A5100433561- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Nutrition and Health in Aging
- Gastric Cancer Management and Outcomes
- Body Composition Measurement Techniques
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Renal and related cancers
- Breast Lesions and Carcinomas
- Nonlinear Differential Equations Analysis
- Radiopharmaceutical Chemistry and Applications
- Ubiquitin and proteasome pathways
- Renal cell carcinoma treatment
- HER2/EGFR in Cancer Research
- Differential Equations and Numerical Methods
- MRI in cancer diagnosis
- Cancer Diagnosis and Treatment
Nanchang University
2023-2025
Shanghai First People's Hospital
2019-2025
Shanghai Jiao Tong University
2018-2025
Shenyang Pharmaceutical University
2025
Huzhou University
2025
Shandong University
2023-2024
Fujian Medical University
2010-2024
Yili Friendship Hospital
2024
Yangzhou University
2024
Ministry of Agriculture and Rural Affairs
2024
Aims: Our previous clinical trial indicated that the flavonoid dihydromyricetin (DHM) could improve hepatic steatosis in patients with nonalcoholic fatty liver disease (NAFLD), altough potential mechanisms of these effects remained elusive. Here, we investigated hepatoprotective role DHM on high-fat diet (HFD)-induced NAFLD. Results: supplementation effectively ameliorate development NAFLD by inhibiting lipid accumulation both HFD-fed wild-type mice and palmitic acid-induced hepatocytes. We...
The Chinese 1992 staging system for nasopharyngeal carcinoma (NPC) was revised in 2008 and renamed as the system. seventh edition of American Joint Committee on Cancer (AJCC) manual also defined new rules classifying NPC 2010. purpose current study is to compare 2 terms patient distribution efficacy predicting prognosis.A total 816 patients with untreated nondisseminated who underwent magnetic resonance imaging scan nasopharynx neck were studied retrospectively. All scans reevaluated...
Until recently, there have been limited options for patients with bone metastatic castration-resistant prostate cancer (BmCRPC) following the failure of or development resistance to docetaxel (DTX), which is one frontline treatments.Sterol regulatory element-binding protein 1 (SREBP1) reported regulate abnormal lipid metabolism and promote progression metastasis (PCa).The siRNA interferes SREBP1 may provide an efficient treatment when combined DTX.Methods: In this study, lipoic acid (LA)...
Abstract Few studies have investigated the relationship between sarcopenia and mild to moderate renal decline. This study aimed investigate chronic kidney disease (CKD) sarcopenia. In total, 123 patients hospitalized with CKD 57 healthy volunteers who underwent physical examination during same period (control group) were analyzed. Body compositions measured by dual-energy X-ray absorptiometry, relative appendicular skeletal muscle index (RASMI) was calculated. Muscular strength evaluated...
Gut microbiota (GM) affects the progression and response to treatment in liver diseases. The GM composition is diverse associated with different etiologies of Notably, alterations are observed patients portal hypertension (PH) secondary cirrhosis, hepatitis B virus (HBV) infection being a major cause cirrhosis China. Thus, understanding role HBV infection-related PH essential.
Abstract Three kinds of coronaviruses are highly pathogenic to humans, and two them mainly infect humans through Angiotensin‐converting enzyme 2 （ACE2）receptors. Therefore, specifically blocking ACE2 binding at the interface with receptor‐binding domain is promising achieve both preventive therapeutic effects coronaviruses. Alternatively, drug‐targeted delivery based on receptors can further improve efficacy safety inhalation drugs. Here, these approaches innovatively combined by designing a...
Limertinib (ASK120067) is a newly developed third-generation EGFR tyrosine kinase inhibitor targeting both sensitizing and Thr790Met (T790M) mutations. This study aimed to evaluate the efficacy safety of limertinib in patients with locally advanced or metastatic T790M-mutated NSCLC.This single-arm, open-label, phase 2b conducted at 62 hospitals across People's Republic China. Patients NSCLC centrally confirmed T790M mutations tumor tissue blood plasma who progressed after first-...
Study Design. Subgroup analysis of a retrospective clinical and animal trial [Study different doses methylprednisolone on functional recovery spinal cord injury]. Objective. The aimed to investigate the efficacy low-dose regimens in promoting neural repair after SCI. Summary Background Data. Spinal injury (SCI) can result sensory, motor, autonomic nerve dysfunction, often leading disability or death. Methylprednisolone (MP) is preferred medication for treatment Low-dose regimen may be safer...
Abstract The androgen receptor (AR) pathway is critical for prostate cancer carcinogenesis and development; however, after 18‐24 months of AR blocking therapy, patients invariably progress to castration‐resistant (CRPC), which remains an urgent problem be solved. Therefore, finding key molecules that interact with as novel strategies treat even CRPC desperately needed. In the current study, we focused on regulation RNA‐binding proteins (RBPs) associated determined mRNA protein levels were...
The development of new drug therapies for Alzheimer's disease (AD) is an important research topic today, but the pathogenesis AD has not been thoroughly studied, and there are still several shortcomings in existing therapies. Therefore, this study aims to explore molecular mechanism lactoferrin treatments ulcerative colitis (UC) which susceptible AD, starting from principle "one drug, two diseases, same treatment." This used pathological staining specific indicators preliminarily evaluate...
The proliferation and death of granulosa cells (GCs) in poultry play a decisive role follicular fate egg production. fluid (FF) contains variety nutrients genetic substances to ensure the communication between cells. Exosomes, as new intercellular communication, could carry transport proteins, RNA, lipids react on GCs, which had been found FF various domestic animals. Whether exosomes similar is unclear. In this study, geese, with low production, were chosen, effect GCs was investigated....
The utilization of Cobalt (Co) has surged due to it is critical role in renewable energy technologies and other high-tech applications. Concurrently, the potential health risks associated with Co exposure have raised concerns. Previous studies, including our own, shown that can impair learn memory functions as an epigenetic hazard, even at low concentrations. In this study, we explore mechanisms Co-induced ferroptosis neurodegenerative damage both vivo vitro, focusing on regulation by...