A5100342753- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
- Neurosurgical Procedures and Complications
- Reproductive Biology and Fertility
- Neurological Disease Mechanisms and Treatments
- Barrier Structure and Function Studies
- Cerebrospinal fluid and hydrocephalus
- S100 Proteins and Annexins
- Heme Oxygenase-1 and Carbon Monoxide
- Vascular Malformations Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Axon Guidance and Neuronal Signaling
- Diabetic Foot Ulcer Assessment and Management
- Ovarian function and disorders
- Autophagy in Disease and Therapy
- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- Neuroscience of respiration and sleep
- Nitric Oxide and Endothelin Effects
- Hydrogen's biological and therapeutic effects
Loma Linda University
2016-2025
New Hope Fertility Center
2015-2025
South China Agricultural University
2024-2025
East China University of Science and Technology
2024-2025
Fudan University
2013-2024
Anhui Provincial Hospital
2021-2024
Loma Linda University Medical Center
2014-2024
New York University
2000-2024
University Health System
2024
National University Health System
2024
Before licensure of varicella vaccine in 1995, was a universal childhood disease the United States, causing 4 million cases, 11,000 hospitalizations, and 100 deaths every year.To examine population-based surveillance data 3 communities to document impact vaccination program.Active for conducted among populations Antelope Valley, Calif; Travis County, Tex; West Philadelphia, Pa; from January 1, December 31, 2000. Reporting sites included child care centers, schools, universities, physicians,...
XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that essential for liver growth. Mice lacking displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target...
Myocardial infarction rapidly depletes the endogenous cardiac progenitor cell pool, and inefficient recruitment of exogenously administered cells limits effectiveness therapy. Recent reports indicate that interactions between CXC chemokine stromal cell–derived factor 1 its receptor 4 (CXCR4) critically mediate ischemia-induced bone marrow–derived circulating stem/progenitor cells, but expression CXCR4 in is very low. Here, we studied influence hypoxia on intravenously to ischemic heart...
Cold Atmospheric Plasma is an ionized gas that has recently been extensively studied by researchers as a possible therapy in dentistry and oncology. Several different gases can be used to produce such Helium, Argon, Nitrogen, Heliox, air. There are many methods of production which cold atmospheric plasma created. Each unique method biomedical areas. In dentistry, have mostly investigated the antimicrobial effects produced means remove dental biofilms eradicate oral pathogens. It shown...
Focal adjustment and zooming are universal features of cameras advanced optical systems. Such tuning is usually performed longitudinally along the axis by mechanical or electrical control focal length. However, recent advent ultrathin planar lenses based on metasurfaces (metalenses), which opens door to future drastic miniaturization mobile devices such as cell phones wearable displays, mandates fundamentally different forms lateral motion rather than longitudinal motion. Theory shows that...
Circular RNAs (circRNAs) are highly expressed in the CNS and regulate physiological pathophysiological processes. However, potential role of circRNAs stroke remains largely unknown. Here, we show that circRNA DLGAP4 (circDLGAP4) functions as an endogenous microRNA-143 (miR-143) sponge to inhibit miR-143 activity, resulting inhibition homologous E6-AP C-terminal domain E3 ubiquitin protein ligase 1 expression. circDLGAP4 levels were significantly decreased plasma acute ischemic patients (13...
Circular RNAs (circRNAs) are highly expressed in the central nervous system and involved regulation of physiological pathophysiological processes. However, potential role circRNAs stroke remains largely unknown. Here, using a circRNA microarray, we showed that circular RNA Hectd1 (circHectd1) levels were significantly increased ischemic brain tissues transient middle cerebral artery occlusion (tMCAO) mouse models further validated this finding plasma samples from acute (AIS) patients....
The introduction of universal varicella vaccination in 1995 has substantially reduced varicella-related morbidity and mortality the United States. However, it remains unclear whether vaccine-induced immunity wanes over time, a condition that may result increased susceptibility later life, when risk serious complications be greater than childhood.
Abstract As whole-genome sequencing for cancer genome analysis becomes a clinical tool, full understanding of the variables affecting output is required. Here using tumour-normal sample pairs from two different types cancer, chronic lymphocytic leukaemia and medulloblastoma, we conduct benchmarking exercise within context International Cancer Genome Consortium. We compare methods, pipelines validation methods. show that PCR-free methods increasing depth to ∼100 × shows benefits, as long...
Background: Stroke is a leading cause of adult disability that can severely compromise the quality life patients, yet no effective medication currently exists to accelerate rehabilitation. A variety circular RNA (circRNA) molecules are known function in ischemic brain injury. Lentivirus-based expression systems have been widely used basic studies circRNAs, but safety issues with such delivery limited exploration potential therapeutic roles for circRNAs. Methods: Circular SCMH1 (circSCMH1)...
Stroke continues to be a serious and significant health problem in the USA worldwide. This article will emphasize need for good laboratory practices, transparent scientific reporting, use of translational research models representative disease state develop effective treatments. allow testing development new innovative strategies so that efficacious therapies can developed treat ischemic hemorrhagic stroke. recommends guidelines research, most importantly, study blinding, group...
The NLRP3 (NALP3, cryopyrin) inflammasome, a key component of the innate immune system, facilitates caspase-1 and interleukin (IL)-1β processing, which amplifies inflammatory response. Here, we investigated whether knockdown decreases neutrophil infiltration, reduces brain edema, improves neurological function in an intracerebral hemorrhage (ICH) mouse model. We also determined mitochondrial reactive oxygen species (ROS) governed by permeability transition pores (mPTPs) would trigger...