A5004998822- Cancer Cells and Metastasis
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- IL-33, ST2, and ILC Pathways
- Helicobacter pylori-related gastroenterology studies
- Ubiquitin and proteasome pathways
- Glioma Diagnosis and Treatment
- Gut microbiota and health
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Immune cells in cancer
- Sarcoma Diagnosis and Treatment
- Extracellular vesicles in disease
- Galectins and Cancer Biology
- Cytokine Signaling Pathways and Interactions
- Inflammatory Bowel Disease
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Management of metastatic bone disease
- Genomic variations and chromosomal abnormalities
- Diabetes Treatment and Management
Peking University
2020-2024
Peking University Third Hospital
2020-2024
Beijing Normal University
2017-2019
Chinese Institute for Brain Research
2017-2018
EZH2 inhibitors (EZH2i), a class of small-molecule that target to exert anti-tumor functions, have just been approved by the US Food and Drug Administration (FDA) in treatment adults adolescents with locally advanced or metastatic epithelioid sarcoma. The application EZH2i several solid tumors is still different stages clinical trials needs be further validated. As key epigenetic regulator, besides its role controlling proliferation tumor cells, has implicated regulation various immune cells...
Sensitivity has been a key issue for Enhancer of zeste homolog 2 (EZH2) inhibitors in cancer therapy. The EZH2 inhibitor EPZ-6438 was first approved by the US Food and Drug Administration (FDA) 2020. However, its inadequate anti-cancer activity solid tumors limits clinical application. In this study, we utilized multiple cell lines, which are less sensitive to GSK126, combining animal model data investigate underlying mechanism.IncuCyte S3 used explore difference responsiveness hematological...
Gastric cancer treatment is complicated by the molecular heterogeneity of human tumor cells, which limits efficacy standard therapy and necessitates need for personalized development. Patient-derived organoids (PDOs) are promising preclinical models, exhibiting high clinical in predicting drug sensitivity, thus providing a new means precision medicine.PDOs were established from surgically resected gastric tissues. Molecular characterization tissues PDOs was performed using whole-exome...
Lung adenocarcinoma (LA) is the most commonly occurring histological type of non‑small cell lung cancer. Diagnosis and treatment LA remain a major clinical challenge. In present study, to identify early biomarkers, extracellular vesicles (EVs) were separated from plasma samples 153 patients with 75 healthy controls. microRNA (miRNA) expression profiling was performed at screening stage (5 vs. 5 controls), followed by verification validation (40 20 controls) using reverse...
Abstract Luteolin (Lut) has been shown to inhibit gastric cancer (GC); however, its efficacy compared other clinical drugs not examined in human samples. This study aimed elucidate the antitumor activity of Lut GC patient‐derived organoids (PDOs). PDOs were established from tissues, and characterization tissues was performed using whole‐exome sequencing. Drug sensitivity tests by treating with Lut, norcantharidin (NCTD), carboplatin (CP). RNA sequencing mechanism which further verified three...
The dysfunction of innate immunity components is one the major drivers for ulcerative colitis (UC), and increasing reports indicate that gut microbiome serves as an intermediate between genetic mutations UC development. Here, we find IL-17 receptor subunit, CMTM4, reduced in patients DSS-induced colitis. deletion CMTM4 (Cmtm4-/-) mice leads to a higher susceptibility comparison wildtype, significantly changes composition. causal role confirmed with co-housing experiment. We further identify...
The noninvasive detection technique using serum for large-scale screening is useful the early diagnosis of gastric cancer (GC). Herein, we employed liquid chromatography mass spectrometry to determine proteome signatures and related pathways in individuals with precancerous (pre-GC) lesions GC explore effect Helicobacter pylori ( H. ) infection. Differentially expressed proteins pre-GC compared non-atrophic gastritis (NAG) group were identified. APOA4, a protein associated metaplastic...
Abstract Background To compare the effectiveness of intraoperative cell salvage (IOCS) combined with a modified leucocyte depletion filter (MLDF) IOCS regular (RLDF) in eliminating tumour cells from blood during metastatic spine surgery (MSTS). Methods Patients known primary epithelial who underwent MSTS were recruited for this study. Blood samples collected 5 stages: patients’ vein before anaesthesia induction (S1), operative field at time maximum manipulation (S2), and after processing...
Abstract Background Intra-operative cell salvage (IOCS) and leukocyte-depleted filter (LDF) are widely used effective in saving blood. However, the safety issue concerning reinfusion of IOCS–LDF processed blood to renal carcinoma (RCC) patients with inferior vena cava (IVC) thrombus were inconclusive for fear increased risk cancer metastases. This study intends analyze circulating tumor (CTC) eliminating effect 5 RCC–IVC patients. Methods A novel strategy integrating negative enrichment by...
Tetratricopeptide repeat (TPR) domain 3 (TTC3) is a protein that contains canonical RING finger and TPR motifs. It encoded by the TTC3 gene located in Down syndrome critical region (DSCR). In this study, we used yeast two-hybrid assay to identify several proteins physically interact with TTC3, including heat shock DNA polymerase γ (POLG). When was overexpressed mammalian cells, ubiquitination of POLG inhibited its degradation slowed. High expression led development intracellular aggregates,...
CKLF-like MARVEL transmembrane domain-containing 4 (CMTM4) is involved in immune regulation and tumor progression; however, its role gastric cancer (GC) remains unclear. This study explored the mechanism of CMTM4 GC.
e15523 Background: Detection and excision of early-stage CRC or colorectal precancerous lesions (advanced adenoma) has been recognized as an effective way to reduce induced mortality. Integrating signals from both tumoral tissues microenvironment exhibit better accuracy for tumor detection, especially tumors. Gut microbiome carried out profound effects on initiation progression cancer adenoma, our previous findings have also revealed that gut microbiome-associated serum metabolites exhibited...
Introduction Refractory peptic ulcers lead to perforation and hemorrhage, which are fatal. However, these remain a therapeutic challenge. Gastric mucosal blood flow is crucial in maintaining gastric health. It’s reported that Glucagon-like peptide-2 (GLP-2), gastrointestinal hormone, stimulated intestinal flow. the direct role of GLP-2 metabolites unclear. Here, we speculated might protect mucosa by increasing regulating metabolites. This study was conducted evaluate lesions its underlying...
Abstract Background: Intra-operative cell salvage (IOCS) and leukocyte-depleted filter (LDF) are widely used effective in saving blood. However, the safety issue concerning reinfusion of IOCS-LDF processed blood to renal carcinoma (RCC) patients with inferior vena cava (IVC) thrombus were inconclusive for fear increased risk cancer metastases. This study intends analyze circulating tumor (CTC) eliminating effect 5 RCC-IVC patients. Methods: A novel strategy integrating negative enrichment by...
Abstract Background To compare the effectiveness of intraoperative cell salvage (IOCS) combined with a modified leucocyte depletion filter (MLDF) IOCS regular (RLDF) in eliminating tumour cells from blood during metastatic spine surgery (MSTS). Methods Patients known primary epithelial who underwent MSTS were recruited for this study. Blood samples collected 5 stages: patients’ vein before anaesthesia induction (S1), operative field manipulation (S2), and after processing (S3) IOCS+RLDF (S4)...