A5100418773- Gut microbiota and health
- Diet and metabolism studies
- Tryptophan and brain disorders
- Helicobacter pylori-related gastroenterology studies
- Advanced biosensing and bioanalysis techniques
- Prion Diseases and Protein Misfolding
- Traumatic Brain Injury and Neurovascular Disturbances
- Pharmacological Effects of Natural Compounds
- DNA and Biological Computing
- Systemic Lupus Erythematosus Research
- Ferroptosis and cancer prognosis
- Ginseng Biological Effects and Applications
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Clostridium difficile and Clostridium perfringens research
- Advanced Memory and Neural Computing
- S100 Proteins and Annexins
- Neonatal and fetal brain pathology
- Mycobacterium research and diagnosis
- Neurological diseases and metabolism
- Probiotics and Fermented Foods
- Inflammatory Bowel Disease
- Retinal Diseases and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammatory Myopathies and Dermatomyositis
Capital Medical University
2022-2025
National Health and Family Planning Commission
2024
Xi'an Jiaotong University
2022-2024
Affiliated Hospital of Shaanxi University of Chinese Medicine
2024
Chengdu Third People's Hospital
2024
Weatherford College
2024
University of South China
2024
Hunan Children's Hospital
2024
Baotou Teachers College
2022-2024
Wuhan University
2023
High-fat diet, which leads to an increased level of deoxycholic acid (DCA) in the intestine, is a major environmental factor development colorectal cancer (CRC). However, evidence relating bile acids and intestinal tumorigenesis remains unclear. In this study, we investigated effects DCA on mucosal barrier its impact CRC. Here showed that disrupted cell monolayer integrity proinflammatory cytokine production precancerous lines (Caco-2 IMCE). Apcmin/+ mice receiving number size adenomas...
Abstract The gut microbiota and the bile acid pool play pivotal roles in maintaining intestinal homeostasis. Bile acids are produced liver from cholesterol metabolized intestine by microbiota. Gut dysbiosis has been reported to be associated with colorectal cancer. However, interplay between metabolism during carcinogenesis remains unclear. In present study, we investigated potential of cholic (CA; a primary acid)‐induced adenoma‐adenocarcinoma sequence. Apc min/+ mice, which spontaneously...
Abstract Objective Gut mycobiota plays a crucial role in benign liver diseases; however, its correlation with hepatocellular carcinoma (HCC) remains elusive. This study aimed to elucidate fungal differences patients HCC-associated cirrhosis compared cirrhotic without HCC and healthy controls. Methods The 72 fecal samples from 34 patients, 20 18 controls were collected analyzed using ITS2 rDNA sequencing. Results Our results revealed the presence of intestinal dysbiosis significant enrichment...
Abstract High‐fat diet (HFD) is a well‐known risk factor for gut microbiota dysbiosis and colorectal cancer (CRC). However, evidence relating HFD, carcinogenesis limited. Our study aimed to demonstrate that HFD‐induced promoted intestinal adenoma‐adenocarcinoma sequence. In clinical study, we found HFD increased the incidence of advanced neoplasia (AN). The expression monocyte chemoattractant protein 1 (MCP‐1), CC chemokine receptor 2 (CCR2) CD163 in CRC patients with was significantly...
The gut microbiome plays an indispensable role in the occurrence and progression of various diseases. However, its ability to predict gastric cancer (GC) liver metastasis (GCLM) has not been fully identified.
Traumatic brain injury often causes poor outcomes and has few established treatments. Neuroinflammation ferroptosis hinder therapeutic progress in this domain. Annexin A5 (A5) anticoagulant, anti-apoptotic anti-inflammatory bioactivities. However, its protective effects on traumatic remain unclear. Thus, we explored whether inhibiting neuroinflammation using could ameliorate injury. We injected recombinant (50 µg/kg) the tail vein of mice 30 min after fluid percussion then assessed modified...
Alzheimer's disease (AD) is a prevalent neurodegenerative (ND). In recent years, multiple clinical and animal studies have shown that mitochondrial dysfunction may be involved in the pathogenesis of AD. addition, short-chain fatty acids (SCFA) produced by intestinal microbiota metabolism been considered to important factors affecting central nervous system (CNS) homeostasis. Among main mediators host-microbe interactions, volatile play crucial role. Nevertheless, influence pathways...
The roles of immunodeficiency and combined antiretroviral therapy (cART) in shaping the gut microbiota HIV-1-infected subjects (HISs) have not been described thoroughly by time-series investigations. In this study, 36 antiretroviral-naïve HISs were enrolled to prospectively assess alterations fecal plasma markers microbial translocation inflammation with cART. At baseline, species α-diversity was significantly lower a CD4+ T cell count <300/mm3 than >300/mm3 (Shannon index: Median 2.557 vs....
Inflammatory bowel disease (IBD), characterized by sustained inflammation, is a latent risk factor of colon tumorigenesis. Silibinin has been reported to be anti-inflammatory and antineoplastic, but its efficacy on colitis-associated cancer (CAC) not reported. Interlukin-6/signal transducer activator transcription 3 (IL-6/STAT3) the key signaling pathway involved in CAC. We evaluated chemopreventive effect silibinin CAC mouse model determined impact IL-6/STAT3 signaling. Intestinal tumor...
Coagulopathy often develops soon after acute traumatic brain injury and its cause remains poorly understood. We have shown that injured brains release cellular microvesicles disrupt the endothelial barrier induce consumptive coagulopathy. Morphologically intact extracellular mitochondria accounted for 55.2% of these microvesicles, leading to hypothesis are metabolically active serve as a source oxidative stress activates platelets renders them procoagulant. In testing this experimentally, we...
Background Growing evidence supports that alterations in the gut microbiota play an essential role etiology of anxiety, depression, and other psychiatric disorders. However, potential effect oral on mental health has received little attention. Methods Using latest genome-wide association study (GWAS) summary data microbiome, polygenic risk scores (PRSs) 285 salivary microbiomes 309 tongue dorsum were conducted. Logistic linear regression models applied to evaluate relationship between...
Patients with prolonged inflammatory bowel disease (IBD) can develop into colorectal cancer (CRC), also called colitis-associated (CAC). Studies have shown the association between gut dysbiosis, abnormal bile acid metabolism, and inflammation process. Here, we aimed to investigate these two factors in CAC model. C57BL/6 mice were randomly allocated groups: azoxymethane/dextran sodium sulfate (AOM/DSS) control. The AOM/DSS group received AOM injection followed by DSS drinking water....
5-Hydroxytryptophan (5-HTP) has positive clinical effects on various neuropsychiatric and metabiotic disorders, especially depression. Although it increases serotonin levels in the brain gastrointestinal tract, its pharmacology remains largely unknown. Our goal was to determine of 5-HTP mouse gut microbiome, which a close relationship with depression through "microbiota-gut-brain axis." We confirmed that depressive disorder restructures microbial community, efficiently improves symptoms...
Introduction Gut microbiota are closely related to the nutrition, immunity, and metabolism of host play important roles in maintaining normal physiological activities animals. Cranes protected avian species China, they sensitive changes ecological environment thus good environmental indicators. There have been no reports examining gut fungi or correlation between bacteria wild Demoiselle cranes ( Grus virgo ) Common grus ). Related research can provide a foundation for protection rare...
The gut microbiota contributes to host health by improving digestive efficiency and maintaining homeostasis. relict gull (Larus relictus), a national first-class protected bird in China, is listed as vulnerable the International Union for Conservation of Nature Red List. Here, 16S rRNA gene sequencing was performed characterize compare community composition diversity sampled from gulls two breeding sites. In total, 418 operational taxonomic units (OUTs) were obtained classified into 15 phyla...
Abstract High fat diet is implicated in the elevated deoxycholic acid ( DCA ) intestine and correlated with increased colon cancer risk. However, potential mechanisms of intestinal carcinogenesis by remain unclarified. Here, we investigated carcinogenic effects using tumour cells Apc min/+ mice model. We found that could activate epidermal growth factor receptor EGFR promote release ligand amphiregulin AREG ), but not HB ‐ EGF or TGF ‐α cells. Moreover, ADAM ‐17 was required ‐induced...
The aim was to investigate the relationship between retinol-binding protein 4 (RBP4) levels and short-term functional outcome, determine its possible role in acute ischemic stroke (AIS). In a prospective observational study, 299 first-ever AIS who were admitted our hospital included. Serum of RBP4 assayed severity evaluated with National Institutes Health Stroke Scale (NIHSS) score on admission. prognostic value predict poor outcome within 3 months compared NIHSS other known predictors....
Circulating platelets are anucleated and multi-functional cells that participate in hemostasis arterial thrombosis. Multiple ligands mechanical forces activate platelets, leading to cytoskeletal rearrangement dramatic shape-changes. Such changes membrane structures commonly detected by optical electron microscopy after fixed. We have recently developed a method study the morphology of live using Hopping Probe Ion Conductance Microscopy (HPICM). successfully used this technology process...