A5102945587- Gastric Cancer Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Lipids, and Metabolism
- S100 Proteins and Annexins
- Smart Grid and Power Systems
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Heme Oxygenase-1 and Carbon Monoxide
- Metabolism, Diabetes, and Cancer
- Power Systems and Technologies
- Pancreatitis Pathology and Treatment
- Chemokine receptors and signaling
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- High-Voltage Power Transmission Systems
- Pancreatic and Hepatic Oncology Research
- Advanced Computational Techniques and Applications
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Surgical Treatments
- Advanced Glycation End Products research
- Circular RNAs in diseases
- Protease and Inhibitor Mechanisms
- Gastroesophageal reflux and treatments
- Distributed and Parallel Computing Systems
- Cancer Immunotherapy and Biomarkers
Tianjin Medical University General Hospital
2022-2025
Peking University
2019-2025
Peking University Third Hospital
2019-2025
Fujian Provincial Cancer Hospital
2016-2024
Fujian Medical University
2016-2023
State Grid Corporation of China (China)
2017-2023
Hubei University of Technology
2023
First Hospital of Qinhuangdao
2022-2023
Ministry of Education of the People's Republic of China
2022-2023
Tianjin Medical University
2022-2023
Traumatic brain injury often causes poor outcomes and has few established treatments. Neuroinflammation ferroptosis hinder therapeutic progress in this domain. Annexin A5 (A5) anticoagulant, anti-apoptotic anti-inflammatory bioactivities. However, its protective effects on traumatic remain unclear. Thus, we explored whether inhibiting neuroinflammation using could ameliorate injury. We injected recombinant (50 µg/kg) the tail vein of mice 30 min after fluid percussion then assessed modified...
Metabolic syndrome (MetS) has been shown to be associated with an increased risk of gastric cancer. However, the impact MetS on cancer mortality remains largely unknown. Here, we prospectively examined prediction preoperative for by analyzing a subset data from ongoing Fujian prospective investigation (FIESTA) study. This study was conducted among 3012 patients who received radical gastrectomy between 2000 and 2010. The latest follow-up completed in 2015. Blood/tissue specimens, demographic...
Gastrointestinal amyloidosis (GIA) is a rare manifestation of amyloidosis, characterized by amyloid fibril deposition in the gastrointestinal tract, leading to range clinical symptoms. Early diagnosis challenging due nonspecific nature endoscopic and findings. To analyze clinical, endoscopic, pathological characteristics GIA identify potential diagnostic markers for earlier detection. A retrospective study was conducted on 36 patients diagnosed with based histopathological findings,...
Background and Purpose: Neuroinflammation has been shown to play a critical role in secondary craniocerebral injury, leading poor outcomes for TBI patients. Abrocitinib, Janus kinase1 (JAK1) selective inhibitor approved treat atopic dermatitis (AD) by the Food Drug Administration (FDA), possesses novel anti-inflammatory effect. In this study, we investigated whether abrocitinib could ameliorate neuroinflammation exert neuroprotective effect traumatic brain injury (TBI) models. Methods:...
CMTM4 (CKLF-like MARVEL transmembrane domain containing 4), a potential tumor suppressor gene, is involved in several types of malignancies. It has been reported to be downregulated and exhibit anti-tumorigenic activities by regulating cell growth cycle clear renal carcinoma. also identified as hepatocellular carcinoma (HCC), its negative expression risk factor for poor prognosis HCC patients. In the present study, an integrated bioinformatics analysis based on The Cancer Genome Atlas (TCGA)...
Traumatic brain injury (TBI) can negatively impact systemic organs, which lead to more death and disability. However, the mechanism underlying effect of TBI on organs remains unclear. In previous work, we found that brain-derived extracellular vesicles (BDEVs) released from injured induce coagulation with a widespread fibrin deposition in microvasculature lungs, kidney, heart mouse model TBI. this study, investigated whether BDEVs heart, lung, liver, kidney mice. The results pathological...
Objectives: We sought to determine the optimal cutting points for two inflammatory biomarkers, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte (PLR), assess their prognostic value in patients with postoperative digestive tract cancers overall by cancer sites, further construct an inflammation-related index based on biomarkers its predictive performance. Methods: Total 6,865 assessable who underwent tumor resection were consecutively enrolled from Fujian Cancer Hospital...
Brain induced extracellular vesicle (BDEV) elevates after traumatic brain injury (TBI) and contributes to secondary injury. However, the role of BDEV in TBI remains unclear. In this study, we determined mechanisms explored whether neuroprotective drug BKca channel opener NS1619 may attenuate BDEV-induced We injected lactadherin, respectively, mimic up downregulation illustrated vivo. vitro, membrane potential calcium concentration HT-22, bEnd3, BV-2 were measured by fluorescent staining. The...
Aims: Annexin A5 (ANXA5) exhibited potent antithrombotic, antiapoptotic, and anti-inflammatory properties in a previous study. The role of ANXA5 traumatic brain injury (TBI)-induced intestinal is not fully known. Main methods: Recombinant human (50 µg/kg) or vehicle (PBS) was administered to mice via the tail vein 30 min after TBI. Mouse intestine tissue gathered for hematoxylin eosin staining 0.5 d, 1 2 7 d modeling. Intestinal Western blotting, immunofluorescence, TdT-mediated dUTP...
Previous studies have proved that cardiac dysfunction and myocardial damage can be found in TBI patients, but the underlying mechanisms of induced by can't illustrated. We want to investigate function ferroptosis after determine if inhibiting iron overload might lessen injury due involvement process inflammation. detect expression ferroptosis-related proteins tissue at different time points TBI, indicating cause heart vivo. The echocardiography enzymes results showed aggravate TBI-induced...
This paper introduces the structure of existing on-line monitoring system, and analyzes problems poor compatibility reliability IED in different manufacturers. Then it gives two ways to transform system substation equipment Internet things, which is retain remove IED. On this basis, application scenarios connected including accurate perception status, evaluation status intelligent research judgment status.
A direct-type lead exit for ultra high voltage (UHV) transformer was designed, and the electric field of calculated analyzed by using finite element method. Then, its insulation structure optimized. The stress distribution displacement under vibration condition were investigated. reliability verified electrical test test.
Intestinal injury caused by traumatic brain (TBI) seriously affects patient prognosis; however, the underlying mechanisms are unknown. Recent studies have demonstrated that ferritinophagy-mediated ferroptosis is involved in several intestinal disorders. However, uncertainty persists regarding role of damage TBI. High-throughput transcriptional sequencing was used to identify genes were differentially expressed intestine after The tissues harvested for hematoxylin and eosin staining (HE),...
Backgrounds: High blood glucose or hyperglycemia is an established risk factor for the development and progression of cancer at many sites, whereas data on relevance between low hypoglycemia survival are lacking. Aims: We aimed to assess shape trajectory preoperative fasting postoperative digestive cancer-specific mortality in Chinese. Methods: In total, 6865 patients who underwent radical surgery esophageal (n=2535), gastric (n=3012) colorectal (n=1318) during 2000-2010 were followed up as...
<title>Abstract</title> PD-L1 inhibitors are more effective for patients with CPS ≥ 5 or EBV positivity in gastric cancer. However, determining and expression requires costly complex immunohistochemistry staining situ hybridization techniques. Therefore, there is a strong need to develop an AI system assess expressions using H&E-stained slides. We developed based on slides, including 432 cases collected from Fujian Cancer Hospital, 258 the TCGA-STAD dataset. The backbone network was...
CKLF-like MARVEL transmembrane domain-containing 4 (CMTM4) is involved in immune regulation and tumor progression; however, its role gastric cancer (GC) remains unclear. This study explored the mechanism of CMTM4 GC.
Background: We aimed to investigate the interaction between prediabetes and ABO blood types in predicting esophageal squamous cell carcinoma (ESCC)-specific mortality by analyzing data from FIESTA study on normal/prediabetic patients with ESCC. Methods: Total 1857 ESCC who underwent three-field lymphadenectomy January 2000 December 2010 survived hospitalization were analyzable, follow-up beginning ending 2015. Results: At end of follow-up, there 1161 survivors 696 non-survivors. The time...
Objective To reduce the occurrence of recurrent choledocholithiasis caused by biliary sphincter dysfunction after extensive endoscopic sphincterotomy (EST) for large stone extraction, and to investigate sphincter-preserving effects duodenal papilla occlusion SureClip from MicroTech. Methods Three patients with stones (1.0-2.5 cm in size, 1.2-3.0 common bile duct diameter) without ERCP history underwent EST (larger than 1.0 cm) Peking University Third Hospital March 2018 May 2018....
Abstract Background Brain induced extracellular vesicle (BDEV) are increased after traumatic brain injury (TBI) but their role in secondary is unclear. The question whether and how BDEV involved neuroprotective drugs BKCa channel openers NS1619 may attenuate BDEV-induced makes sense. Methods First, was extracted from enzymatically digested brains TBI. Second, we injected lactadherin to mimic the up- down-regulation of respectively TBI determined vivo. In vitro, membrane potential calcium...
Background and Objectives: Emerging evidence indicates that hypertension is a potential risk prognostic factor for cancer at many sites.Currently, no data are available on optimal blood pressure target in patients with resectable digestive tract cancer.Here, we did an exploratory analysis 6865 from the FIESTA cohort to identify baseline can better predict cancer-specific mortality postoperatively.Methods Results: Patients were enrolled between January 2000 December 2010, follow-up ending...
The rapid development of China’s construction industrialization process has led to increased research into prefabricated building structures. In comparison cast-in-place construction, buildings offer many advantages. Increasingly important been on joints’ seismic performance. A beam, slab, column, and wall’s connection affects its performance, each joint different characteristics. light this, this paper analyzed the performance joints based their application.