A5100767226- Microbial infections and disease research
- Tryptophan and brain disorders
- Bacteriophages and microbial interactions
- Aquaculture disease management and microbiota
- Neuroinflammation and Neurodegeneration Mechanisms
- Parasitic Infections and Diagnostics
- Plant Virus Research Studies
- Reproductive biology and impacts on aquatic species
- Circadian rhythm and melatonin
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Sirtuins and Resveratrol in Medicine
- Gut microbiota and health
- Natural product bioactivities and synthesis
- Mitochondrial Function and Pathology
- Aquaculture Nutrition and Growth
- Biological Activity of Diterpenoids and Biflavonoids
- Insect-Plant Interactions and Control
- Cancer-related molecular mechanisms research
- Dietary Effects on Health
- Alzheimer's disease research and treatments
- Medical Research and Treatments
- Adipose Tissue and Metabolism
- Bacterial biofilms and quorum sensing
- Cancer, Lipids, and Metabolism
Guangdong Academy of Medical Sciences
2021-2025
Southern Medical University
2017-2025
Guangdong Provincial People's Hospital
2021-2025
Army Medical University
2017-2025
Sichuan Agricultural University
2025
Rice Research Institute
2025
University of South China
2021-2024
First Affiliated Hospital of Henan University
2017-2024
Capital Medical University
2009-2024
Beijing YouAn Hospital
2024
Metabolic endotoxemia originating from dysbiotic gut microbiota has been identified as a primary mediator for triggering the chronic low-grade inflammation (CLGI) responsible development of obesity. Capsaicin (CAP) is major pungent bioactivator in chili peppers and potent anti-obesity functions, yet mechanisms linking this effect to remain obscure. Here we show that mice fed high-fat diet (HFD) supplemented with CAP exhibit lower levels metabolic CLGI associated body weight gain....
The antibacterial mechanism of the Cu‐containing materials has not been fully understood although such understanding is crucial for sustained clinical use as bone implants. aim this study to investigate molecular mechanisms by which Gram‐positive Staphylococcus aureus inactivated through Cu‐bearing titanium alloys (Ti6Al4V5Cu). Cu ions released from are found contribute lethal damage bacteria. They destroy permeability bacterial membranes, resulting in leakage reducing sugars and proteins...
Previous population studies in evaluating the beneficial effects of capsaicin (CAP) have yielded inconclusive results, and mechanisms responsible for possible benefit remain unclear.The objective was to assess effect dietary CAP on metabolic immune profiles its potential associations with gut microbial patterns healthy adults.In a 6-week controlled feeding trial, subjects were given weight maintenance diet sequentially contained 0, 5, 10 mg/d from chili powder.The study conducted 12 enrolled...
Background: Circular RNAs (circRNAs) are a class of non-coding that have been demonstrated to play important roles in tumorigenesis. However, how circRNAs regulate the progression hepatocellular cancer (HCC) remains unclear.Methods: In present study, circRNA microarray analyses were performed with HCC tissues identify differentially expressed. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis was conducted on cell lines and tissues, circ0097009 found be...
Microglia play a critical role in maintaining neural function. While microglial activity follows circadian rhythm, it is not clear how this intrinsic clock relates to their function, especially stimulated conditions such as the control of systemic energy homeostasis or memory formation. In study, we found that microglia-specific knock-down core gene, Bmal1, resulted increased phagocytosis mice subjected high-fat diet (HFD)-induced metabolic stress and likewise among engaged cognitive...
ABSTRACT Insulin resistance is a common metabolic disease, and its pathogenesis still unclear. The decrease of glucagon‐like peptide‐1 (GLP‐1) level mediated by the alteration gut microbiota may be pathogenesis. study was to investigate regulatory effect dihydromyricetin (DHM) on GLP‐1 insulin induced high‐fat diet (HFD), further explore possible molecular mechanism. Mice were fed an HFD establish model determine whether DHM had protective effect. could improve resistance. increased serum...
Scope Previous studies have linked dietary capsaicin (CAP) intake to improved glucose homeostasis and insulin sensitivity. However, the underlying mechanisms remain unclear. Methods results Type 2 diabetic db/db mice are fed a chow diet with or without CAP treatment for 8 weeks. administration markedly improves tolerance sensitivity through decreasing gluconeogenesis increasing glycogen synthesis in liver. Furthermore, inhibits increase abundance of genus Lactobacillus its bile salt...
Colorectal cancer (CRC) is a disease involving variety of genetic and environmental factors. Sirtuin-3 (Sirt3) expressed at low level in tissues CRC, but it unclear how Sirt3 modulates colonic tumorigenesis. In this study, we found that gut microbiota play central role the resistance to CRC tumor formation wild-type (WT) mice through APC (Adenomatous Polyposis Coli)-mutant mouse transfer via Wnt signaling. We also Sirt3-deficient were hypersusceptible inflammation development altered...
Microglia are brain immune cells responsible for surveillance. Microglial activation is, however, closely associated with neuroinflammation, neurodegeneration, and obesity. Therefore, it is critical that microglial response appropriately adapts to different stressors. The circadian clock controls the cellular process involves regulation of inflammation energy hemostasis. Here, we observed a significant variation in expression markers related inflammation, nutrient utilization, antioxidation...
Abstract In clinical practice, tumor recurrence and metastasis after orthopedic prosthesis implantation is an intensely troublesome matter. Therefore, to develop implant materials with antitumor property extremely necessary meaningful. Magnesium (Mg) alloys possess superb biocompatibility, mechanical biodegradability in applications. However, whether they had seldom been reported. recent years, it showed that zinc (Zn) not only promote the osteogenic activity but also exhibit good property....
Background: Immunological and inflammatory mechanisms play an important role in schizophrenia. The neutrophil-to-lymphocyte ratio (NLR) is a value obtained by dividing the absolute number of neutrophils lymphocyte count represents biomarker systemic response. There are studies investigating NLR association with psychopathology. However, relationship has been only studied small numbers patients schizophrenia, which leads to conflicting results makes meta-analytic data difficult interpret. aim...
Aim: To investigate the anti-diabetic activity of amentoflavone (AME) in diabetic mice, and to explore potential mechanisms. Methods: Diabetic mice induced by high fat diet streptozotocin were administered with for 8 weeks. Biochemical indexes tested evaluate its effect. Hepatic steatosis, histopathology change pancreas was evaluated. The glucose metabolic enzymes, expression Akt pAkt, transporter type 4 (GLUT4) immunoreactivity detected. Results: AME decreased level glucose, total...
Berberine (BBR), a natural alkaloid derived from Coptis, has anticancer activity. Some researchers have found that it could restrain epithelial-mesenchymal transition (EMT) of melanoma, neuroblastoma, and other tumor cells. However, is unclear whether BBR can reverse EMT in hepatocellular carcinoma (HCC) gastric (GC). In our study, inhibited the migration invasion HepG2, MGC803, SGC7901 cells dose-dependent manner. Transcription sequencing assays showed Vimentin, MMP, Smad3 were...
Alzheimer's disease (AD) is a pervasive age-related and highly heritable neurodegenerative disorder but has no effective therapy. The complex cellular microenvironment in the AD brain impedes our understanding of pathogenesis. Thus, comprehensive investigation cell type-specific responses crucial to provide precise molecular targets for therapeutic development.Here, we integrated analyzed 4,441 differentially expressed genes (DEGs) that were identified from 263,370 single-cells cortex...