A5049541644- Spinal Fractures and Fixation Techniques
- Terahertz technology and applications
- Spinal Hematomas and Complications
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Management of metastatic bone disease
- Cancer-related molecular mechanisms research
- Nerve injury and regeneration
- Cancer Cells and Metastasis
- Spine and Intervertebral Disc Pathology
- Spectroscopy Techniques in Biomedical and Chemical Research
- Sleep and Wakefulness Research
- Sleep and related disorders
- Photoacoustic and Ultrasonic Imaging
- Neurosurgical Procedures and Complications
- Hippo pathway signaling and YAP/TAZ
- Infrared Thermography in Medicine
- Bioactive natural compounds
- Genomics, phytochemicals, and oxidative stress
- Cancer Mechanisms and Therapy
- Nanoparticles: synthesis and applications
- Advanced Biosensing Techniques and Applications
- Advanced Chemical Sensor Technologies
- Biochemical and Structural Characterization
Southwest Hospital
2016-2024
Army Medical University
2016-2024
Qingdao University
2024
Capital Institute of Pediatrics
2023
Ningxia Medical University
2020-2023
Southwest General Health Center
2020
Chongqing University
2020
Background. Mammalian sterile 20-like kinase 1 (MST1), the key component of Hippo-YAP pathway, exhibits an important role in pathophysiological process various neurological disorders, including ischemic stroke and spinal cord injury. However, during subarachnoid hemorrhage, involvement MST1 pathophysiology early brain injury remains unknown. Methods. We employed intravascular filament perforation to establish hemorrhage (SAH) mouse model. The inhibitor XMU-MP-1 was intraperitoneally injected...
The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds bridge a sciatic injury and guide the growth of neurons; however, whether be used repair spinal cord injuries remains explored. In this study, conductive composited chitosan scaffold was fabricated by genipin crosslinking lyophilization. prepared chitosan-graphene presented porous structure an inner diameter 18–87 μm, reached 2.83...
Long non-coding RNAs (lncRNAs) serve essential roles on various biological functions. Previous studies have indicated that lncRNAs are involved in the occurrence, growth and infiltration of brain tumors. LncRNA H19 is key regulator pathogenesis gliomas, but underlying mechanisms H19-regulated tumor progression remain unknown. Therefore, we investigated effects mechanism action lncRNA homeostasis glioma cells. As a novel oncogenic factor, up-regulation was able to promote proliferation cells...
We demonstrated that different degrees of experimental traumatic brain injury (TBI) can be differentiated clearly in fresh slices rat tissues using transmission-type terahertz (THz) imaging system. The high absorption region THz images corresponded well with the injured area visible and magnetic resonance results. image characteristics dehydrated paraffin-embedded hematoxylin eosin (H&E)-stained microscopic were investigated to account for intrinsic differences suffered from TBI normal...
Cervical cancer (CC) is a common gynecological malignancy and represents major global health challenge. Chemotherapeutic agents are commonly applied in treatment of CC, while along various adverse effects chemotherapy resistance. As an iridoid glycoside compound, gentiopicroside (GPS) possesses the characteristic better availability lower toxicity effect on treatment. In present study, we investigated that GPS exhibited anticancer HeLa cells through inhibition cell growth, induced apoptosis,...
Abstract Curcumin (CUR) shows a remarkable antitumor activity against wide range of cancers such as glioma, but its underlying mechanism remains elusive. In this study, we aimed to explore the potential role H19/miR‐675/vitamin D receptor (VDR) in effect CUR glioma. Real‐time polymerase chain reaction and western‐blot analysis were used study or 1,25‐dihydroxyvitamin (1,25(OH) 2 3 ) on expression H19, miR‐675, VDR. addition, H19 VDR was also studied. Furthermore, between CUR‐loaded...
Abstract The morbidity, mortality, and disability associated with intraventricular hemorrhage (IVH) secondary to intracerebral (ICH) represent a global burden. To date, there is no effective therapy for ICH other than supportive care. In this study, we assessed the neuroprotective effects of Cattle encephalon glycoside ignotin (CEGI) injection in rat model ventricular extension (IVH/ICH). IVH/ICH was induced via type IV collagenase caudate nucleus Sprague-Dawley rats. experimental animals...
This “five-in-one” composite scaffold has been considered as a promising strategy to direct the axon growth, mimic properties of natural extracellular matrix and finally be used repair spinal cord injuries.
Demyelination is observed in animal models of intractable epilepsy (IE). Epileptogenesis damages the myelin sheath and dysregulates oligodendrocyte precursor cell (OPC) development. However, molecular pathways regulating demyelination are unclear. Here, we predicted mechanisms a rat model lithium-pilocarpine hydrochloride-induced epilepsy. We identified DGKA/Mboat2/Inpp5j NOS/Keratin 28 as main target molecules that regulate via glycerolipid glycerophospholipid metabolism,...
In recent years, the prevalence and mortality of autism spectrum disorder (ASD) have been increasing. The clinical features are different with cases, so treatment ways for each one.Baohewan Heshiwei Wen Dan Tang (BHWDT) has recommended treating autistic disorder. To investigate mechanism action how compounds interact ASD targets, network pharmacology molecular docking methods were used in this study.Traditional Chinese Medicine Systems Pharmacology (TCMSP) was to screen active components...
The diagnosis and treatment of glioma depends greatly on the rapid extraction molecular pathological features. In this study, human brain tumor tissues different grades were analyzed using terahertz (THz) attenuated total reflectance (ATR) time-domain spectroscopy. Substantial differences in THz parameters observed between paracarcinoma tissue grade I-IV gliomas, Furthermore, difference absorption coefficient increases with increase frequency. It was also demonstrated that isocitrate...
Introduction Fear and sleep impairments common co-exist, but the underlying mechanisms remain unclear. Hypothalamic orexinergic neurons are involved in regulation of sleep-wake fear expression. The ventrolateral preoptic area (VLPO) is an essential brain region to promote sleep, axonal fibers projecting VLPO maintenance sleep-wake. Neural pathways from hypothalamic orexin might mediate induced by conditioned fear. Methods To verify above hypothesis, electroencephalogram (EEG) electromyogram...
Progressive spinal deformity has become a well-recognized complication of intracanal tumors resection. However, the factors affecting post-operative stability remain to be further research. Here, we described current largest series risk analysis for progressive following resection tumors.We retrospectively analyzed medical records patients with between January 2009 and December 2018. All who underwent performed regular postoperative follow-up were identified included in study. Clinical,...
Hesperetin is an abundant flavonoid in citrus fruits, and be confirmed to possess a chemo-preventive effect on cancer. Migration invasion are the main causes of death cervical cancer patients, which epithelial-mesenchymal transition (EMT) can directly contribute malignant phenotypes tumor cells. The present study aims investigate inhibitory hesperetin EMT-mediated migration cells through transforming growth factor-β1 (TGF-β1)/Smads pathway. Cell viability, cell ability, morphology were...
In this study, gold nanorods (GNRs), uniformly coated with polydopamine (PDA), were developed as a multifunctional nanocarrier for targeted, pH, and near infrared (NIR) irradiation dual-stimuli triggered drug delivery. Doxorubicin (DOX), hydrophobic chemotherapeutic drug, was conveniently heavily loaded into the through π – stacking hydrogen bonding interactions. It further passivated by thiolated poly(ethylene glycol)-tumor homing peptides (NGR TAT) to improve its cancer tissue penetrating,...
Terahertz wave is an electromagnetic wave, whose wavelength located between microwave and infrared wavelength. Based on low ionization fingerprint characteristics, it has great potential applications in biomedical field, especially the intraoperative localization qualitative diagnosis of tumors. Glioma most urgent tumor for positioning diagnosis. Owing to its invasiveness heterogeneity, easy relapse after resection a significant influence nerve function adjacent brain regions. Therefore,...
Sleep disorders are common comorbidities in patients with temporal lobe epilepsy (TLE), but the underlying mechanisms remain poorly understood. Since lateral hypothalamic (LH) and perifornical orexinergic (ORX) melanin-concentrating hormone (MCH) neurons known to play opposing roles regulation of sleep arousal, dysregulation ORX MCH might contribute disturbance sleep-wakefulness following epileptic seizures.To test this hypothesis, rats were treated lithium chloride pilocarpine induce status...
Objective To investigate the neuroprotective effect of cattle encephalon glycoside and ignotin injection on rat model traumatic brain injury (TBI). Methods Three hundred six SD rats were randomly divided into sham group, TBI high dose middle group low according to random number table. Rats received 1.8, 0.6 0.2 ml/kg for 28 days in high, groups, respectively. was induced by modified Feeney's weight-drop method. Rat mortality, neurological function score learning memory ability...