A5100669952- Cancer Cells and Metastasis
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Prostate Cancer Treatment and Research
- Cancer, Stress, Anesthesia, and Immune Response
- RNA Research and Splicing
- Neuropeptides and Animal Physiology
- Ubiquitin and proteasome pathways
- Biofuel production and bioconversion
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Microbial Metabolic Engineering and Bioproduction
- Extracellular vesicles in disease
- Protein Degradation and Inhibitors
- Cancer Mechanisms and Therapy
- RNA regulation and disease
- Lung Cancer Treatments and Mutations
- Molecular Biology Techniques and Applications
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
Army Medical University
2015-2025
Princess Margaret Cancer Centre
2016-2025
University Health Network
2015-2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2025
The People's Hospital of Guangxi Zhuang Autonomous Region
2024-2025
Guangxi Medical University
2015-2025
Hunan Agricultural University
2012-2025
Daping Hospital
2014-2024
Sun Yat-sen University
2009-2024
Beijing Tian Tan Hospital
2024
Abstract The invasion of malignant glioma cells into the surrounding normal brain tissues is crucial for causing poor outcome this tumor type. Recent studies suggest that stem-like (GSLCs) mediate invasion. However, it not clear whether microenvironment factors, such as tumor-associated microglia/macrophages (TAM/Ms), also play important roles in promoting GSLC In study, we found primary human gliomas and orthotopical transplanted syngeneic glioma, number TAM/Ms at invasive front was...
Neuroendocrine prostate cancer (NEPC), a lethal form of the disease, is characterized by loss androgen receptor (AR) signaling during neuroendocrine transdifferentiation, which results in resistance to AR-targeted therapy. Clinically, genomically and epigenetically, NEPC resembles other types poorly differentiated tumors (NETs). Through pan-NET analyses, we identified ONECUT2 as candidate master transcriptional regulator NETs. ectopic expression adenocarcinoma synergizes with hypoxia...
Abstract Rheumatoid arthritis (RA) is a common chronic inflammatory disorder that usually affects joints. It was found roburic acid (RBA), an ingredient from anti-RA herb Gentiana macrophylla Pall., displayed strong anti-inflammatory activity. However, its medical application limited by hydrophobicity, lack of targeting capability and unclear functional mechanism. Here, we constructed pH responsive dual-target drug delivery system hitchhiking RBA (RBA-NPs) targeted both CD44 folate...
It has been recently reported that a side population of cells in nasopharyngeal carcinoma (NPC) displayed characteristics stem-like cancer cells. However, the molecular mechanisms underlying modulation such cell populations NPC remain unclear. Epstein-Barr virus was first identified human tumor to be associated with various malignancies, most notably NPC. LMP2A, encoded latent protein, play roles oncogenic processes. We report by immunostaining our current study LMP2A is overexpressed 57.6%...
Medial artery calcification is a common macroangiopathy that initiates from cell-regulated process similar to osteogenesis. Although the mechanisms governing this remain unclear, epigenomic regulation by specific microRNAs might play role in vascular smooth muscle cell (VSMC) calcification. In study, we aimed investigate whether miR-204 participates of VSMC We found was suppressed mouse aortic VSMCs during β-glycerophosphate-induced calcification, whereas Runx2 protein levels were elevated....
Abstract The mechanism of local inflammation and systemic injury in chronic periodontitis is complicated, which exosomes play an important role. In our study, we found that T helper cell 17 (Th17)/regulatory (Treg) balance destabilized the peripheral blood patients with periodontitis, upregulated Th17 or downregulated Treg, respectively. Porphyromonas gingivalis lipopolysaccharide (LPS) was used to simulate inflammatory microenvironment periodontitis. were extracted from periodontal ligament...
Glycogen synthase kinase-3β (GSK-3β), a serine/threonine protein kinase, may function as tumor suppressor or an oncogene, depending on the type. We sought to determine biological of GSK-3β in osteosarcoma, rare pediatric cancer for which identification new therapeutic targets is urgent.We used cell viability assays, colony formation and apoptosis assays analyze effects altered expression U2OS, MG63, SAOS2, U2OS/MTX300, ZOS osteosarcoma lines. Nude mice (n = 5-8 per group) were injected with...
Abstract Background Cancer stem cell model suggested that tumor progression is driven by the overpopulation of cancer cells and eradicating or inhibiting symmetric division would become most important therapeutic strategy. However, clinical evidence for this hypothesis still scarce. To evaluate association percentage CD133 + with clinicopathological parameters in colon was investigated since a putative marker shared multiple solid tumors. Patients methods Tumor tissues matched adjacent...
Androgen receptor (AR) signaling is a key driver of prostate cancer, and androgen-deprivation therapy (ADT) standard treatment for patients with advanced metastatic disease. However, receiving ADT eventually develop incurable castration-resistant cancer (CRPC). Here, we report that the chromatin modifier LSD1, an important regulator AR transcriptional activity, undergoes epigenetic reprogramming in CRPC. LSD1 this setting activated subset cell-cycle genes, including CENPE, centromere binding...
Abstract Background Severe burns injury is a serious pathology, leading to teratogenicity and significant mortality, it also has long-term social impact. The aim of this article describe the hospitalized population with severe injuries in eight burn centers China between 2011 2015 suggest future preventive strategies. Methods This 5-year retrospective review included all patients database at institutions. data collected gender, age, month distribution, etiology, location, presence inhalation...
Abstract Background The outcome of patients with colon cancer is still unsatisfied nowadays. Simvastatin a type statins anti-cancer activity, but its effect on cells remains unclear. present study intended to determine the underlying mechanism simvastatin in treatment cancer. Methods viability and pyroptosis rate treated untreated were analysed by CCK-8 flow cytometry assays, respectively. We used DCFH-DA detect reactive oxygen species (ROS) production. Levels markers detected western...
Oct4 and Sox2 are two major transcription factors related to the stem cell self-renewal differentiation. The aim of this study was examine association between expression levels with both clinicopathological characteristics prognoses patients hypopharyngeal squamous carcinoma.Tumor tissue samples from 85 carcinoma were collected, clinical follow-up data these recorded, status examined in by immunohistochemistry (IHC).Oct4 found be an independent predictive factor for overall survival (p =...