A5069374998- Medicinal plant effects and applications
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Aldose Reductase and Taurine
- Biological Activity of Diterpenoids and Biflavonoids
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- Phytoestrogen effects and research
- Biochemical effects in animals
- Exercise and Physiological Responses
- Gut microbiota and health
- Natural product bioactivities and synthesis
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- Dietary Effects on Health
- Cancer, Hypoxia, and Metabolism
- Antioxidant Activity and Oxidative Stress
- Genomics, phytochemicals, and oxidative stress
- Prenatal Substance Exposure Effects
- Mitochondrial Function and Pathology
- Peroxisome Proliferator-Activated Receptors
- Retinoids in leukemia and cellular processes
- High Altitude and Hypoxia
- Epigenetics and DNA Methylation
Army Medical University
2016-2025
Children's Hospital of Capital Institute of Pediatrics
2025
Army Medical College
2019-2024
China National Center for Food Safety Risk Assessment
2022
Xinqiao Hospital
2010-2016
Instituto de Nutricion e Higiene de los Alimentos
2014
University of Salento
2014
Chongqing University of Technology
2011-2012
Chengdu Medical College
2009-2010
Military University
2010
ABSTRACT The gut microbiota is found to be strongly associated with atherosclerosis (AS). Resveratrol (RSV) a natural phytoalexin anti-AS effects; however, its mechanisms of action remain unclear. Therefore, we sought determine whether the effects RSV were related changes in microbiota. We that attenuated trimethylamine- N -oxide (TMAO)-induced AS ApoE −/− mice. Meanwhile, decreased TMAO levels by inhibiting commensal microbial trimethylamine (TMA) production via remodeling Moreover,...
Trimethylamine-N-oxide (TMAO) has recently been identified as a novel and independent risk factor for promoting atherosclerosis through inducing vascular inflammation. However, the exact mechanism is currently unclear. Studies have established central role of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in pathogenesis Here, we examined potential NLRP3 TMAO-induced inflammation vitro vivo underlying mechanisms.Experiments using...
Resveratrol, a natural polyphenolic compound, is abundantly found in plant foods and has been extensively studied for its anti-cancer properties. Given the important role of CSCs (Cancer Stem Cells) breast tumorigenesis progression, it worth investigating effects resveratrol on CSCs. The article an attempt to investigate Resveratrol significantly inhibits proliferation BCSCs (breast cancer stem-like cells) isolated from MCF-7 SUM159, decreased percentage population, consequently reduced size...
Inflammation participates centrally in all stages of atherosclerosis (AS), which begins with inflammatory changes the endothelium, characterized by expression adhesion molecules. Resveratrol (RSV) is a naturally occurring phytoalexin that can attenuate endothelial inflammation; however, exact mechanisms have not been thoroughly elucidated. Autophagy refers to normal process cell degradation proteins and organelles, protective against certain injuries. Thus, we intended determine role...
Metabolic endotoxemia originating from dysbiotic gut microbiota has been identified as a primary mediator for triggering the chronic low-grade inflammation (CLGI) responsible development of obesity. Capsaicin (CAP) is major pungent bioactivator in chili peppers and potent anti-obesity functions, yet mechanisms linking this effect to remain obscure. Here we show that mice fed high-fat diet (HFD) supplemented with CAP exhibit lower levels metabolic CLGI associated body weight gain....
It has been previously demonstrated that genistein exhibits anticancer activity against breast cancer. However, the precise mechanisms underlying effect of genistein, in particular epigenetic basis, remain unclear. In this study, we investigated whether could modulate DNA methylation status and expression cancer‐related genes cancer cells. We treated MCF‐7 MDA‐MB‐231 human cells with vitro. found decreased levels global methylation, methyltransferase (DNMT) DNMT1 . Yet, DNMT3A DNMT3B showed...
The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has increased worldwide. In recent years, fecal microbiota transplantation (FMT) become an important promising method for the treatment MASLD. However, mechanism remains unclear. animal model with C57BL/6 male mice induced by high-fat diet (HFD) 12 weeks been introduced. Fecal and indole-3-carbinol (I3C) was given oral gavage. Our study demonstrated that a 6-week healthy gut tended to ameliorate hepatic...
Anthocyanins widely present in human diet and have a variety of health effects. This study investigates the anticancer effects an anthocyanin-rich extract from black rice (AEBR) on breast cancer cells vitro vivo. AEBR reduced viability cell lines MCF-7 (ER+, HER2/neu−), MDA-MB-231 (ER−, MDA-MB-453 HER2/neu+) induced apoptosis via intrinsic pathway by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP), depolarizing mitochondrial membrane potential, releasing cytochrome...
Scope Resveratrol (RSV), a natural polyphenol, has been reported to attenuate nonalcoholic fatty liver disease (NAFLD); however, its underlying mechanism is unclear. Autophagy was recently identified as critical protective during NAFLD development. Therefore, we investigated the role of autophagy in beneficial effects RSV on hepatic steatosis. Methods and results Via Oil red O staining, triglyceride, β‐hydroxybutyrate detection, found that decreased palmitate‐induced lipid accumulation...
Aims: Our previous clinical trial indicated that the flavonoid dihydromyricetin (DHM) could improve hepatic steatosis in patients with nonalcoholic fatty liver disease (NAFLD), altough potential mechanisms of these effects remained elusive. Here, we investigated hepatoprotective role DHM on high-fat diet (HFD)-induced NAFLD. Results: supplementation effectively ameliorate development NAFLD by inhibiting lipid accumulation both HFD-fed wild-type mice and palmitic acid-induced hepatocytes. We...
The concept of sarcopenic obesity refers to low muscle mass coupled with high adiposity in older adults. Sarcopenic is a new medical challenge that imposes tremendous financial burdens on healthcare authorities worldwide. This study investigated the effects resveratrol high-fat diet-induced aged rats and palmitate acid-induced atrophy L6 myotubes explored underlying mechanisms.In vivo, prevented loss myofiber size decrease, improved grip strength abolished excessive fat accumulation. In...
Previous population studies in evaluating the beneficial effects of capsaicin (CAP) have yielded inconclusive results, and mechanisms responsible for possible benefit remain unclear.The objective was to assess effect dietary CAP on metabolic immune profiles its potential associations with gut microbial patterns healthy adults.In a 6-week controlled feeding trial, subjects were given weight maintenance diet sequentially contained 0, 5, 10 mg/d from chili powder.The study conducted 12 enrolled...
Ampelopsin (AMP), a major bioactive constituent of Ampelopsis grossedentata, exerts number biological effects. In this study, we investigated its anti-cancer activity in human breast cancer cell lines, and explored the underlying mechanism action. Our results showed that treatment with AMP dose-dependently inhibited viability induced apoptosis MCF-7 MDA-MB-231 cells without cytotoxicity normal epithelial MCF-10A. Meanwhile, dose- dependently triggered reactive oxygen species (ROS) generation...
Fish oil has been used effectively in the treatment of cardiovascular disease via triglyceride reduction and inflammation modulation. This study aimed to assess effects fish on patients with nonalcoholic fatty liver (NAFLD) associated hyperlipidemia. Eighty participants NAFLD hyperlipidemia were randomly assigned consume (n=40, 4 g/d) or corn capsules for 3 months a double-blind, randomized clinical trial. Blood levels lipids, glucose insulin, enzymes, kidney parameters cytokines at baseline...
Abstract Aim Imbalanced mitochondrial dynamics including suppressed fusion has been observed in diabetic hearts. However, it is still unknown whether promoter an effective protection to This study was designed explore the efficacy of on cardiomyopathy (DCM). Methods Male Sprague‐Dawley rats were injected with streptozotocin (STZ, 65 mg/kg/d) intraperitoneally induce diabetes. Seven weeks after vehicle or STZ injection, control treated a promoter‐M1 (2 for 6 weeks. Moreover, M1 administrated...
Abstract Background Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury (TBI). However, the heterogeneity, multifunctionality, and time-dependent modulation damage outcome mediated by neutrophils after TBI remain poorly understood. Methods Using combined single-cell transcriptomics, metabolomics, proteomics analysis from patients mouse model, we investigate novel neutrophil phenotype its associated effects on...