system investigate outcomes loss. Using lineage tracing ex vivo live imaging, we...
Atherosclerosis is a serious age-related pathology, and one of its hallmarks the presence chronic inflammation. Sterol regulatory element-binding protein (SREBP) cleavage-activating (SCAP) cholesterol sensor that plays an essential role in regulating intracellular homeostasis. Accordingly, dysregulation SCAP-SREBP pathway has been reported to be closely associated with increased risk obesity, hypercholesterolemia, cardiovascular disease. In this study, we explored whether sterol-resistant...
As a type of time series data, trajectory data objectively record the location information and corresponding an object’s activities. It not only describes spatial activity moving object but also contains unique attributes, states, behavioral characteristics itself. can reflect interaction relationship between activities various elements in environment to certain extent. Therefore, mining from target discover implicit, effective, potentially useful spatiotemporal behavior patterns targets,...
As the major source of air pollution, sulfur dioxide (SO2) emissions have become focus global attention. However, existing studies rarely consider spatial effects when discussing relationship between foreign direct investment (FDI) and SO2 emissions. This study took Yangtze River Delta as research area used panel data 26 cities in this region for 2004–2017. The investigated agglomeration dynamics at work FDI by using local measures autocorrelation. Then, based on regression analysis a...
Abstract Background During the coronavirus disease 2019 (COVID-19) epidemic, due to traffic blockade and shortage of medical resources, more premature infants could not receive timely effective ROP screening, which delayed treatment even caused children blindness. Therefore, how carry out screening safely effectively during epidemic was very important urgent. This study aimed evaluate safety feasibility assisted by telemedicine network COVID-19 outbreak. Methods retrospective conducted at...
Objective . In a group case series, the clinical characteristics of congenital membranous cataract in children were studied to establish system classification and determine surgical method suited for each type. Methods Children (18 eyes) with examined by slit lamp, ultrasound biomicroscopy, operating microscopy classify cataracts. The its feature related analyzed. Results Five major types cataracts classified. All surgeries successful. Anterior posterior capsulorhexis was performed using...
Abstract Aging or injury in Drosophila intestine promotes intestinal stem cell (ISC) proliferation and enteroblast (EB) differentiation. However, the manner local physiology couples with dynamic EB differentiation assessed by traditional lineage tracing method is still vague. Therefore, we developed a 3D-printed platform “FlyVAB” for intravital imaging strategy that enables visualization of posterior midgut at single level across ventral abdomen cuticle. Using ISCs young healthy...
Direct ammonia SOFC (DA-SOFC), being free from the storage and transportation issues encountered by using pure hydrogen, is a promising automotive power auxiliary technology. In this study, single-channel model of planar DA-SOFC was established numerical simulations were performed to investigate effects bipolar plate flow channel configurations (namely triangle, quadrangle, oval geometry, along with various size parameters) on thermal-electric performance DA-SOFC. Results show that...