A5100623325- Cancer, Hypoxia, and Metabolism
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Dialysis and Renal Disease Management
- Cancer-related Molecular Pathways
- Tissue Engineering and Regenerative Medicine
- Adipose Tissue and Metabolism
- Chronic Kidney Disease and Diabetes
- Adenosine and Purinergic Signaling
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Epigenetics and DNA Methylation
- Caveolin-1 and cellular processes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Angiogenesis and VEGF in Cancer
- Trace Elements in Health
- Immune cells in cancer
- Lymphatic System and Diseases
- Mechanisms of cancer metastasis
- Genetic and phenotypic traits in livestock
- Prenatal Substance Exposure Effects
- Mycorrhizal Fungi and Plant Interactions
- Liver Disease Diagnosis and Treatment
- Polysaccharides and Plant Cell Walls
- Drug Transport and Resistance Mechanisms
Wuhan No.1 Hospital
2012-2025
China Pharmaceutical University
2022-2025
Health Commission of Jilin Province
2025
Shandong Academy of Sciences
2022-2025
Shandong Food Fermentation Industry Research and Design Institute
2022-2025
Jilin University
2024
People's Hospital of Xinjiang Uygur Autonomous Region
2024
Henan University of Science and Technology
2024
Shandong University
2011-2024
Peking University Shenzhen Hospital
2020-2024
The molecular mechanisms underlying the regulation of pluripotency by cellular metabolism in human embryonic stem cells (hESCs) are not fully understood. We found that high levels glutamine essential to prevent degradation OCT4, a key transcription factor regulating hESC pluripotency. Glutamine withdrawal depletes endogenous antioxidant glutathione (GSH), which results oxidation OCT4 cysteine residues required for its DNA binding and enhanced degradation. emergence OCT4(lo) cell population...
Abstract Hypoxia is a crucial factor in tumor aggressiveness and resistance to therapy, especially glioblastoma. Our previous results have shown that melatonin exerts antimigratory anti‐invasive action glioblastoma cells under normoxia. However, the effect of on migration invasion hypoxic condition remains poorly understood. Here, we show strongly reduced hypoxia‐mediated U 251 87 cells. In addition, found significantly blocked HIF ‐1α protein expression suppressed downstream target genes,...
As the primary mediator for synaptic transmission, AMPA receptors (AMPARs) are crucial plasticity and higher brain functions. A downregulation of AMPAR expression has been indicated as one early pathological molecular alterations in Alzheimer’s disease (AD), presumably via amyloid-β (Aβ). However, mechanisms leading to loss AMPARs remain less clear. We report that neurons, application Aβ triggers internalization accompanied with a decrease cell-surface expression. Importantly, both...
Abstract Few studies have investigated the relationship between sarcopenia and mild to moderate renal decline. This study aimed investigate chronic kidney disease (CKD) sarcopenia. In total, 123 patients hospitalized with CKD 57 healthy volunteers who underwent physical examination during same period (control group) were analyzed. Body compositions measured by dual-energy X-ray absorptiometry, relative appendicular skeletal muscle index (RASMI) was calculated. Muscular strength evaluated...
Abstract Glioblastoma multiforme (GBM) remains incurable despite multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a narrow margin (2–3 cm) of the initial resected lesion due to unreachable residual cancerous cells. Here, completely biodegradable microneedle for cavity delivery glioblastoma‐associated macrophages (GAMs)‐activating immune nano‐stimulator that mitigates glioblastoma is reported. The tumor lesion‐directed biocompatible releases and...
Sustaining proliferative signaling is one of the hallmarks cancer. Granulocyte-colony stimulating factor (G-CSF), a hematopoietic growth that controls proliferation and differentiation neural stem cells, may contribute to development glioma. In present study, we evaluated expression G-CSF its receptor (G-CSFR) in various grades glioma samples primary cell culture derived from glioblastoma patient as well different human lines. We showed G-CSFR were widely expressed by samples, The levels not...
Lysocardiolipin acyltransferase (LYCAT), a cardiolipin-remodeling enzyme regulating the 18:2 linoleic acid pattern of mammalian mitochondrial cardiolipin, is necessary for maintaining normal function and vascular development. We hypothesized that modulation LYCAT expression in lung epithelium regulates development pulmonary fibrosis.To define role human murine models fibrosis.We analyzed correlation peripheral blood mononuclear cells (PBMCs) with outcomes functions overall survival, used to...
<title>Abstract</title> Nrf1 is a transcription factor that highly conserved and reacts to oxidative, proteotoxic endoplasmic reticulum stress in cells; nonetheless, its function the context of acute kidney injury (AKI) remains unclear. Using model cisplatin-induced nephrotoxicity vitro vivo, we found expression Nrf1, which expressed at high levels renal tubular cells, was significantly downregulated after cisplatin treatment. Proximal tubule-specific knockout worsened overexpression...
Background: The occurrence of urinary tract or kidney infection is correlated with intelligence, noncognitive education and cognition, but the causal relationship between them remains uncertain, which risk factors mediate this unknown. Methods: intelligence (n=269,867), (n=510,795) cognition data (n=257,700) were obtained from genome-wide association studies (GWAS) conducted in individuals European ethnicities. genetic associations these (UK Biobank, n=397,867) analyzed using linkage...
Cardiovascular disease (CVD) is the main cause of death in patients on chronic dialysis. The question whether dialysis modality impacts cardiovascular risk remains to be addressed. China Collaborative Study Dialysis, a multi-centers cohort study, was performed evaluate morbidity during maintenance hemodialysis (HD) and peritoneal (PD). consisted from database 9 largest facilities around China. inclusion period between January 1, 2005, December 2010. defined as presence clinically diagnosed...
Abstract The interaction of granulosa cells (GCs) with oocytes is important to regulate follicle development. exogenous melatonin promoting the maturation by GCs has been approved in pig, however, transcriptome profile and functions genes regulated have not yet be fully characterized. In this study, we found could stimulate synthesis estradiol pig GCs. RNA‐seq was used explore effects on gene expression, a total 89 differentially expressed (DEGs) were identified. Gene ontology analysis...
Abstract Dysfunction of neural stem cells (NSCs) has been linked to fetal neuropathy, one the most devastating complications gestational diabetes. Several studies have demonstrated that melatonin (Mel) exerted neuroprotective actions in various stresses. However, role autophagy and involvement Mel NSCs hyperglycemia (HG) not yet fully established. Here, we found HG increased autophagic flux as evidenced by increasing LC3B II/I ratio, Beclin-1 expression, autophagosomes. Moreover, enhanced...
Acidosis, regardless of hypoxia involvement, is recognized as a chronic and harsh tumor microenvironment (TME) that educates malignant cells to thrive metastasize. Although overwhelming evidence supports an acidic environment driver or ubiquitous hallmark cancer progression, the unrevealed core mechanisms underlying direct effect acidification on tumorigenesis have hindered discovery novel therapeutic targets clinical therapy. Here, chemical-induced transgenic mouse models for colon, liver...
Abstract The most common site of metastasis prostate cancer (PCa) is bone. Skeletal-related events can increase the risk death in patients with PCa by 28%. Due to low detection rate lesions prostate-specific antigen (PSA) levels, value 99m Tc methylene diphosphonate ( Tc-MDP) bone scintigraphy limited. Prostate-specific membrane (PSMA) a small molecular probe that efficiently and specifically detect lesions. This prospective study aimed evaluate difference between Tc-PSMA single-photon...
Recent studies have highlighted the importance of paracrine growth factors as mediators pro‐angiogenic effects by endothelial progenitor cells (EPCs), but little is known about release lipid‐based like endocannabinoids EPCs. In current study, anandamide and 2‐arachidonoylglycerol distinct human EPC sub‐types was measured using HPLC/tandem mass‐spectrometry. Anandamide highest adult blood colony‐forming EPCs at baseline they also demonstrated increased with TNF‐α stimulation. Treatment mature...
The metabolism that sustains cancer cells is adapted preferentially to glycolysis, even under aerobic conditions (Warburg effect). This effect was one of the first alterations in recognized as conferring a survival advantage. In this study, we show gene associated with retinoid-interferon-induced mortality-19 (GRIM-19), which previously identified tumor suppressor protein growth inhibition and cell apoptosis, contributes switch between oxidative glycolytic pathways. parallel this, vascular...
A novel technology to fabricate ECM sheet–implant complexes reducing immunogenicity and facilitating storage transportation.