A5005342407- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Barrier Structure and Function Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Terahertz technology and applications
- Advanced Malware Detection Techniques
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Network Security and Intrusion Detection
- Spinal Cord Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Spectroscopy and Laser Applications
- Cancer-related gene regulation
- Advanced Chemical Sensor Technologies
- Spinal Hematomas and Complications
- Signaling Pathways in Disease
- Nerve injury and regeneration
- Acute Ischemic Stroke Management
- Inflammasome and immune disorders
- Biochemical Acid Research Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Aldose Reductase and Taurine
- Blood properties and coagulation
- Spam and Phishing Detection
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
Army Medical University
2015-2022
Southwest Hospital
2015-2022
Chinese PLA General Hospital
2022
Chinese People's Liberation Army
2021
Shandong University
2011-2018
Second Hospital of Shandong University
2013-2015
Hangzhou Dianzi University
2009-2010
Emerging studies have demonstrated the important physiological and pathophysiological roles of hydrogen sulphide (H2S) as a gasotransmitter for NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome-associated neuroinflammation in central nervous system. However, effects H2S on after intracerebral haemorrhage (ICH), especially NLRP3 inflammasome, remain unknown. We employed Sprague–Dawley rat collagenase-induced ICH present study. The time course content spatial expression...
Blockading P2X7 receptor(P2X7R) provides neuroprotection toward various neurological disorders, including stroke, traumatic brain injury, and subarachnoid hemorrhage. However, whether how receptor suppression protects blood-brain barrier(BBB) after intracerebral hemorrhage(ICH) remains unexplored. In present study, intrastriatal autologous-blood injection was used to mimic ICH in rats. Selective P2X7R inhibitor A438079, agonist BzATP, siRNA were administrated evaluate the effects of...
The imaging diagnosis and prognostication of different degrees traumatic brain injury (TBI) is very important for early care clinical treatment. Especially, the exact recognition mild TBI bottleneck current label-free technologies in neurosurgery. Here, we report an automatic evaluation method with terahertz (THz) continuous-wave (CW) transmission based on machine learning (ML). We propose a new feature extraction biological THz images combined transmittance distribution features spatial...
Abstract Objective The potential roles and mechanisms of pericytes in maintaining blood–brain barrier (BBB) integrity, which would be helpful for the development therapeutic strategies subarachnoid hemorrhage (SAH), remain unclear. We sought to provide evidence on role BBB disruption possible involvement mechanism CypA signaling both cultured SAH models. Methods Three hundred fifty-three adult male C57B6J mice weighing 22 30 g, 29 −/− mice, +/+ (flox/flox) neonatal were used investigate time...
Background. Mammalian sterile 20-like kinase 1 (MST1), the key component of Hippo-YAP pathway, exhibits an important role in pathophysiological process various neurological disorders, including ischemic stroke and spinal cord injury. However, during subarachnoid hemorrhage, involvement MST1 pathophysiology early brain injury remains unknown. Methods. We employed intravascular filament perforation to establish hemorrhage (SAH) mouse model. The inhibitor XMU-MP-1 was intraperitoneally injected...
Blood-brain barrier (BBB) disruption and subsequent brain edema play important roles in the secondary neuronal death neurological dysfunction that are observed following intracerebral hemorrhage (ICH). In previous studies, transient receptor potential vanilloid 4 (TRPV4), a calcium-permeable mechanosensitive channel, was shown to induce cytotoxicity many types of cells role orchestrating functions. present study, we explored TRPV4 ICH-induced injury, specifically investigating its effect on...
Abstract SARS-CoV-2 can encode circular RNAs (circRNAs); however, the potential effects of exogenous circRNAs on cardiovascular sequelae remain unknown. Three derived from nucleocapsid (N) gene SARS-CoV-2, namely, circSARS-CV2-Ns, were identified for functional studies. In particular, circSARS-CV2-N1368 was shown to enhance platelet adhesiveness endothelial cells (ECs) and inhibit EC-dependent vascular relaxation. Moreover, expression suppressed EC proliferation migration decreased...
Malware is an increasingly important problem that threatens the security of computer systems. The new concept cloud require rapid and automated detection classification malicious software. In this paper,we propose a behavior-based method. Depends on behavioral analysis we characterize malware profile in trace report. This report contains status change caused by executable event which are transfered from corresponding Win32 API calls their certain parameters, extract behaviour unit strings as...
Many previous clinical studies have demonstrated that the nigrostriatal pathway, which plays a vital role in movement adjustment, is significantly impaired after stroke, according to medical imaging and autopsies. However, basic pathomorphological changes been poorly investigated date. This study was designed explore changes, mechanism, therapeutic method of impairment intracerebral hemorrhage (ICH).Intrastriatal injection autologous blood or microtubule depolymerization reagent nocodazole...
We demonstrated that different degrees of experimental traumatic brain injury (TBI) can be differentiated clearly in fresh slices rat tissues using transmission-type terahertz (THz) imaging system. The high absorption region THz images corresponded well with the injured area visible and magnetic resonance results. image characteristics dehydrated paraffin-embedded hematoxylin eosin (H&E)-stained microscopic were investigated to account for intrinsic differences suffered from TBI normal...
Background and Purpose— Accumulated evidence suggests that hemin—a breakdown product of hemoglobin—plays a pivotal role in the inflammatory injuries result after hemorrhagic stroke through Toll Like Receptor 2-Toll 4 signal pathway. However, mechanism how hemin triggers neuronal necroptosis directly intracranial hemorrhage (ICH) is still an area active research. As animal model preclinical studies have shown, recombinant interleukin-1 receptor antagonist (IL-1RA) improves clinical outcomes...
Piezo1 is a mechanically-gated calcium channel. Recent studies have shown that Piezo1, channel, can attenuate both psychosine- and lipopolysaccharide-induced demyelination. Because oligodendrocyte damage demyelination occur in intracerebral hemorrhage, this study, we investigated the role of hemorrhage. We established mouse model cerebral hemorrhage by injecting autologous blood into right basal ganglia found was largely expressed soon (within 48 hours) after primarily oligodendrocytes....
Abstract Insufficient remyelination due to impaired oligodendrocyte precursor cell (OPC) differentiation and maturation is strongly associated with irreversible white matter injury (WMI) neurological deficits. We analyzed whole transcriptome expression elucidate the potential role underlying mechanism of action lipocalin-2 (LCN2) in OPC WMI identified receptor SCL22A17 downstream transcription factor early growth response protein 1 (EGR1) as key signals contributing LCN2-mediated...
Abstract The morbidity, mortality, and disability associated with intraventricular hemorrhage (IVH) secondary to intracerebral (ICH) represent a global burden. To date, there is no effective therapy for ICH other than supportive care. In this study, we assessed the neuroprotective effects of Cattle encephalon glycoside ignotin (CEGI) injection in rat model ventricular extension (IVH/ICH). IVH/ICH was induced via type IV collagenase caudate nucleus Sprague-Dawley rats. experimental animals...
Progressive white matter (WM) impairments caused by subarachnoid hemorrhage (SAH) contribute to cognitive deficits and poor clinical prognoses; however, their pathogenetic mechanisms are poorly understood. We investigated the role of nexilin oligodendrocyte progenitor cell (OPC)-mediated repair in a mouse model experimental SAH generated via left endovascular perforation. Nexilin expression was enhanced elevated migration OPCs after SAH. Knocking down siRNA reduced OPC both vitro vivo...
Objective: Ankylosing spondylitis (AS) is an inflammatory disease of unknown origin. Both genetic and environmental factors are involved. A recent genome-wide association study (GWAS) found anthrax toxin receptor 2 (ANTXR2) to be associated with AS in Caucasians. We aimed investigate whether the ANTXR2 polymorphism also a Chinese Shandong Han population.Methods: From 2008 2009, we recruited 309 patients 384 age- sex-matched controls nationality. selected six single nucleotide polymorphisms...
Neural stem/progenitor cells (NSPCs) are a promising candidate for the cell-replacement therapy after central nervous system (CNS) injury. However, short of sufficient NSPCs migration and integration into lesions is an essential challenge cell-based CNS injury due to disturbance local environmental homeostasis. Chondroitin sulfate proteoglycan (CSPG) obviously accumulated at destroyed homeostasis The previous study has demonstrated that CSPG dominating ingredient inhibiting axonal regrowth...