A5065213671- Terahertz technology and applications
- Photonic and Optical Devices
- Spectroscopy and Laser Applications
- Solid State Laser Technologies
- Photorefractive and Nonlinear Optics
- Advanced Fiber Laser Technologies
- Superconducting and THz Device Technology
- Plasmonic and Surface Plasmon Research
- Advanced Fiber Optic Sensors
- Metamaterials and Metasurfaces Applications
- Crystallization and Solubility Studies
- Laser Design and Applications
- X-ray Diffraction in Crystallography
- Photonic Crystals and Applications
- Pregnancy and preeclampsia studies
- Alzheimer's disease research and treatments
- Acoustic Wave Resonator Technologies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced Chemical Sensor Technologies
- Photoacoustic and Ultrasonic Imaging
- Gyrotron and Vacuum Electronics Research
- Advanced Fluorescence Microscopy Techniques
- Semiconductor Lasers and Optical Devices
- Metabolomics and Mass Spectrometry Studies
- Birth, Development, and Health
China-Japan Friendship Hospital
2022-2025
Shenzhen University
2024-2025
Tianjin University
2014-2024
Northeast Agricultural University
2023-2024
University of North Carolina at Chapel Hill
2024
Huazhong Agricultural University
2021-2024
Southeast University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Dezhou University
2024
General Hospital of Shenyang Military Region
2019-2024
Several blood-based biomarkers are promising to be used in the diagnosis of Alzheimer's disease (AD) including Aβ42/40, p-tau181, and neurofilament light (NfL). The kidney is associated with clearance proteins. It crucial evaluate effect renal function on diagnostic performance these before clinical implementation, which important for establishment reference ranges interpretation results.This study a cross-sectional analysis based ADNI cohort. Renal was determined by estimated glomerular...
This paper reviews recent advances in the design and performance of our original InP- GaAs-based plasmonic high-electron-mobility transistors (HEMTs) for ultrahighly-sensitive terahertz (THz) sensing imaging. First, fundamental theory THz detection is briefly described. Second, single-gate HEMTs with parasitic antennae are introduced as a basic core device structure, their characteristics sub-THz imaging potentialities investigated. Third, dual-grating-gate (DGG)-HEMT structures investigated...
In this letter, a temperature sensor based on fiber ring laser with reflective Sagnac loop is proposed. The inserted into the through download optical used as filter and sensing head to supply high sensitivity. As varies, transmission spectrum of changes, leading shift emission wavelength laser. We obtain system sensitivity 1.739 nm/°C, narrow 3-dB bandwidth less than 0.05 nm, signal-to-noise ratio ~50 dB. Moreover, it convenient achieve remote by changing length fiber.
The imaging diagnosis and prognostication of different degrees traumatic brain injury (TBI) is very important for early care clinical treatment. Especially, the exact recognition mild TBI bottleneck current label-free technologies in neurosurgery. Here, we report an automatic evaluation method with terahertz (THz) continuous-wave (CW) transmission based on machine learning (ML). We propose a new feature extraction biological THz images combined transmittance distribution features spatial...
We demonstrated that in vivo brain glioma a mouse model using continuous-wave terahertz reflection imaging system, as well the ex fresh tissues model. The tumor regions of and can be distinguished by THz intensity at frequency 2.52THz. images with high sensitivity correlated magnetic resonance, visual hematoxylin eosin stained images. Furthermore, spectral difference between gliomas normal were obtained 0.6THz to 2.8THz range, where have higher refractive indices absorption coefficients,...
The diversity and practicability of terahertz metamaterials have experienced rapid development in the past decade due to increasing demand for various devices. This topic has attracted significant interest from researchers. Among key functional devices metamaterial systems, active control ability is highly valuable captivating. implies that electromagnetic properties can be modulated over a wide dynamic range by external stimuli. review categorizes different types tunable based on stimuli...
For developing a continuous-wave (CW) tunable Terahertz-wave (THz-wave) source using difference-frequency generation (DFG) in highly nonlinear optical crystals, we proposed and demonstrated dual-wavelength fiber ring laser system operating around 1060 nm based on wideband chirped Bragg gratings (CFBGs) semiconductor amplifier (SOA). Thermo-induced phase shift along the CFBG produces very sharp transmission spike therefore two lasing wavelengths with single longitudinal mode operation are...
Abstract Background Alzheimer’s disease is a prevalent with heavy global burden. Proteomics the systematic study of proteins and peptides to provide comprehensive descriptions. Aiming obtain more accurate convenient clinical diagnosis, researchers are working for better biomarkers. Urine which could reflect change at an earlier stage. Thus, we conducted cross-sectional investigate novel diagnostic panels. Methods We firstly enrolled participants from China-Japan Friendship Hospital April...
A humidity sensor based on Fabry-Perot interferometer (FPI) and intracavity sensing of a fiber ring laser is proposed experimentally demonstrated. compact humidity-sensitive fiber-optic FPI developed inserted in laser. Because the output power modulated by reflection loss at different ambient humidity, induced. The experiment shows that relative has good linear response to from 25%RH 95%RH sensitivity 0.202 dB/%RH obtained with narrow 3-dB bandwidth high signal-to-noise ratio. Furthermore,...
The early diagnosis of blast-induced traumatic brain injury (bTBI) is great clinical significance for prognostication and treatment. Here, we report a new strategy bTBI through serum cerebrospinal fluid (CSF) based on terahertz time-domain spectroscopy (THz-TDS). spectral differences CSF different degrees experimental in rats have been demonstrated the period. In addition, THz spectra total protein hypothalamus hippocampus were investigated at time points after blast exposure, which both...
Abstract Background Alzheimer’s disease, the most prevalent cause of dementia, is a worldwide health problem. Proteomics systematic study proteins and peptides to provide comprehensive descriptions. Aiming obtain more accurate convenient clinical diagnosis, researchers are working on blood biomarkers. Method This review synthesizes findings from previous studies investigating biomarkers for disease using proteomic approaches. Results We summarized application proteomics as diagnostic...
Abstract Optical tweezers have found extensive applications across the realms of biophysics and nanoscience due to its ability capture particles at both micro‐ nanoscales. Serving as nanoscale force sensors, optical are capable measuring physical properties nanoparticles with piconewton‐level precision, offering significantly higher accuracy compared other measurement techniques, particularly for biological samples. Given rapid advancements in tweezers, a comprehensive review their role is...
We demonstrated that different degrees of experimental traumatic brain injury (TBI) can be differentiated clearly in fresh slices rat tissues using transmission-type terahertz (THz) imaging system. The high absorption region THz images corresponded well with the injured area visible and magnetic resonance results. image characteristics dehydrated paraffin-embedded hematoxylin eosin (H&E)-stained microscopic were investigated to account for intrinsic differences suffered from TBI normal...
A compact efficient high-repetition-rate doubly-resonant dual-wavelength KTP optical parametric oscillator (OPO), with output power up to 3.65 W and tuning ranges of 2.088-2.133 μm/2.171-2.122 μm for signal/idler waves, was deployed terahertz (THz) generation in a GaSe crystal. Based on difference frequency (DFG), the THz wave continuously tunable from 730.9 (0.41 THz) 80.8 (3.71 THz), believed be first report widely-tunable source. The maximum average reached 1.2 μW at 1.54 corresponding...
A high-energy, tunable, long-wave mid-infrared optical parametric oscillator (OPO) based on the BaGa4Se7 crystal was demonstrated in this Letter with 1064 nm laser pumping. The OPO designed as a double-pass single resonant (DP-SRO) to reduce threshold and improve outputs. Further optimization cavity length theoretically experimentally studied. With short of 30 mm, output energy over 1 mJ/pulse at 11 µm obtained pump 39.5 mJ/pulse. In addition, wide tuning range 8-14 achieved by rotating crystal.