A5100628730- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Meningioma and schwannoma management
- RNA modifications and cancer
- Head and Neck Surgical Oncology
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Pituitary Gland Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Nerve injury and regeneration
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Electrospun Nanofibers in Biomedical Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
Shandong University
2016-2025
Qilu Hospital of Shandong University
2016-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2021-2024
Edith Cowan University
2023-2024
Beijing Ditan Hospital
2024
Capital Medical University
2024
University of Bergen
2020-2023
Northwest A&F University
2023
South China Agricultural University
2023
Qingdao University
2022
Chronic subdural hematoma (CSDH) is a trauma-associated condition commonly found in elderly patients. Surgery currently the treatment of choice, but it carries significant risk recurrence and death. Nonsurgical treatments remain limited ineffective. Our recent studies suggest that atorvastatin reduces hematomas improves clinical outcomes patients with CSDH.To investigate safety therapeutic efficacy to nonsurgically treat CSDH.The Effect Atorvastatin on Subdural Hematoma (ATOCH) randomized,...
Abstract Dysregulated iron metabolism is a hallmark of many cancers, including glioblastoma (GBM). However, its role in tumor progression remains unclear. Herein, we identified coatomer protein complex subunit zeta 1 (COPZ1) as therapeutic target candidate which significantly dysregulated GBM cells. Overexpression COPZ1 was associated with increasing grade and poor prognosis glioma patients based on analysis expression data from the publicly available database The Cancer Genome Atlas ( P...
Abstract Astrocytes have important physiological roles in CNS homeostasis and serve as a bridge between the immune system. IL-17 IL-6 are many disorders characterized by neuroinflammation. We examined role of on signaling cascade primary astrocytes. functioned synergistic manner with to induce expression The effect involved numerous pathways including NF-κB, JNK MAPK, p38 MAPK. NF-κB pathway inhibitor BAY-11, JNKi II, SB203580 suppressed expression. synergized enhance recruitment activated...
Glioblastoma (GBM) is the most common and lethal type of malignant brain tumor in adults. Currently, interventions are lacking, median overall survival patients with GBM less than 15 months, postoperative recurrence rate greater 60%. We proposed an innovative local chemotherapy involving construction gene therapy-based iron oxide nanoparticles (IONPs) as a treatment for glioblastoma after surgery that targeted ferroptosis apoptosis to address these problems. The porous structure IONPs...
There is an urgent need for new therapeutic strategies patients with glioblastoma multiforme (GBM). Previous studies have shown that berberine (BBR), a natural plant alkaloid, has potent anti-tumor activity. However, the mechanisms leading to cancer cell death not been clearly elucidated. In this study, we show BBR profound effects on metabolic state of GBM cells, high autophagy flux and impaired glycolytic capacity. Functionally, these alterations reduce invasive properties, proliferative...
Flavokawain B (FKB), a natural kava chalcone, displays potent antitumor activity in various types of cancer. The mechanism action, however, remains unclear. Here, we evaluated the efficacy FKB treatment human glioblastoma multiforme (GBM) as well molecular basis for its inhibitory effects Approximately 60% GBM cells became senescent after with assessed senescence-associated (SA)-GLB1/SA-β-galactosidase assay. cellular process autophagy potentially contributed to establishment senescence....
Abstract Long non-coding RNAs play critical roles in tumour progression. Through analysis of publicly available genomic datasets, we found that MIR22HG, the host gene microRNAs miR-22-3p and miR-22-5p, is ranked among most dysregulated long glioblastoma. The main purpose this work was to determine impact MIR22HG on glioblastoma growth invasion elucidate its mechanistic function. MIR22HG/miR-22 axis highly expressed as well glioma stem-like cells compared normal neural stem cells. In...
Abstract NF-κB signaling plays a critical role in tumor growth and treatment resistance GBM as many other cancers. However, the molecular mechanisms underlying high, constitutive activity remains to be elucidated. Here, we screened panel of tripartite motif (TRIM) family proteins identified TRIM22 potential activator using an driven luciferase reporter construct cell lines. Knockout Cas9-sgRNAs led reduced proliferation, while overexpression enhanced proliferation populations, vitro...
Galangin (GG), a flavonoid, elicits potent antitumor activity in diverse cancers. Here, we evaluated the efficacy of GG treatment human glioblastoma multiforme (GBM) and investigated molecular basis for its inhibitory effects disease. inhibited viability proliferation GBM cells (U251, U87MG, A172) dose-dependent manner (IC50 = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 0.001), number colonies formed was significantly reduced (at 50 0.001). However, normal...
Recent evidence suggests that dysregulation of iron regulatory factors may play essential roles in cancer pathophysiology. Six-transmembrane epithelial antigen prostate 3 (STEAP3) is a metalloreductase, which vital for cellular uptake and homeostasis. However, the clinical significance function STEAP3 development human gliomas remain unclear. Through analysis publicly available databases, we found was highly expressed malignant gliomas, especially mesenchymal glioma molecular subtype...
Glioblastoma multiforme (GBM) is a common malignancy of the central nervous system, but conventional treatments yield unsatisfactory results. Although innovative therapeutic approaches have been developed, they prolong survival by only approximately 5 months. The heterogeneity GBM renders growth inhibition with single drug difficult, and exploring combination multiple targets for comprehensive treatment expected to overcome this limitation. In study, we designed biocompatible cRGD/Pt +...
Spinal cord injury (SCI) can lead to iron overloading and subsequent neuronal ferroptosis, which hinders the recovery of locomotor function. However, it is still unclear whether maintenance homeostasis enables revitalize intrinsic neurogenesis. Herein, we report regulation cellular after SCI via chelation excess ions modulation transportation pathway using polyphenol-based hydrogels for revitalization The reversed promote neural stem/progenitor cell differentiation into neurons elicit...
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by invasive behavior and compromised immune response, presenting treatment challenges. Surgical debulking of GBM fails to address its infiltrative nature, leaving neoplastic satellites in an environment impaired surveillance, ultimately paving the way for recurrence. Tracking eradicating residual cells boosting antitumor immunity critical preventing postoperative relapse, but effective immunotherapeutic strategies...
Abstract Accumulating evidence suggests that changes in the tumor microenvironment caused by radiotherapy are closely related to recurrence of glioma. However, mechanisms which such radiation‐induced involved regrowth have not yet been fully investigated. In present study, how cranial irradiation‐induced senescence non‐neoplastic brain cells contributes glioma progression is explored. It observed senescent facilitated enhancing peripheral recruitment myeloid inflammatory glioblastoma....
Establishing clinically relevant animal models of glioblastoma multiforme (GBM) remains a challenge, and many commonly used cell line-based do not recapitulate the invasive growth patterns patient GBMs. Previously, we have reported formation highly tumour xenografts in nude rats from human However, implementing based on primary tissue requires that these can be sufficiently standardised with consistently high take rates. In this work, collected data kinetics material 29 biopsies xenografted...
The importance of ectoenzymes CD39 and CD73 in mediating adenosinergic immunosuppression has been recognized, but their roles human malignant glioma–associated remain largely unknown. In this study, the ectoenzyme characteristics glioma cells infiltrating CD4+ T lymphocytes isolated from newly diagnosed patients were investigated. activities both cell populations determined by nucleotide hydrolysis assay. immunosuppressive property CD39-CD73 synergic effect was evaluated via responder T-cell...
Bone marrow mesenchymal stem cells (MSCs) transplantation has shown great promises for treating various central nervous system (CNS) diseases. However, poor viability of transplanted MSCs in injured CNS limited the therapeutic efficiency. Oxidative stress is one major mechanisms underlying pathogenesis diseases and a negative impact on survival MSCs. Melatonin recently been reported to have antioxidant anti-apoptotic properties serial cells. This study was designed investigate protective...
Article28 November 2019Open Access Transparent process Therapeutic implications of altered cholesterol homeostasis mediated by loss CYP46A1 in human glioblastoma Mingzhi Han Shandong Key Laboratory Brain Function Remodeling, Department Neurosurgery, Qilu Hospital University and Institute Brain-Inspired Science, University, Jinan, China Biomedicine, Bergen, Norway Search for more papers this author Shuai Wang orcid.org/0000-0002-0454-5281 Ning Yang Xu Wenbo Zhao Halala Sdik Saed Thomas Daubon...
Transgelin-2 (TAGLN2) is a member of the calponin family actin-bundling proteins that involved in regulation cell morphology, motility, and transformation. Here, clinical significance potential function TAGLN2 malignant gliomas were investigated. Molecular data was obtained from The Cancer Genome Atlas (TCGA) database. Gene ontology pathway analysis used to predict functions TAGLN2. RNA knockdown performed using siRNA or lentiviral contructs U87MG U251 glioma lines. Cells characterized vitro...
Long noncoding RNAs (lncRNA) have essential roles in diverse cellular processes, both normal and diseased cell types, thus emerged as potential therapeutic targets. A specific member of this family, the SWI/SNF complex antagonist associated with prostate cancer 1 (SChLAP1), has been shown to promote aggressive growth by antagonizing therefore serves a biomarker for poor prognosis. Here, we investigated whether SChLAP1 plays role development human glioblastoma (GBM).RNA-ISH IHC were performed...
Cancer cell migration and invasion are essential features of the metastatic process. Volatile anesthetic sevoflurane inhibits multiple cancer lines; however, its effects on glioma cells unclear. Emerging evidence suggests that microRNA (miRNA)-637 regulates through Akt1 pathway. Sevoflurane has been shown to modulate a number miRNAs. In present study, we examined whether and, if so, these beneficial mediated by miRNA-637. U251 were treated without (control) or with at low, moderate high...
Background: Splicing factors are essential for nascent pre-mRNA processing and critical in cancer progression, suggesting that proteins with splicing functions represent potential molecular targets therapy.Here, we investigate the role of glioblastoma multiforme (GBM) progression possibility targeting them treatment disease.Methods: The TCGA CGGA public databases were used to screen differentially expressed mRNA factors.Immunohistochemistry qRT-PCR analyze expression non-POU...