A5033262856- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- Bayesian Methods and Mixture Models
- Statistical Methods and Bayesian Inference
- Optimal Experimental Design Methods
- Statistical Methods and Inference
- Advanced MRI Techniques and Applications
- AI in cancer detection
- Corneal Surgery and Treatments
- Reliability and Agreement in Measurement
- Hemodynamic Monitoring and Therapy
- Advanced Statistical Process Monitoring
- Statistical Distribution Estimation and Applications
- Gene expression and cancer classification
- Pharmaceutical Economics and Policy
- Clinical Laboratory Practices and Quality Control
- Machine Learning and Algorithms
- Medical Coding and Health Information
- HER2/EGFR in Cancer Research
- Meta-analysis and systematic reviews
- EEG and Brain-Computer Interfaces
- ECG Monitoring and Analysis
- Stochastic processes and statistical mechanics
- Sepsis Diagnosis and Treatment
- Transcranial Magnetic Stimulation Studies
Penn State Milton S. Hershey Medical Center
2025
DGA Partners
2019-2025
University of Pittsburgh
2019-2024
University of Manchester
2023
Walden University
2018-2019
United States Food and Drug Administration
1999-2016
Center for Devices and Radiological Health
2001-2016
University Hospital Schleswig-Holstein
2014
University of Lübeck
2014
Canadian Armed Forces
2010
The clinical performance of a laboratory test can be described in terms diagnostic accuracy, or the ability to correctly classify subjects into clinically relevant subgroups. Diagnostic accuracy refers quality information provided by classification device and should distinguished from usefulness, actual practical value, information. Receiver-operating characteristic (ROC) plots provide pure index demonstrating limits test's discriminate between alternative states health over complete...
Brain regions activated with complex sequential finger movements were localized by measuring regional cerebral blood flow (rCBF) positron emission tomography. Whereas the total number and frequency of kept constant, complexity auditory cued right hand varied, sequence length as independent variable. In four conditions differing complexity, bilateral primary sensorimotor area, left ventral premotor cortex, posterior supplementary motor superior part cerebellum, putamen consistently equally...
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To study the effect of repetition rate a simple movement on distribution and magnitude neuronal recruitment, we measured regional CBF (rCBF) in eight normal volunteers, using positron emission tomography 15O-labeled water. An auditory-cued, repetitive flexion right index finger against thumb was performed at very slow (0.25 0.5 Hz), (0.75 1 fast (2 2.5 (3 4 Hz) rates. The increase rCBF during relative to resting condition calculated for each pair conditions. Left primary sensorimotor cortex...
To evaluate the effect of repetition rate a simple movement on magnitude neuronal recruitment in primary sensorimotor cortex, we used blood flow-sensitive, echo planar functional magnetic resonance imaging (fMRI) sequence six normal volunteers. Three volunteers also had [ 15 O]water positron emission tomography (PET) studies using same paradigm. Previous PET shown an increase regional CBF (rCBF) with frequencies up to 2 Hz and then plateau cerebral flow at faster frequencies. extent...
Cholesterol accumulation in the Golgi of normal and Niemann-Pick Type C (NFC) fibroblasts was shown by freezefracture electron microscopy using filipin as a probe for unesterified cholesterol.The specific distribution cholesterol within individual compartments could be examined because membrane forms complexes with that are visible deformations (pits protuberances) freeze-fracture replicas.The density filipin-cholesterol deformations, quantitated cis, medial, tram cisternae vacuoles, to...
Journal Article Nonparametric bivariate estimation with randomly censored data Get access GREGORY CAMPBELL Purdue University, Department of StatisticsWest Lafayette, Indiana Search for other works by this author on: Oxford Academic Google Scholar Biometrika, Volume 68, Issue 2, August 1981, Pages 417–422, https://doi.org/10.1093/biomet/68.2.417 Published: 01 1981 history Received: February 1980 Revision received: November
Parvovirus is the most common viral cause of diarrhea in young puppies. Based on analysis a partial VP2 sequence 54 samples, canine parvovirus type 2c (CPV-2c) (n = 26), CPV-2b 25), and CPV-2 3) were detected United States. The American isolates have unique codons (494 572) VP2.
The loss of heterozygosity (LOH) at specific regions the human genome in tumor DNA is recognized as evidence for a tumor-suppressor gene located within corresponding region homologous chromosome. Restriction fragment length polymorphism analysis panel primary breast DNAs has led to identification two additional on chromosomes 17q and 18q that frequently are affected by LOH. Deletions each these have significant correlation with clinical parameters associated aggressive carcinomas. Previous...
Proton magnetic resonance spectroscopy (1H-MRS) is evolving from single-volume localized acquisitions to multiple-volume using spectroscopic imaging (1H-MRSI). The normal regional patterns of 1H-MRSI-detectable metabolite signal intensities have yet be established. We studied 13 healthy young adults with a multiple-section 1H-MRSI technique. signals measured were N-acetylaspartate (NA), choline-containing compounds (CHO), creatine-phosphocreatine (CRE), and lactate. Ten neuroanatomic regions...
Abstract A new environmental enrichment device, termed a “foraging/grooming board,” was presented to 8 individually housed rhesus monkeys for the explicit purpose of reducing level aberrant behaviors manifested by these animals. The consisting piece plexiglass covered with artificial fleece, had particles food treats rubbed into it and attached outside each animal's home cage. All animals foraged from board point that significant reduction in abnormal behavior noted. Most also groomed fleece...
SUMMARY objective We wished to determine whether there was size heterogeneity of the parathyroid glands in patients with familial multiple endocrine neoplasia type 1 (FMEN1) and primary hyperparathyroldlsm design At National Institutes Health we performed a retrospective analysis gland volume either from initial or repeat exploration studied subjects FMEN1 hyperparathyroldfsm measurements The estimated recorded orthogonal diameters. Volume could also be conservatively many for which one more...
Abstract Nonparametric multiple comparisons are discussed, with particular emphasis given to stepwise procedures. analogs of the all-subset procedure Einot and Gabriel presented, along an ad hoc nonparametric analog Newman—Keuls procedure. These new procedures compared among themselves nonstepwise based on Type I error levels comparisonwise power. It is shown that these control levels, they have superior pairwise power commonly used