A5110957995- Selenium in Biological Systems
- Heavy Metal Exposure and Toxicity
- Multisensory perception and integration
- Microbial Metabolic Engineering and Bioproduction
- Mercury impact and mitigation studies
- Enzyme Catalysis and Immobilization
- Olfactory and Sensory Function Studies
- Color perception and design
- Clostridium difficile and Clostridium perfringens research
- Calcium signaling and nucleotide metabolism
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Genomics, phytochemicals, and oxidative stress
- Oral microbiology and periodontitis research
- Gastrointestinal motility and disorders
- Sexual Differentiation and Disorders
- Salivary Gland Disorders and Functions
- Cardiac Imaging and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
- Vascular Procedures and Complications
- Neonatal Respiratory Health Research
- Thyroid Disorders and Treatments
Shanghai Jiao Tong University
2007-2025
Shanghai Ninth People's Hospital
2025
National Clinical Research Center for Digestive Diseases
2025
Shandong Academy of Sciences
2024
XinHua Hospital
2012-2024
Qilu University of Technology
2024
Institute of Microbiology
2023
Chinese Academy of Sciences
2007-2023
Microbiology Institute of Shaanxi
2023
Hebei Medical University
2013-2019
Abstract Background Impaired osteo-/angiogenesis, excessive inflammation, and imbalance of the osteoimmune homeostasis are involved in pathogenesis alveolar bone defect caused by periodontitis. Unfortunately, there is still a lack ideal therapeutic strategies for periodontitis that can regenerate while remodeling microenvironment. Quercetin, as monomeric flavonoid, has multiple pharmacological activities, such pro-regenerative, anti-inflammatory, immunomodulatory effects. Despite its vast...
Accumulating evidence has shown that altered microRNA (miR) modulation is implicated in the pathologies of ischemic stroke. However, it unclear whether and how hsa-miR-19a-3p mediates cerebral injury. Herein, we investigated functional role miR-19a-3p injury explored its underlying regulatory mechanism.In vivo ischemic/reperfusion (I/R) neuronal vitro oxygen-glucose deprivation (OGD) were established. Expression was determined by quantitative real-time polymerase chain reaction (qRT-PCR)....
Microglia activation is associated with the development of hypoxic-ischemic brain injury (HIBI). Neuroinflammation suppression might be a suitable therapeutic target in hypoxic oligodendrocyte injury. This study aims to determine whether clemastine can improve hypomyelination by suppressing activated microglia and promoting maturation progenitor cells (OPCs) HIBI.A bilateral common carotid artery occlusion (BCCAO) rat model that received continuous intraperitoneal injection (1 mg/kg) for 14...
BACKGROUND Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, characterized by cognitive impairment, altered consciousness, and psychiatric symptoms, including anxiety depression. These symptoms often exacerbate the overall prognosis quality life affected patients. However, underlying metabolic proteomic features associated with SAE-induced remain poorly understood. AIM To investigate clinical manifestations depression in patients sepsis SAE to explore their...
Postcardiac arrest syndrome yields poor neurological outcomes, but the mechanisms underlying this condition remain poorly understood. Autophagy plays an important role in neuronal apoptosis induced by ischemia. However, whether autophagy is involved neuron cardiac has been less studied. This study found that TRPML1 participates cerebral ischemic reperfusion injury. Primary neurons were isolated and treated with mucolipin synthetic agonist 1 (ML-SA1), as well infected recombinant lentivirus...
Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) are most often caused by bacterial pneumonia characterized severe dyspnea high mortality. Knowledge about the effects of current clinical strains is lacking. The aim this study was to investigate ability representative pathogenic bacteria isolated from patients cause ALI/ARDS in mice identify major virulence factor.Seven species were sputum unilaterally instilled into mouse airway. A histology performed determine effect....
Abstract Ferulic acid (FA) and p -coumaric ( -CA) are hydroxycinnamic inhibitors that mainly produced during the pretreatment of lignocellulose. To date, inhibitory mechanism compounds on Saccharomyces cerevisiae has not been fully elucidated. In this study, liquid chromatography-mass spectrometry (LC–MS) scanning electron microscopy (SEM) were used to investigate changes in S. cells treated with FA -CA. experiment, control group was denoted as CK, FA-treated F, -CA-treated P. One hundred...
Diabetic nephropathy (DN) stands as a pervasive chronic renal disease worldwide, emerging the leading cause of failure in end-stage disease. Our objective is to pinpoint potential immune biomarkers and evaluate causal effects prospective therapeutic targets context DN.
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection (LRTI) in infants worldwide. Nirsevimab, an extended half-life monoclonal antibody against RSV, approved China for prevention RSV disease infants; however, global nirsevimab trials did not enroll Chinese infants. To inform investigation LRTI infants, this Phase I, randomized, placebo-controlled trial evaluated pharmacokinetics (PK) and safety healthy adults. Participants were randomized 3:1 to a...
Audiovisual interaction has been one of the most important topics in cognitive neurosciences. Visual stimuli could significantly impact auditory perception, and vice versa. Nevertheless, how much change visual would influence perception remains to be investigated. In this paper, we designed an audiovisual experiment which subjects were required judge whether there is a intensities two sounds with 150 ms interval, while are simultaneously presented size-changed stimuli. Behavioral results...
Abstract Background Clostridium difficile infection (CDI) is common in patients with inflammatory bowel disease (IBD) and has been reported as a risk factor for poor outcome. However, gut microbiome mycobiome of IBD CDI have barely investigated. This study aimed to assess the CDI. Methods We collected fecal samples from concomitant (IBD-CDI group, n=38), no (IBD-only n=91), healthy subjects (HC, n=40). Patients characteristics including demographic data, severity, medication history were...
Excessive waste-activated sludge (WAS) and insufficient carbon source (CS) for biological nitrogen removal (BNR) often coexist in municipal sewage treatment. Although the volatile fatty acids (VFAs) bio-converted from is regarded as a high-bioavailability alternative CS, development limited by low VFAs production efficiency dewatering deterioration of sludge. We disengaged EPS low-temperature thermal-hydrolysis (LTH) high-speed hydro-cyclone (HSHC) pretreatment recovered it efficient...
<h3>Objective</h3> To investigate the effects of cholesterol-lowering therapy with rosuvastatin calcium tablet on coronary flow reserve (CFR) patients unstable angina pectoris (UAP) and hypercholesterolaemia. <h3>Method</h3> 40 UAP were randomly divided into therapeutic group (n=20) conventional (n=20). By using colour Doppler ultrasound was measured in before after 3 rnonths therapy. <h3>Result</h3> After for months serum total cholesterol (TC), low density lipoprotein (LDL-C), triglyceride...