A5003054022- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Circular RNAs in diseases
- CAR-T cell therapy research
- Melanoma and MAPK Pathways
- Wound Healing and Treatments
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Protist diversity and phylogeny
- Developmental Biology and Gene Regulation
- Virus-based gene therapy research
- Skin and Cellular Biology Research
- Protein Degradation and Inhibitors
- Preterm Birth and Chorioamnionitis
- Cancer, Lipids, and Metabolism
- Multiple Myeloma Research and Treatments
- RNA regulation and disease
- Herpesvirus Infections and Treatments
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- NF-κB Signaling Pathways
- Skin Protection and Aging
- Microtubule and mitosis dynamics
Moffitt Cancer Center
2015-2021
Beijing Institute of Big Data Research
2020
Princess Margaret Cancer Centre
2019
University Health Network
2019
The University of Texas MD Anderson Cancer Center
1990-2019
Amway (United States)
2016
Baylor College of Medicine
2016
Touro University California
2015
Brigham and Women's Hospital
2015
Angiochem (Canada)
2013
Neuroendocrine prostate cancer (NEPC), a lethal form of the disease, is characterized by loss androgen receptor (AR) signaling during neuroendocrine transdifferentiation, which results in resistance to AR-targeted therapy. Clinically, genomically and epigenetically, NEPC resembles other types poorly differentiated tumors (NETs). Through pan-NET analyses, we identified ONECUT2 as candidate master transcriptional regulator NETs. ectopic expression adenocarcinoma synergizes with hypoxia...
Abstract Cutaneous squamous cell carcinoma (cuSCC) comprises 15–20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets molecularly targeted chemoprevention, here we perform integrated cross-species genomic analysis development through preneoplastic AK stage using matched human samples and solar ultraviolet radiation-driven Hairless mouse model. We...
Early-onset squamous cell carcinoma in recessive dystrophic epidermolysis bullosa patients is characterized by APOBEC mutagenesis.
Importance Intravenous magnesium sulfate administered to pregnant individuals before birth at less than 30 weeks’ gestation reduces the risk of death and cerebral palsy in their children. The effects later gestational ages are unclear. Objective To determine whether administration 34 or 2 years. Design, Setting, Participants This randomized clinical trial enrolled expected deliver was conducted 24 Australian New Zealand hospitals between January 2012 April 2018. Intervention (4 g) compared...
Oncolytic viral (OV) therapy, which uses genetically engineered tumor-targeting viruses, is being increasingly used in cancer clinical trials due to the direct cytolytic effects of this treatment that appear provoke a robust immune response against tumor. As OVs enter tumor cells, intrinsic host defenses have potential hinder replication and spread within mass. In report, we show histone deacetylase 6 (HDAC6) cells appears alter trafficking post-entry from nucleus toward lysosomes. glioma...
Tyrosine is mainly degraded in the liver by a series of enzymatic reactions. Abnormal expression tyrosine catabolic enzyme aminotransferase (TAT) has been reported patients with hepatocellular carcinoma (HCC). Despite this, aberration metabolism not investigated cancer development. In this work, we conduct comprehensive cross-platform study to obtain foundation for discoveries potential therapeutics and preventative biomarkers HCC. We explore data from The Cancer Genome Atlas (TCGA), Gene...
Glioblastoma (GBM) is one of the most common, aggressive, and invasive human brain tumors. There are few reliable mechanism-based therapeutic approaches for GBM patients. The transcriptional repressor RE1 silencing factor (REST) regulates oncogenic properties a class stem-like cells (high-REST [HR]-GSCs) in humans. However, it has been unclear whether REST represses specific targets to regulate functions or all with overlapping GSCs. We used genome-wide, biochemical, mouse intracranial...
Overexpression and activation of c-Jun N-terminal kinases (JNKs) have been observed in multiple cancer cell lines tumor samples. Various JNK isoforms reported to promote lung liver cancer, as well keratinocyte transformation, suggesting an important role signaling promoting development. However, there are three isoforms, it is unclear how each individual isoform, especially the ubiquitously expressed JNK1 JNK2, functions melanoma. Our previous study found that C116S mutations both JNK2...
Expression of the Spec3 gene Strongylocentrotus purpuratus is associated with ectodermal ciliogenesis. An antiserum was raised against amino terminus deduced acid sequence and used for immunofluorescent staining. Cilia an apical structure at base stained cilium each cell intensely in gastrula later stage embryos. Microtubule-depolymerizing agents dispersed concentrated spot staining, suggesting a localization antigen to Golgi complex. Immunogold electron microscopy confirmed on cilia showed...
Tyrosine is mainly degraded in the liver by a series of enzymatic reactions. Abnormal expression tyrosine catabolic enzyme aminotransferase (TAT) has been reported patients with hepatocellular carcinoma (HCC). Despite this, aberration metabolism not investigated cancer development. In this work, we conduct comprehensive cross-platform study to obtain foundation for discoveries potential therapeutics and preventative biomarkers HCC. We explore data from The Cancer Genome Atlas (TCGA), Gene...
Abstract Cutaneous squamous cell carcinoma (cuSCC) is the second most common skin cancer and commonly arises in chronically UV-exposed or chronic wounds. Since UV exposure wounds are two prominent environmental factors that lead to cuSCC initiation, we undertook this study test whether more acute molecular responses wounding overlapped with signatures of cuSCC. We reasoned transcriptional between acutely skin, wounded tumors, might enable us identify important pathways contributing performed...
Abstract While monoclonal antibodies to receptor tyrosine kinases such as HER2 have been demonstrated reduce tumor size and increase survival, these agents achieve little no brain penetration, making them ineffective against metastatic tumors. The blood-brain barrier (BBB), which restricts entry of proteins mAbs into the brain, is comprised capillary endothelial cells with tight junctions efflux pumps. Brain nutrients, hormones, other required molecules accomplished by processes...
Abstract Metabolic reprogramming has been emerging as a hallmark of cancer. Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, with about 700,000 new cases annually in U.S. We aim to investigate role miR-130b metabolism driver cSCC development. Since cancers have highest mutational loads among any human cancers, we used well-controlled comparisons across tissues and species narrow down number important candidate drivers. Using approach matched isogenic samples...
SHetA2 (NSC 726189), a “Flexible Heteroarotinoid” compound that is presently in preclinical development for cancer prevention through the National Cancer Institute (NCI) Rapid Access to Intervention Development (RAID) program has shown exert its anti‐cancer activity by regulating apoptosis, cell growth, differentiation and angiogenesis. However, may not be an ideal drug candidate due following two limitations: high lipophilicity (Log P=7.9) cumbersome six step synthesis. We have tried...
Abstract Cutaneous squamous cell carcinoma (cuSCC) is the second most common skin cancer, for which long term UV exposure and chronic wounding are dominant risk factors. Despite these clinically established connections, little understood about early molecular response of human to its connection acute cuSCC. Thus, our goal find specific signatures driven by UV-exposure as a means developing new approaches treating preventing Here, we perform integrated analyses proteomic, RNA-seq miR-seq on 3...