A5100365258- Immune cells in cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Multiple Sclerosis Research Studies
- Immune Response and Inflammation
- Extracellular vesicles in disease
- Sirtuins and Resveratrol in Medicine
- interferon and immune responses
- Genomics, phytochemicals, and oxidative stress
- Peripheral Neuropathies and Disorders
- Natural product bioactivities and synthesis
- Congenital Heart Disease Studies
- Cell Adhesion Molecules Research
- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Systemic Lupus Erythematosus Research
- Ginseng Biological Effects and Applications
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Neurological Disease Mechanisms and Treatments
Hebei Medical University
2015-2025
Second Hospital of Hebei Medical University
2015-2025
Yangzhou University
2025
Shanghai Jiao Tong University
2017-2025
Ministry of Agriculture and Rural Affairs
2025
South China Agricultural University
2022-2025
Key Laboratory of Guangdong Province
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Shandong Marine Resource and Environment Research Institute
2024
Qingdao University
2014-2024
Background: Stroke is a leading cause of adult disability that can severely compromise the quality life patients, yet no effective medication currently exists to accelerate rehabilitation. A variety circular RNA (circRNA) molecules are known function in ischemic brain injury. Lentivirus-based expression systems have been widely used basic studies circRNAs, but safety issues with such delivery limited exploration potential therapeutic roles for circRNAs. Methods: Circular SCMH1 (circSCMH1)...
Macrophages are versatile immune cells that can detect a variety of pathogen-associated molecular patterns through their Toll-like receptors (TLRs). In response to microbial challenge, the TLR-stimulated macrophage undergoes an activation program controlled by dynamically inducible transcriptional regulatory network. Mapping complex mammalian network poses significant challenges and requires integration multiple experimental data types. this work, we inferred underlying murine activation....
Resveratrol (trans-3,4',5-trihydroxystilbene), a natural polyphenolic compound detected in grapes, berries, and peanuts, possesses wide spectrum of pharmacological properties, including anti-tumor metastasis activities. However, the underlying mechanisms through which resveratrol inhibits pancreatic cancer are still not fully elucidated. As epithelial-to-mesenchymal transition (EMT) is key player for tumor, aim this study to determine whether affects EMT cells related mechanism. The results...
Radiotherapy to cancer patients is inevitably accompanied by normal tissue injury, and the bone one of most commonly damaged tissues. Damage marrow mesenchymal stem cells (BM-MSCs) induced radiation thought be a major cause radiation-induced loss. Exosomes exhibit great therapeutic potential in treatment osteoporosis, but whether exosomes are involved loss has not been thoroughly elucidated date. The main purpose this study investigate role derived from BM-MSCs restoring recipient BM-MSC...
Stimulator of IFN genes (STING) is a central adaptor protein that mediates the innate immune responses to DNA virus infection. Although ubiquitination essential for STING function, how ubiquitination/deubiquitination system regulated by infection control activity remains unknown. In this study, we found USP21 an important deubiquitinating enzyme and it negatively regulates virus–induced production type I interferons hydrolyzing K27/63-linked polyubiquitin chain on STING. HSV-1 recruited at...
Shikonin, a botanical drug extracted from Lithospermum erythrorhizon, exhibits anti-cancer effects in various cancer cell lines. However, the mechanisms underlying these have not been completely elucidated yet. Here, we showed that Shikonin induces apoptosis and autophagy A375 cells inhibits their proliferation. caused G2/M phase arrest through upregulation of p21 downregulation cyclin B1. significantly triggered ER stress-mediated by upregulating expression p-eIF2α, CHOP, cleaved caspase-3....
Ginkgo biloba L., an ancient dioecious gymnosperm, is now cultivated worldwide for landscaping and medical purposes. A novel biflavonoid-amentoflavone 7''-O-β-D-glucopyranoside (1)-and four known biflavonoids were isolated identified from the male flowers of Ginkgo. The anti-proliferative activities five evaluated on different cancer lines. Bilobetin (3) isoginkgetin (4) exhibited better Their effects found to be cell-specific in a dose time dependent manner most sensitive HeLa cells....
Specifically targeting glioblastoma multiforme (GBM) blood vessels and actively enhancing the permeability of brain-blood-tumor barrier (BBTB) are two extremely difficult challenges currently hindering development effective therapies against GBM. Herein, a liposome drug delivery system (S1P/JS-K/Lipo) is described, which delivers nitric oxide (NO) prodrug JS-K, O2 -(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl) piperazin-1-yl] diazen-1-ium-1,2-diolate, to GBM tumors using sphingosine-1-phosphate...
Multiple sclerosis (MS) still maintains increasing prevalence and poor prognosis, while glucagon-like peptide-1 receptor (GLP-1R) agonists show excellent neuroprotective capacities recently. Thus, we aim to evaluate whether the GLP-1R agonist liraglutide (Lira) could ameliorate central nervous system demyelination inflammation.The therapeutic effect of Lira was tested on experimental autoimmune encephalitis (EAE) in vivo a microglia cell line BV2 vitro.Lira administration disease score EAE...
Abstract To conquer the worldwide outbreak of COVID-19 virus, a large number studies have been carried out on infection, transmission and treatment. However, few conducted from perspectives circRNA lncRNA, which are known to be involved in regulating many life activities, such as immune tolerance escapes, hence may provide invaluable information emerging infection recurrence. Moreover, exosomes has reported play an important role recurrence, thus interact with expression lncRNA. In this...
Osteoarthritis (OA) is the most common degenerative joint disease in world. Gene therapy based on delivering microRNAs (miRNAs) into cells has potential for treatment of OA. However, effects miRNAs are limited by poor cellular uptake and stability. Here, we first identify a type microRNA-224-5p (miR-224-5p) from clinical samples patients with OA that can protect articular cartilage degeneration further synthesize urchin-like ceria nanoparticles (NPs) load miR-224-5p enhanced gene Compared...
Human infections with the H7N9 influenza virus have been eliminated in China through vaccination of poultry; however, has not yet eradicated from poultry. Carefully analysis viruses poultry that sub-optimal immunity may provide a unique opportunity to witness evolution highly pathogenic avian context vaccination. Between January 2020 and June 2023, we isolated 16 samples collected during surveillance were sent us for disease diagnosis. Genetic indicated these belonged single genotype...
Abstract Gefitinib (Gef) provides clinical benefits to non-small cell lung cancer (NSCLC) patients with activating EGFR mutations. However, acquired resistance (AR) is a major obstacle effective Gef therapy. This study demonstrated that resveratrol (Res) could synergize inhibit the proliferation of Gef-resistant NSCLC cells. The underlying mechanisms synergism were investigated and results showed cotreatment Res phosphorylation by increasing intracellular accumulation through impairment...
The p53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis, resulting in higher intracellular NADPH, lower reactive oxygen species (ROS) autophagy activity. In this study, we investigated whether TIGAR might exert dual impacts on cancer cell survival based its ability to inhibit both autophagy. liver or lung cells treated with the anticancer drug epirubicin, levels increased a dose- time-dependent manner. silencing enhanced epirubicin-induced elevations ROS rates, manner...
// Bin Li 1,2,3 , Jin 1,7 Wen Xu 1,3 Xin Yuan Guan 2,4 Yan Ru Qin 5 Yi Zhang 4 Simon Law 2,6 Sai Wah Tsao 1,2 and Annie L.M. Cheung 1 Department of Anatomy, Ka Shing Faculty Medicine, The University Hong Kong, Pokfulam, Kong SAR, China 2 Centre for Cancer Research, 3 Kong-Shenzhen Institute Research Innovation (HKU-SIRI), Clinical Oncology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, 6 Surgery, 7 Present Address: Center Molecular Medicine Austrian Academy Sciences, Vienna,...