A5100444658- Hippo pathway signaling and YAP/TAZ
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Liver physiology and pathology
- Nanoplatforms for cancer theranostics
- Listeria monocytogenes in Food Safety
- Circular RNAs in diseases
- Neuroscience and Neural Engineering
- Cancer Genomics and Diagnostics
- Plant Molecular Biology Research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- MRI in cancer diagnosis
- Cognitive Radio Networks and Spectrum Sensing
- Single-cell and spatial transcriptomics
- Radiomics and Machine Learning in Medical Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Cells and Metastasis
Second Affiliated Hospital of Zhejiang University
2014-2025
Roswell Park Comprehensive Cancer Center
2014-2024
Cancer Genetics (United States)
2014-2024
Wenzhou Medical University
2024
Zhejiang University
2000-2023
Children's Hospital of Capital Institute of Pediatrics
2023
South China Agricultural University
2020-2023
University of Utah
2023
Chinese Institute for Brain Research
2019-2022
Zhejiang Lab
2019-2022
Epithelial-mesenchymal transition (EMT) is thought to contribute cancer metastasis, but its underlying mechanisms are not well understood. To define early steps in this cellular transformation, we analyzed human mammary epithelial cells with tightly regulated expression of Snail-1, a master regulator EMT. After Snail-1 induction, markers were repressed within 6 hr, and mesenchymal genes induced at 24 hr. binding target promoters was transient (6-48 hr) despite continued protein expression,...
Abstract Accumulating evidence suggests that changes in the tumor microenvironment caused by radiotherapy are closely related to recurrence of glioma. However, mechanisms which such radiation‐induced involved regrowth have not yet been fully investigated. In present study, how cranial irradiation‐induced senescence non‐neoplastic brain cells contributes glioma progression is explored. It observed senescent facilitated enhancing peripheral recruitment myeloid inflammatory glioblastoma....
Significance Genetic alterations are frequently observed in bladder cancer. In this study, we demonstrate that tumors can be classified into two different types based on the spectrum of genetic diversity they confer. one class tumors, tumor protein p53 mutations and a large number single-nucleotide structural variants. Another characteristic group was chromosome shattering, known as chromothripsis, mutational heterogeneity. The other did not show these profound aberrations, but found novel...
Brain disturbances, like injuries or aberrant protein deposits, evoke nucleotide release leakage from cells, leading to microglial chemotaxis and ingestion. Recent studies have identified P2Y12 purinergic receptors as triggers for P2Y6 mediators phagocytosis. However, pinocytosis, known the internalization of fluid-phase materials, has received much less attention. We found that ATP efficiently triggered pinocytosis in microglia. Pharmacological analysis knockdown experiments demonstrated...
In ultraviolet (UV) radiation-exposed skin, mutations fuel clonal cell growth. The relationship between UV exposure and the accumulation of (CMs) correlation CMs skin cancer risk are largely unexplored. We characterized 450 individual-matched sun-exposed (SE) non-SE (NE) normal human samples. number relative contribution were significantly different SE NE areas. Furthermore, we identified hotspots in
The success of glioma chemotherapy is hampered by low intratumoral drug concentration and severe toxicity in normal organs. Glioma diagnosis total tumor resection depend on enhanced magnetic resonance imaging (MRI) results which provide the best solution for recognizing mass anatomical details with high spatial resolution. Zeolite imidazole frameworks (ZIFs) have pore channel tunability, large specific surface area porosity, broad application prospects adsorption, catalysis loading. However,...
Abstract Members of the mammalian Vestigial-like (VGLL) family transcriptional cofactors activate genes in response to a wide variety environmental cues. Recently, VGLL proteins have been proposed regulate key signaling networks involved cancer development and progression. However, biological clinical significance dysregulation human breast pathogenesis remains unknown. Here, we report that diminished VGLL4 expression, but not VGLL1-3, correlated with both shorter relapse-free survival...
The neuromuscular junction (NMJ) is a synapse between motoneurons and skeletal muscles to control motor behavior. Unlike extensively investigated postsynaptic differentiation, less known about mechanisms of presynaptic assembly. Genetic evidence Wnt in mammalian NMJ development was missing due the existence multiple Wnts their receptors. We show when secretion abolished from by mutating ligand mediator (Wls) gene, mutant mice showed muscle weakness neurotransmission impairment. NMJs were...
Transitions in competence underlie the ability of CNS progenitors to generate a diversity neurons and glia. Retinal progenitor cells mouse early-born cell types embryonically late-born largely postnatally. We find that transition from early late is regulated by Jarid2. Loss Jarid2 results extended production expression genes. can regulate histone modifications, we reduction repressive mark H3K27me3 on subset genes with loss Jarid2, most notably Foxp1. show Foxp1 regulates retinal types,...
High-mobility group box 1 (HMGB1), originally described as a nuclear protein that binds to and modifies DNA, is now regarded central mediator of inflammation by acting cytokine. However, the association HMGB1 in peripheral blood with disease outcome cerebrovasospasm has not been examined patients aneurysmal subarachnoid hemorrhage. In this study, 303 consecutive were included. Upon admission, plasma levels measured ELISA. The end points mortality after year, in-hospital mortality, poor...
Long non-coding RNAs (lncRNAs) serve essential roles on various biological functions. Previous studies have indicated that lncRNAs are involved in the occurrence, growth and infiltration of brain tumors. LncRNA H19 is key regulator pathogenesis gliomas, but underlying mechanisms H19-regulated tumor progression remain unknown. Therefore, we investigated effects mechanism action lncRNA homeostasis glioma cells. As a novel oncogenic factor, up-regulation was able to promote proliferation cells...
Loss or dysfunction of tumor suppressor retinoblastoma (RB) is a common feature in various tumors, and contributes to cancer cell stemness drug resistance therapy. However, the strategy suppress eliminate Rb-deficient cells remains unclear. In present study, we accidentally found that reduction DNA replication licensing factor MCM7 induced more apoptosis RB-deficient than control cells. Moreover, after screening further studies, demonstrated statin Simvastatin Atorvastatin were able inhibit...
Internalins are surface proteins that utilized by Listeria monocytogenes to facilitate its invasion into human intestinal epithelial cells. The expression of a full-length InlA is one essential virulence factors for L. cross the barrier in order invade In this study, gene sequences inlA 120 isolates from food (n = 107) and humans 13) were analyzed. Premature stop codon (PMSC) mutations identified 51 (50 1 human). Six mutation types PMSCs identified. Among with inlA, there 44 serogroup 1/2c,...
The current histologically based grading system for glioma does not accurately predict which patients will have better outcomes or benefit from adjuvant chemotherapy. We proposed that combining the expression profiles of multiple long non-coding RNAs (lncRNAs) into a single model could improve prediction accuracy. included 1,094 three different datasets. Using least absolute shrinkage and selection operator (LASSO) Cox regression model, we built multiple-lncRNA-based classifier on basis...
Lower-grade glioma (LGG) is characterized by genetic and transcriptional heterogeneity, a dismal prognosis. Iron metabolism considered central for tumorigenesis, tumor progression microenvironment, although key iron metabolism-related genes are unclear. Here we developed validated an gene signature LGG RNA-sequence clinicopathological data from The Cancer Genome Atlas (TCGA) the Chinese Glioma (CGGA) were downloaded. Prognostic screened used to construct risk-score model via differential...
Salmonella Weltevreden is a pathogen associated with human diarrheal diseases found across the globe. However, knowledge of genomics and epidemiology this still limited.
Background and Objectives Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. The regulator G-protein signaling 5 (RGS5) has been reported to be highly expressed in some malignant tumors. However, its expression role HCC not reported. Methods RGS5 was examined liver cancer tissues cell lines by real-time quantitative PCR. migration invasion investigated wound healing transwell assay. epithelial–mesenchymal transition markers were detected Western...
Genetic and epigenetic alterations have been identified as to contribute directly or indirectly the generation of transitional cell carcinoma urinary bladder (TCC-UB).We previously found that amplification chromosome 6p22 is significantly associated with muscle-invasive rather than superficial TCC-UB.Here, we demonstrated Sox4, one candidate oncogenes located within amplicon, confers cancer stem (CSC) properties.Down-regulation Sox4 led inhibition migration, colony formation well...